Chemical and pharmacological investigation of the stem bark of Synadenium grantii

Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several sc...

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Bibliographic Details
Published in:	Planta medica Vol. 80; no. 6; p. 458
Main Authors:	Munhoz, Antonio C M, Minozzo, Bruno R, Cruz, Luiza S, Oliveira, Thaís L, Machado, Willian M, Pereira, Airton V, Fernandes, Daniel, Manente, Francine A, Vellosa, José C R, Nepel, Angelita, Barison, Andersson, Beltrame, Flávio L
Format:	Journal Article
Language:	English
Published:	Germany 01-04-2014
Subjects:	Administration, Oral Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants - isolation & purification Antioxidants - pharmacology Antioxidants - therapeutic use Benzothiazoles - metabolism Biphenyl Compounds - metabolism Carrageenan Edema - chemically induced Edema - drug therapy Euphorbia - chemistry Female Flavonoids - analysis Flavonoids - pharmacology Flavonoids - therapeutic use Humans Inflammation - chemically induced Inflammation - drug therapy Lanosterol - analogs & derivatives Lanosterol - isolation & purification Lanosterol - pharmacology Lanosterol - therapeutic use Peroxidase - metabolism Phytotherapy Picrates - metabolism Plant Bark - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Stems - chemistry Rats, Wistar Sulfonic Acids - metabolism Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenes - therapeutic use
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Summary:	Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, such as 2,2'-azino-bis (3-ethylenebenzothiazoline-6-sulfonic acid)• +, 1-diphenyl-2-picrylhydrazyl•, O2 • - , and HOCl, as well as an enzymatic system with human myeloperoxidase and an ex vivo hemolysis system. Furthermore, the oral administration of the crude bark extract was able to reduce carrageenan-induced rat paw edema as effectively as ibuprofen. These biological activities may be associated with the presence of flavonoids and terpenes, as revealed by HPLC and NMR analyses of the crude stem bark extract. The phytochemical investigations in this study resulted in the isolation of friedelin and 3β-friedelinol for the first time, while euphol and lanosterol were also isolated.
ISSN:	1439-0221
DOI:	10.1055/s-0034-1368300