Search Results - "Machado, Thayná R."

Toxicological assessment of SGLT2 inhibitors metabolites using in silico approach by JESUS, JÉSSICA B. DE, CONCEIÇÃO, RAISSA A. DA, MACHADO, THAYNÁ R., BARBOSA, MARIA L.C., DOMINGOS, THAISA F.S., CABRAL, LUCIO M., RODRIGUES, CARLOS R., ABRAHIM-VIEIRA, BÁRBARA, SOUZA, ALESSANDRA M.T. DE

“…Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are the latest class of drugs approved to treat type 2 DM (T2DM). Although adverse effects are…”
Get full text

4-oxoquinoline-3-carboxamide acyclonucleoside phosphonates hybrids: Human MCF-7 breast cancer cell death induction by oxidative stress-promoting and in silico ADMET studies by Machado, Thayná R., Faro, Letícia V., Mello, Angélica L.do Nascimento, Silva, David de O., Abrahim-Vieira, Bárbara de A., Rodrigues, Carlos R., Silva, Rita Hemanuelle S., Junior, Claudio S.Viana, Sola-Penna, Mauro, Boechat, Fernanda da C.S., de Souza, Marcos C., Zancan, Patricia, de Souza, Maria Cecília B.V., de Souza, Alessandra M.T.

“…•Compounds 15a-k were synthesized as antitumoral agents.•15c, 15e, 15g, and 15k showed significant cytotoxicity.•15c, g, and k increased the levels of reactive…”
Get full text

The p38 MAPK Inhibitors and Their Role in Inflammatory Diseases by Machado, Thamires R., Machado, Thayná R., Pascutti, Pedro G.

“…The p38 family is a highly evolutionarily conserved group of mitogen‐activated protein kinases (MAPKs) that is involved in and helps co‐ordinate cellular…”
Get full text