Impact of Metabolic Risk Factors on COVID-19 Clinical Outcomes: An Extensive Review

Impact of Metabolic Risk Factors on COVID-19 Clinical Outcomes: An Extensive Review

Background: Cardiovascular (CV) risk factors, particularly cardiometabolic, seem to be associated with heightened severity and increased morbimortality in patients infected with the novel Coronavirus disease-2019 (COVID-19). Methods: A thorough scoping review was conducted to elucidate and summarize...

Full description

Saved in:
Bibliographic Details
Published in:Current cardiology reviews Vol. 18; no. 6; pp. 11 - e090522204452
Main Authors: Azevedo, Rafael B, Wandermurem, Débora C R, Libório, Flávia C F, Machado, Maíra K, Ushijima, Natália M, Narde, Ramon S, D Pecly, Inah Maria, Muxfeldt, Elizabeth S
Format: Journal Article
Language:English
Published: United Arab Emirates Bentham Science Publishers Ltd 01-11-2022
Benham Science Publishers
Subjects:
Adipose tissue
Cardiovascular diseases
Clinical outcomes
Comorbidity
Coronaviruses
COVID-19
Diabetes mellitus
Dyslipidemia
Glucose tolerance
Health risks
Hyperactivity
Immunological tolerance
Inflammation
Insulin
Insulin resistance
Metabolism
Morbidity
Patients
Prognosis
Respiratory diseases
Risk analysis
Risk factors
Severe acute respiratory syndrome coronavirus 2
Viral diseases
COVID-19
Obesity
Dyslipidemias
Metabolic Syndrome
Sleep Apnea
Type 2
Heart Disease Risk Factors
Review
Diabetes Mellitus
Obstructive
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Cardiovascular (CV) risk factors, particularly cardiometabolic, seem to be associated with heightened severity and increased morbimortality in patients infected with the novel Coronavirus disease-2019 (COVID-19). Methods: A thorough scoping review was conducted to elucidate and summarize the latest evidence for the effects of adverse cardiac metabolic profiles on the severity, morbidity, and prognosis of COVID-19 infection. Results: The pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is complex, being characterized by viral-induced immune dysregulation and hypercytokinemia, particularly in patients with critical disease, evolving with profound endothelial dysfunction, systemic inflammation, and prothrombotic state. Moreover, cardiovascular comorbidities such as diabetes are the most prevalent amongst individuals requiring hospitalization, raising concerns towards the clinical evolution and prognosis of these patients. The chronic proinflammatory state observed in patients with cardiovascular risk factors may contribute to the immune dysregulation mediated by SARS-CoV-2, favoring more adverse clinical outcomes and increased severity. Cardiometabolism is defined as a combination of interrelated risk factors and metabolic dysfunctions such as dyslipidemia, insulin resistance, impaired glucose tolerance, and central adiposity, which increase the likelihood of vascular events, being imperative to specifically analyze its clinical association with COVID-19 outcomes. Conclusion: DM and obesity appears to be important risk factors for severe COVID-19. The chronic proinflammatory state observed in patients with excess visceral adipose tissue (VAT) possibly augments COVID-19 immune hyperactivity leading to more adverse clinical outcomes in these patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1573-403X
1875-6557
DOI:10.2174/1573403X18666220509154236