Topical Application of Cinnamaldehyde Promotes Faster Healing of Skin Wounds Infected with Pseudomonas aeruginosa

Topical Application of Cinnamaldehyde Promotes Faster Healing of Skin Wounds Infected with Pseudomonas aeruginosa

Wound healing can be delayed following colonization and infection with the common bacterium . While multiple therapies are used for their treatment, these are ineffective, expensive, and labour-intensive. Thus, there is an enormous unmet need for the treatment of infected wounds. Cinnamaldehyde, the...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 24; no. 8; p. 1627
Main Authors: Ferro, Thiago A F, Souza, Eliene B, Suarez, Mariela A M, Rodrigues, João F S, Pereira, Domingos M S, Mendes, Saulo J F, Gonzaga, Laoane F, Machado, Márcia C A M, Bomfim, Maria R Q, Calixto, João B, Arbiser, Jack L, Monteiro-Neto, Valério, André, Eunice, Fernandes, Elizabeth S
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 25-04-2019
MDPI
Subjects:
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial infections
Biofilms
Cinnamaldehyde
Cinnamon
Colonization
Debridement
Genotype & phenotype
Gram-positive bacteria
Growth factors
Infections
Inflammation
Interleukin 17
Metabolic rate
Metabolism
Nitric oxide
Pathogens
Pseudomonas aeruginosa
Skin
skin wound
Topical application
Transient receptor potential proteins
Vascular endothelial growth factor
Virulence
Wound healing
Pseudomonas aeruginosa
wound healing
cinnamaldehyde
skin wound
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Summary:Wound healing can be delayed following colonization and infection with the common bacterium . While multiple therapies are used for their treatment, these are ineffective, expensive, and labour-intensive. Thus, there is an enormous unmet need for the treatment of infected wounds. Cinnamaldehyde, the major component of cinnamon oil, is well known for its antimicrobial properties. Herein, we investigated the effects of sub-inhibitory concentrations of cinnamaldehyde in the virulence of . We also assessed its healing potential in -infected mouse skin wounds and the mechanisms involved in this response. Sub-inhibitory concentrations of cinnamaldehyde reduced metabolic rate and its ability to form biofilm and to cause haemolysis. Daily topical application of cinnamaldehyde on -infected skin wounds reduced tissue bacterial load and promoted faster healing. Lower interleukin-17 (IL-17), vascular endothelial growth factor (VEGF) and nitric oxide levels were detected in cinnamaldehyde-treated wound samples. Blockage of transient receptor potential ankyrin 1, the pharmacological target of cinnamaldehyde, abrogated its healing activity and partially reversed the inhibitory actions of this compound on VEGF and IL-17 generation. We suggest that topical application of sub-inhibitory concentrations of cinnamaldehyde may represent an interesting approach to improve the healing of -infected skin wounds.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24081627