Action of sisal (Agave sisalana, Perrine) extract in the in vitro development of sheep and goat gastrointestinal nematodes

[Display omitted] ► We evaluate Agave sisalana extract on sheep and goats nematodes. ► The results show a dose-dependent relationship. ► The best LC50 and LC95 occur in the LDT with 0.041 and 0.067mg/mL, respectively. ► The development and feeding inhibition on L1 are both 100% at a dose of 0.12mg/m...

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Bibliographic Details
Published in:	Experimental parasitology Vol. 131; no. 2; pp. 162 - 168
Main Authors:	Silveira, Roberta X., Chagas, Ana Carolina S., Botura, Mariana B., Batatinha, Maria J.M., Katiki, Luciana M., Carvalho, Camila O., Bevilaqua, Cláudia M.L., Branco, Alexsandro, Machado, Elane A.A., Borges, Simone L., Almeida, Maria A.O.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2012
Subjects:	Agavaceae Agave - chemistry Albendazole - pharmacology Albendazole - therapeutic use Animals Anthelmintics - pharmacology Anthelmintics - therapeutic use Dose-Response Relationship, Drug Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - parasitology Gastrointestinal Diseases - veterinary Goat Diseases - drug therapy Goat Diseases - parasitology Goats Haemonchus contortus Larva - drug effects Larva - physiology Nematoda - drug effects Nematoda - growth & development Nematoda - physiology Nematode Infections - drug therapy Nematode Infections - parasitology Nematode Infections - veterinary Ovum - drug effects Ovum - physiology Pasture contamination Phytomedicine Plant Extracts - pharmacology Plant Extracts - therapeutic use Sheep Sheep Diseases - drug therapy Sheep Diseases - parasitology Small ruminants Haemonchus contortus Pasture contamination Agavaceae Small ruminants Phytomedicine
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Summary:	[Display omitted] ► We evaluate Agave sisalana extract on sheep and goats nematodes. ► The results show a dose-dependent relationship. ► The best LC50 and LC95 occur in the LDT with 0.041 and 0.067mg/mL, respectively. ► The development and feeding inhibition on L1 are both 100% at a dose of 0.12mg/mL. ► A. sisalana action on L1 in the feces may reduce the pasture contamination. Active compounds from Agave sisalana with antiparasitic action against gastrointestinal nematodes (GINs) could be an alternative to diversify the range of parasite management methods in the livestock sector. The objective of this study was to evaluate the in vitro action of A. sisalana extract on the development of sheep and goat GINs. The extract, obtained from shredded sisal leaves, was utilized at various concentrations in the egg hatch test (EHT), larval development test (LDT), larval feeding inhibition test (LFIT) and adult motility test (AMT). The LC50 and LC95 in the EHT were 6.90 and 24.79mg/mL, in the LDT were 0.041 and 0.067mg/mL and in the LFIT were 0.053 and 0.24mg/mL, respectively, showing a dose-dependent relationship. The development and feeding inhibition on L1 were both 100% at a dose of 0.12mg/mL. In the AMT there was 100% inhibition at 75mg/mL after 24h of exposure. The extract of A. sisalana therefore demonstrated significant action on L1 at 0.12mg/mL. So, if part of the A. sisalana extract passes through the animal’s gastrointestinal system, this material can have a significant effect on the parasites in the feces. This is an interesting approach because it can drastically reduce the pasture contamination as well as the infection of herds.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0014-4894 1090-2449
DOI:	10.1016/j.exppara.2012.03.018