Search Results - "Machado, Carlos R."

The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications by Zingales, Bianca, Miles, Michael A., Campbell, David A., Tibayrenc, Michel, Macedo, Andrea M., Teixeira, Marta M.G., Schijman, Alejandro G., Llewellyn, Martin S., Lages-Silva, Eliane, Machado, Carlos R., Andrade, Sonia G., Sturm, Nancy R.

“…► We review the population structure of Trypanosoma cruzi, causative agent of Chagas disease. ► We provide information on the eco-epidemiology of T. cruzi…”
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Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages by Goes, Grazielle R, Rocha, Peter S, Diniz, Aline R S, Aguiar, Pedro H N, Machado, Carlos R, Vieira, Leda Q

“…During Trypanosoma cruzi infection, macrophages produce reactive oxygen species (ROS) in a process called respiratory burst. Several works have aimed to…”
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Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts by Lobo, Francisco P, Mota, Bruno E F, Pena, Sérgio D J, Azevedo, Vasco, Macedo, Andréa M, Tauch, Andreas, Machado, Carlos R, Franco, Glória R

“…Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is…”
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Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics by Trenaman, Anna, Hartley, Claire, Prorocic, Marko, Passos-Silva, Danielle G, van den Hoek, Moniek, Nechyporuk-Zloy, Volodymyr, Machado, Carlos R, McCulloch, Richard

“…Trypanosoma brucei survives in mammals through antigenic variation, which is driven by RAD51-directed homologous recombination of Variant Surface Glycoproteins…”
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Trypanosoma cruzi : Genetic Structure of Populations and Relevance of Genetic Variability to the Pathogenesis of Chagas Disease by Macedo, Andréa M, Machado, Carlos R, Oliveira, Riva P, Pena, Sérgio D J

“…Chagas disease, caused by the protozoan Trypanosoma cruzi , has a variable clinical course, ranging from symptomless infection to severe chronic disease with…”
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Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress by Grazielle-Silva, Viviane, Zeb, Tehseen Fatima, Bolderson, Jason, Campos, Priscila C, Miranda, Julia B, Alves, Ceres L, Machado, Carlos R, McCulloch, Richard, Teixeira, Santuza M R

“…DNA repair mechanisms are crucial for maintenance of the genome in all organisms, including parasites where successful infection is dependent both on genomic…”
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Vaccination With Recombinant Filamentous fd Phages Against Parasite Infection Requires TLR9 Expression by Gomes-Neto, João F, Sartorius, Rossella, Canto, Fábio B, Almeida, Thamyres S, Dias, André A, Barbosa, Carlos-Henrique D, Melo, Guilherme A, Oliveira, Ana Carolina, Aguiar, Pedro-Henrique N, Machado, Carlos R, de Matos Guedes, Herbert L, Santiago, Marcelo F, Nóbrega, Alberto, De Berardinis, Piergiuseppe, Bellio, Maria

“…Recombinant filamentous bacteriophages (r ) expressing antigenic peptides were shown to induce cell-mediated immune responses in the absence of added adjuvant,…”
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The MHC gene region of murine hosts influences the differential tissue tropism of infecting Trypanosoma cruzi strains by Freitas, Jorge M, Andrade, Luciana O, Pires, Simone F, Lima, Ricardo, Chiari, Egler, Santos, Ricardo R, Soares, Milena, Machado, Carlos R, Franco, Gloria R, Pena, Sergio D J, Macedo, Andrea M

“…We have previously demonstrated that both parasite genetic variability and host genetic background were important in determining the differential tissue…”
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ADJUVANTS IN FUNGICIDE SPRAYING IN WHEAT AND SOYBEAN CROPS by Garcia, Luiz C., Machado Júnior, Carlos R., Bochnia, Giovana P., Weirich Neto, Pedro H., Raetano, Carlos G.

“…ABSTRACT The objective of this study was to determine whether the combination of adjuvants to fungicides significantly alters the spray physicochemical…”
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Molecular characterization of the Schistosoma mansoni zinc finger protein SmZF1 as a transcription factor by Drummond, Marcela G, Calzavara-Silva, Carlos E, D'Astolfo, Diego S, Cardoso, Fernanda C, Rajão, Matheus A, Mourão, Marina M, Gava, Elisandra, Oliveira, Sérgio C, Macedo, Andréa M, Machado, Carlos R, Pena, Sérgio D J, Kitten, Gregory T, Franco, Glória R

“…During its development, the parasite Schistosoma mansoni is exposed to different environments and undergoes many morphological and physiological…”
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Nucleotide excision repair in Trypanosoma brucei: specialization of transcription‐coupled repair due to multigenic transcription by Machado, Carlos R., Vieira‐da‐Rocha, João P., Mendes, Isabela Cecilia, Rajão, Matheus A., Marcello, Lucio, Bitar, Mainá, Drummond, Marcela G., Grynberg, Priscila, Oliveira, Denise A. A., Marques, Catarina, Van Houten, Ben, McCulloch, Richard

“…Summary Nucleotide excision repair (NER) is a highly conserved genome repair pathway acting on helix distorting DNA lesions. NER is divided into two…”
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Leishmania major and Trypanosoma cruzi present distinct DNA damage responses by Garcia, Juliana B.F., Rocha, João P.Vieira da, Costa-Silva, Héllida M., Alves, Ceres L., Machado, Carlos R., Cruz, Angela K.

“…[Display omitted] •T. cruzi efficiently repair double-strand breaks in DNA.•L. major presents higher radiosensitivity than T. cruzi.•L. major exhibits higher…”
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Analysis of trauma admission data at an urban hospital in Maputo, Mozambique by Taibo, Cátia Luciana Abdulfattáhe, Moon, Troy D., Joaquim, Orvalho A., Machado, Carlos R., Merchant, Amina, McQueen, Kelly, Sidat, Mohsin, Folgosa, Elena

“…Background Trauma is a major public health concern. Worldwide, injuries resulted in 4.8 million deaths in 2013, an increase of 11 % since 1990. The majority of…”
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Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome system by Cerqueira, Paula G., Passos-Silva, Danielle G., Vieira-da-Rocha, João P., Mendes, Isabela Cecilia, de Oliveira, Karla A., Oliveira, Camila F.B., Vilela, Liza F.F., Nagem, Ronaldo A.P., Cardoso, Joseane, Nardelli, Sheila C., Krieger, Marco A., Franco, Glória R., Macedo, Andrea M., Pena, Sérgio D.J., Schenkman, Sérgio, Gomes, Dawidson A., Guerra-Sá, Renata, Machado, Carlos R.

“…[Display omitted] •Proteasome-mediated proteolysis is important to T. cruzi IR-induced damage response.•20S proteasome-mediated proteolysis role can be…”
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Functional complementation of a yeast knockout strain by Schistosoma mansoni Rho1 GTPase in the presence of caffeine, an agent that affects mutants defective in the protein kinase C signal transduction pathway by Aguiar, Pedro H N de, Santos, Débora N, Lobo, Francisco P, Santos, Túlio M, Macedo, Andréa M, Pena, Sérgio D J, Machado, Carlos R, Franco, Glória R

“…In a previous study, the Schistosoma mansoni Rho1 protein was able to complement Rho1 null mutant Saccharomyces cerevisiae cells at restrictive temperatures…”
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Analysis of DNA Exchange Using Thymidine Analogs (ADExTA) in Trypanosoma cruzi by da Silva, Marcelo S, Marin, Paula A, Repolês, Bruno M, Elias, Maria C, Machado, Carlos R

“…is a protozoan parasite belonging to the Trypanosomatidae family. Although the trypanosomatids multiply predominantly by clonal generation, the presence of DNA…”
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Cloning of a cDNA from Arabidopsis thaliana homologous to the human XPB gene by Ribeiro, Denise T, Machado, Carlos R, Costa, Renata M.A, Praekelt, Uta M, Van Sluys, Marie-Anne, Menck, Carlos F.M

“…The human gene XPB, defective in xeroderma pigmentosum patients complementation group B, encodes a DNA helicase involved in several DNA metabolic pathways,…”
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Identification of a new Schistosoma mansoni SMYB1 partner: putative roles in RNA metabolism by Rocha, Elizângela A, Valadão, Analina F, Rezende, Cíntia M, Dias, Silvia Regina Costa, Macedo, Andréa M, Machado, Carlos R, Fantappié, Marcelo R, Rumjanek, Franklin D, Goes, Alfredo M, Gomes, Dawidson A, Loverde, Philip T, Drummond, Marcela G, Franco, Glória R

“…SMYB1 is a Schistosoma mansoni protein highly similar to members of the Y-box binding protein family. Similar to other homologues, SMYB1 is able to bind…”
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Evaluation of the Schistosoma mansoni Y-box-binding protein (SMYB1) potential as a vaccine candidate against schistosomiasis by Dias, Sílvia R C, Boroni, Mariana, Rocha, Elizângela A, Dias, Thomaz L, de Laet Souza, Daniela, Oliveira, Fabrício M S, Bitar, Mainá, Macedo, Andrea M, Machado, Carlos R, Caliari, Marcelo V, Franco, Glória R

“…Schistosomiasis is a neglected tropical disease, and after malaria, is the second most important tropical disease in public health. A vaccine that reduces…”
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The spliced leader trans-splicing mechanism in different organisms: molecular details and possible biological roles by Bitar, Mainá, Boroni, Mariana, Macedo, Andréa M, Machado, Carlos R, Franco, Glória R

“…THE SPLICED LEADER (SL) IS A GENE THAT GENERATES A FUNCTIONAL NCRNA THAT IS COMPOSED OF TWO REGIONS: an intronic region of unknown function (SLi) and an exonic…”
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