Search Results - "Machacek, Michelle R."

Predicting the Stereochemistry of Diphenylphosphino Benzoic Acid (DPPBA)-Based Palladium-Catalyzed Asymmetric Allylic Alkylation Reactions:  A Working Model by Trost, Barry M, Machacek, Michelle R, Aponick, Aaron

“…Palladium-catalyzed asymmetric allylic alkylation has proven to be a powerful method for the preparation of a wide variety of chiral compounds and the rapid…”
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Sequential Ru−Pd Catalysis:  A Two-Catalyst One-Pot Protocol for the Synthesis of N- and O-Heterocycles by Trost, Barry M, Machacek, Michelle R, Faulk, Brian D

“…An atom economic, selective, and highly practical two-metal one-pot synthesis of heterocycles has been developed that efficiently affords enantio- and…”
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Ruthenium-Catalyzed Vinylsilane Synthesis and Cross-Coupling as a Selective Approach to Alkenes:  Benzyldimethylsilyl as a Robust Vinylmetal Functionality by Trost, Barry M, Machacek, Michelle R, Ball, Zachary T

“…Ruthenium-catalyzed alkyne hydrosilylation or silyl-alkyne Alder ene reactions provide entry into benzyldimethylsilyl (BDMS)-substituted alkenes. The…”
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Development of Aliphatic Alcohols as Nucleophiles for Palladium-Catalyzed DYKAT Reactions:  Total Synthesis of (+)-Hippospongic Acid A by Trost, Barry M, Machacek, Michelle R, Tsui, Hong C

“…The ability to use aliphatic alcohols as competent nucleophiles in the palladium-catalyzed dynamic kinetic asymmetric transformation of Baylis−Hillman adducts…”
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An Efficient One-Pot Enantio- and Diastereoselective Synthesis of Heterocycles by Trost, Barry M., Machacek, Michelle R.

“…Five‐ and six‐membered nitrogen and oxygen heterocycles are accessible from two acyclic precursors in a one‐pot reaction that comprises a Ru‐catalyzed ene–yne…”
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Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity by Kawamura, Shuhei, Palte, Rachel L., Kim, Hai-Young, Saurí, Josep, Sondey, Christopher, Mansueto, My S., Altman, Michael D., Machacek, Michelle R.

“…[Display omitted] Synthesis of medium-sized rings is known to be challenging due to high transannular strain especially for 9- and 10-membered rings. Herein we…”
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NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes by Fradera, Xavier, Reutershan, Michael H., Machacek, Michelle R., Trotter, B. Wesley, McCoy, Mark A.

“…We present an automated NMR‐guided docking workflow that can be used to generate models of protein‐ligand complexes based on data from NOE NMR experiments. The…”
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Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction by Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley

“…Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein–protein interactions (PPIs) is a challenging area of research. Despite the…”
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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer by Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R

“…Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the post-translational symmetric dimethylation of protein…”
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Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5) by Palte, Rachel L, Schneider, Sebastian E, Altman, Michael D, Hayes, Robert P, Kawamura, Shuhei, Lacey, Brian M, Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R

“…Protein arginine methyltransferase 5 (PRMT5) belongs to a family of enzymes that regulate the posttranslational modification of histones and other proteins via…”
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A one-step, multi-component reaction for the synthesis of fully substituted 5-amino-4-carboxamidthiazoles by Childers, Kaleen K., Haidle, Andrew M., Machacek, Michelle R., Rogers, J. Patrick, Romeo, Eric

“…[Display omitted] A novel multi-component reaction has been developed for the synthesis of fully substituted 5-amino-4-carboxamidthiazoles. Condensation of an…”
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A Poly(p-phenyleneethynylene) with a Highly Emissive Aggregated Phase by Deans, Robert, Kim, Jinsang, Machacek, Michelle R, Swager, Timothy M

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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors by Huang, Chunhui, Fischer, Christian, Machacek, Michelle R, Bogen, Stephane, Biftu, Tesfaye, Huang, Xianhai, Reutershan, Michael H, Otte, Ryan, Hong, Qingmei, Wu, Zhicai, Yu, Yang, Park, Min, Chen, Lei, Biju, Purakkattle, Knemeyer, Ian, Lu, Ping, Kochansky, Christopher J, Hicks, Michael Brendan, Liu, Yong, Helmy, Roy, Fradera, Xavier, Donofrio, Anthony, Close, Josh, Maddess, Matthew L, White, Catherine, Sloman, David L, Sciammetta, Nunzio, Lu, Jun, Gibeau, Craig, Simov, Vladimir, Zhang, Hongjun, Fuller, Peter, Witter, David

“…Mutant isocitrate dehydrogenase 1 (IDH1) has been identified as an attractive oncology target for which >70% of grade II and III gliomas and ∼10% of acute…”
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Update on lymphocyte specific kinase inhibitors: a patent survey by Martin, Matthew W, Machacek, Michelle R

“…Lck (p56(lck) or lymphocyte specific kinase) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic…”
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Racemic Synthesis of a Key 1,4-Dihydro-2 H -spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block by Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.

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Racemic Synthesis of a Key 1,4-Dihydro‑2H‑spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block by Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.

“…The synthesis of a key spiroamine building block for a medicinal chemistry program is described. Key innovations were a regioselective epoxide ring opening and…”
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An Efficient One-Pot Enantio- and Diastereoselective Synthesis of Heterocycles by Trost, Barry M., Machacek, Michelle R.

“…Fünf‐ und sechsgliedrige N‐ und O‐Heterocyclen werden durch eine Eintopfreaktion zweier acyclischer Substrate erhalten, die aus einer Ru‐katalysierten…”
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An Efficient One‐Pot Enantio‐ and Diastereoselective Synthesis of Heterocycles by Trost, Barry M., Machacek, Michelle R.

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