Search Results - "Mach, Lukas"

Single cell RNA sequencing sheds light on infiltrating T cells in idiopathic inflammatory myopathies by Yazdani, Momina, Mach, Lukas, Noseda, Michela

“…Idiopathic inflammatory myopathies (IIM), also referred to as “myositis,” are a group of heterogeneous autoimmune disorders characterised by muscle weakness,…”
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Plant cathepsin B, a versatile protease by Coppola, Marianna, Mach, Lukas, Gallois, Patrick

“…Plant proteases are essential enzymes that play key roles during crucial phases of plant life. Some proteases are mainly involved in general protein turnover…”
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Genome and transcriptome characterization of the glycoengineered Nicotiana benthamiana line ΔXT/FT by Schiavinato, Matteo, Strasser, Richard, Mach, Lukas, Dohm, Juliane C, Himmelbauer, Heinz

“…The allotetraploid tobacco species Nicotiana benthamiana native to Australia has become a popular host for recombinant protein production. Although its usage…”
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Characterizing the Link between Glycosylation State and Enzymatic Activity of the Endo-β1,4-glucanase KORRIGAN1 from Arabidopsis thaliana by Liebminger, Eva, Grass, Josephine, Altmann, Friedrich, Mach, Lukas, Strasser, Richard

“…Defects in N-glycosylation and N-glycan processing frequently cause alterations in plant cell wall architecture, including changes in the structure of…”
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Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level by Zhu, Rong, Canena, Daniel, Sikora, Mateusz, Klausberger, Miriam, Seferovic, Hannah, Mehdipour, Ahmad Reza, Hain, Lisa, Laurent, Elisabeth, Monteil, Vanessa, Wirnsberger, Gerald, Wieneke, Ralph, Tampé, Robert, Kienzl, Nikolaus F., Mach, Lukas, Mirazimi, Ali, Oh, Yoo Jin, Penninger, Josef M., Hummer, Gerhard, Hinterdorfer, Peter

“…Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron variant. We report that the Spike trimer acts as a highly dynamic molecular…”
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N-Glycosylation of the SARS-CoV-2 Receptor Binding Domain Is Important for Functional Expression in Plants by Shin, Yun-Ji, König-Beihammer, Julia, Vavra, Ulrike, Schwestka, Jennifer, Kienzl, Nikolaus F., Klausberger, Miriam, Laurent, Elisabeth, Grünwald-Gruber, Clemens, Vierlinger, Klemens, Hofner, Manuela, Margolin, Emmanuel, Weinhäusel, Andreas, Stöger, Eva, Mach, Lukas, Strasser, Richard

“…Nicotiana benthamiana is used worldwide as production host for recombinant proteins. Many recombinant proteins such as monoclonal antibodies, growth factors or…”
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Plant-based production of highly potent anti-HIV antibodies with engineered posttranslational modifications by Singh, Advaita Acarya, Pooe, Ofentse, Kwezi, Lusisizwe, Lotter-Stark, Therese, Stoychev, Stoyan H., Alexandra, Kabamba, Gerber, Isak, Bhiman, Jinal N., Vorster, Juan, Pauly, Michael, Zeitlin, Larry, Whaley, Kevin, Mach, Lukas, Steinkellner, Herta, Morris, Lynn, Tsekoa, Tsepo Lebiletsa, Chikwamba, Rachel

“…Broadly neutralising antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1), such as CAP256-VRC26 are being developed for HIV prevention and…”
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Mass + Retention Time = Structure:  A Strategy for the Analysis of N-Glycans by Carbon LC-ESI-MS and Its Application to Fibrin N-Glycans by Pabst, Martin, Bondili, Jayakumar Singh, Stadlmann, Johannes, Mach, Lukas, Altmann, Friedrich

“…Analysis of the numerous possible, often isobaric structures of protein-bound oligosaccharides calls for a high-performance two-dimensional method that…”
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Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics by Biniossek, Martin L., Niemer, Melanie, Maksimchuk, Ken, Mayer, Bettina, Fuchs, Julian, Huesgen, Pitter F., McCafferty, Dewey G., Turk, Boris, Fritz, Guenther, Mayer, Jens, Haecker, Georg, Mach, Lukas, Schilling, Oliver

“…We present protease specificity profiling based on quantitative proteomics in combination with proteome-derived peptide libraries. Peptide libraries are…”
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Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation by Mach, Lukas, Bedanova, Helena, Soucek, Miroslav, Karpisek, Michal, Nemec, Petr, Orban, Marek

“…Abstract Background & aims Epicardial adipose tissue (EAT) is a source of a number of cytokines which could act in the pathogenesis of coronary artery disease…”
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Glycan modulation and sulfoengineering of anti–HIV-1 monoclonal antibody PG9 in plants by Loos, Andreas, Gach, Johannes S., Hackl, Thomas, Maresch, Daniel, Henkel, Theresa, Porodko, Andreas, Bui-Minh, Duc, Sommeregger, Wolfgang, Wozniak-Knopp, Gordana, Forthal, Donald N., Altmann, Friedrich, Steinkellner, Herta, Mach, Lukas

“…Broadly neutralizing anti–HIV-1 monoclonal antibodies, such as PG9, and its derivative RSH hold great promise in AIDS therapy and prevention. An important…”
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Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level by Zhu, Rong, Canena, Daniel, Sikora, Mateusz, Klausberger, Miriam, Seferovic, Hannah, Mehdipour, Ahmad Reza, Hain, Lisa, Laurent, Elisabeth, Monteil, Vanessa, Wirnsberger, Gerald, Wieneke, Ralph, Tampé, Robert, Kienzl, Nikolaus F., Mach, Lukas, Mirazimi, Ali, Oh, Yoo Jin, Penninger, Josef M., Hummer, Gerhard, Hinterdorfer, Peter

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Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor by Capraz, Tümay, Kienzl, Nikolaus F, Laurent, Elisabeth, Perthold, Jan W, Föderl-Höbenreich, Esther, Grünwald-Gruber, Clemens, Maresch, Daniel, Monteil, Vanessa, Niederhöfer, Janine, Wirnsberger, Gerald, Mirazimi, Ali, Zatloukal, Kurt, Mach, Lukas, Penninger, Josef M, Oostenbrink, Chris, Stadlmann, Johannes

“…Infection and viral entry of SARS-CoV-2 crucially depends on the binding of its Spike protein to angiotensin converting enzyme 2 (ACE2) presented on host…”
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Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9 by Singh, Advaita Acarya, Pillay, Priyen, Naicker, Previn, Alexandre, Kabamba, Malatji, Kanyane, Mach, Lukas, Steinkellner, Herta, Vorster, Juan, Chikwamba, Rachel, Tsekoa, Tsepo L.

“…The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana , including the induction and accumulation of…”
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Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana by Gu, Christian, Shabab, Mohammed, Strasser, Richard, Wolters, Pieter J, Shindo, Takayuki, Niemer, Melanie, Kaschani, Farnusch, Mach, Lukas, van der Hoorn, Renier A L

“…RD21-like proteases are ubiquitous, plant-specific papain-like proteases typified by carrying a C-terminal granulin domain. RD21-like proteases are involved in…”
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Arrhythmic Risk Stratification in Non-ischemic Cardiomyopathy Based on Cardiovascular Magnetic Resonance Measures of Myocardial Fibrosis and Gray Zone Fibrosis by Hammersley, Daniel, Zegard, Abbasin, Androulakis, Emmanuel, Jones, Richard, Okafor, Osita, Hatipoglu, Suzan, Mach, Lukas, Lota, Amrit, Khalique, Zohya, Marvao, Antonio De, Baruah, Resham, Guha, Kaushik, Ware, James, Tayal, Upasana, Pennell, Dudley, Halliday, Brian, Qiu, Tian, Prasad, Sanjay, Leyva, Francisco

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Unique β1,3-Galactosyltransferase Is Indispensable for the Biosynthesis of N-Glycans Containing Lewis a Structures in Arabidopsis thaliana by Strasser, Richard, Bondili, Jayakumar Singh, Vavra, Ulrike, Schoberer, Jennifer, Svoboda, Barbara, Glössl, Josef, Léonard, Renaud, Stadlmann, Johannes, Altmann, Friedrich, Steinkellner, Herta, Mach, Lukas

“…In plants, the only known outer-chain elongation of complex N-glycans is the formation of Lewis a [Fucα1-4(Galβ1-3)GlcNAc-R] structures. This process involves…”
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Arginine/Lysine Residues in the Cytoplasmic Tail Promote ER Export of Plant Glycosylation Enzymes by Schoberer, Jennifer, Vavra, Ulrike, Stadlmann, Johannes, Hawes, Chris, Mach, Lukas, Steinkellner, Herta, Strasser, Richard

“…Plant N-glycan processing enzymes are arranged along the early secretory pathway, forming an assembly line to facilitate the step-by-step modification of…”
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Impact of Specific N-Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological Assays by Schwestka, Jennifer, König-Beihammer, Julia, Shin, Yun-Ji, Vavra, Ulrike, Kienzl, Nikolaus F., Grünwald-Gruber, Clemens, Maresch, Daniel, Klausberger, Miriam, Laurent, Elisabeth, Stadler, Maria, Manhart, Gabriele, Huber, Jasmin, Hofner, Manuela, Vierlinger, Klemens, Weinhäusel, Andreas, Swoboda, Ines, Binder, Christoph J., Gerner, Wilhelm, Grebien, Florian, Altmann, Friedrich, Mach, Lukas, Stöger, Eva, Strasser, Richard

“…The receptor binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in the virus-host cell interaction, and viral infection. The RBD is a major…”
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In planta deglycosylation improves the SARS-CoV-2 neutralization activity of recombinant ACE2-Fc by Izadi, Shiva, Vavra, Ulrike, Melnik, Stanislav, Grünwald-Gruber, Clemens, Föderl-Höbenreich, Esther, Sack, Markus, Zatloukal, Kurt, Glössl, Josef, Stöger, Eva, Mach, Lukas, Castilho, Alexandra, Strasser, Richard

“…SARS-CoV-2 infects human cells via binding of the viral spike glycoprotein to its main cellular receptor, angiotensin-converting enzyme 2 (ACE2). The spike…”
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