Search Results - "Macfawn, Ian"

Type I interferons and related pathways in cell senescence by Frisch, Steven M., MacFawn, Ian P.

“…This review article addresses the largely unanticipated convergence of two landmark discoveries. The first is the discovery of interferons, critical signaling…”
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Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes by Karapetyan, Lilit, AbuShukair, Hassan M, Li, Aofei, Knight, Andrew, Al Bzour, Ayah Nedal, MacFawn, Ian P, Thompson, Zachary J, Chen, Ann, Yang, Xi, Dadey, Rebekah, Karunamurthy, Arivarasan, De Stefano, Danielle Vargas, Sander, Cindy, Kunning, Sheryl R, Najjar, Yana G, Davar, Diwakar, Luke, Jason J, Gooding, William, Bruno, Tullia C, Kirkwood, John M, Storkus, Walter J

“…Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In the…”
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Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells by Vito, Alyssa, Salem, Omar, El-Sayes, Nader, MacFawn, Ian P., Portillo, Ana L., Milne, Katy, Harrington, Danielle, Ashkar, Ali A., Wan, Yonghong, Workenhe, Samuel T., Nelson, Brad H., Bruno, Tullia C., Mossman, Karen L.

“…Triple negative breast cancer holds a dismal clinical outcome and as such, patients routinely undergo aggressive, highly toxic treatment regimens. Clinical…”
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Abstract 3928: N-cadherin(CDH2) expression in mesenchymal glioblastoma modulates radiation sensitivity by Cifarelli, Christopher P., Vargo, J. Austin, MacFawn, Ian, Frisch, Steven M.

“…Background: Radiation is a mainstay of treatment in patients diagnosed with glioblastoma. Despite maximal surgical and chemo-radiotherapeutic treatment, the…”
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Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence by MacFawn, Ian, Farris, Joshua, Pifer, Phillip, Margaryan, Naira V., Akhter, Halima, Wang, Lei, Dziadowicz, Sebastian, Denvir, James, Hu, Gangqing, Frisch, Steven M.

“…Type-I and -III interferons play a central role in immune rejection of pathogens and tumors, thus promoting immunogenicity and suppressing tumor recurrence…”
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Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum: Outcomes for patients with melanoma by Karapetyan, Lilit, Abushukair, Hassan Mohammed, Li, Aofei, Knight, Andrew David, Al-Bzour, Ayah N., Macfawn, Ian, Thompson, Zachary, Chen, Ann, Dadey, Rebekah E., Karunamurthy, Arivarasan, Vargas De Stefano, Danielle, Sander, Cindy, Kunning, Sheryl, Najjar, Yana G., Davar, Diwakar, Luke, Jason J., Gooding, William E., Bruno, Tullia C., Kirkwood, John M. M., Storkus, Walter J.

“…9565 Background: Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor immune…”
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Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers by MacFawn, Ian, Wilson, Hannah, Selth, Luke A., Leighton, Ian, Serebriiskii, Ilya, Bleackley, R. Christopher, Elzamzamy, Osama, Farris, Joshua, Pifer, Phillip M., Richer, Jennifer, Frisch, Steven M.

“…•GRHL2 is a master programmer of the epithelial phenotype that sensitized cells to NK killing at the level of NK-target cell synaptogenesis.•Sensitization was…”
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1451 The impact of the tumor microenvironment on B cell infiltrate and tertiary lymphoid structures in high grade serous ovarian cancer patients by MacFawn, Ian, Ruffin, Ayana, Kunning, Sheryl, Magnon, Grant, Soong, Rinda, Lampenfeld, Caleb, Huda Atiya, Orellana, Taylor, Coffman, Lan, Bruno, Tullia

“…BackgroundB cell infiltrate is a common feature of High Grade Serous Ovarian Cancer (HGSOC) and ~15% of patients contain B and T cell-rich tertiary lymphoid…”
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Grainyhead-Like 2 Sensitizes Cells to Natural Killer Cell Cytotoxicity and Promotes the Interferon Response by MacFawn, Ian Philip

“…Our research determined that the epithelial master transcription factor Grainyhead-like 2 (GRHL2) promotes sensitivity to Natural Killer (NK) cell-mediated…”
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