Search Results - "Macfarlane, James"

Non cystic fibrosis bronchiectasis: A longitudinal retrospective observational cohort study of Pseudomonas persistence and resistance by McDonnell, Melissa J, Jary, Hannah R, Perry, Audrey, MacFarlane, James G, Hester, Katy L.M, Small, Therese, Molyneux, Catherine, Perry, John D, Walton, Katherine E, De Soyza, Anthony

“…Summary Background The hallmark of non-cystic fibrosis bronchiectasis is recurrent bronchial infection, yet there are significant gaps in our understanding of…”
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Photophysiology and albedo-changing potential of the ice algal community on the surface of the Greenland ice sheet by Yallop, Marian L, Anesio, Alexandre M, Perkins, Rupert G, Cook, Joseph, Telling, Jon, Fagan, Daniel, MacFarlane, James, Stibal, Marek, Barker, Gary, Bellas, Chris, Hodson, Andy, Tranter, Martyn, Wadham, Jemma, Roberts, Nicholas W

“…Darkening of parts of the Greenland ice sheet surface during the summer months leads to reduced albedo and increased melting. Here we show that heavily…”
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Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis by Pinder, Emma M, Rostron, Anthony J, Hellyer, Thomas P, Ruchaud-Sparagano, Marie-Helene, Scott, Jonathan, Macfarlane, James G, Wiscombe, Sarah, Widdrington, John D, Roy, Alistair I, Linnett, Vanessa C, Baudouin, Simon V, Wright, Stephen E, Chadwick, Thomas, Fouweather, Tony, Juss, Jatinder K, Chilvers, Edwin R, Bowett, Susan A, Parker, Jennie, McAuley, Daniel F, Conway Morris, Andrew, Simpson, A John

“…Critically ill patients with impaired neutrophil phagocytosis have significantly increased risk of nosocomial infection. Granulocyte-macrophage…”
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Hypnotics in Insomnia: The Experience of Zolpidem by MacFarlane, James, PhD, Morin, Charles M., PhD, Montplaisir, Jacques, MD, PhD

“…Abstract Purpose One of the most commonly prescribed medications to treat insomnia is zolpidem, a nonbenzodiazepine compound that is available as an…”
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Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury by Macfarlane, James G, Dorward, David A, Ruchaud-Sparagano, Marie-Hélène, Scott, Jonathan, Lucas, Christopher D, Rossi, Adriano G, Simpson, A John

“…Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation…”
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Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia by Hellyer, Thomas P, Morris, Andrew Conway, McAuley, Daniel F, Walsh, Timothy S, Anderson, Niall H, Singh, Suveer, Dark, Paul, Roy, Alistair I, Baudouin, Simon V, Wright, Stephen E, Perkins, Gavin D, Kefala, Kallirroi, Jeffels, Melinda, McMullan, Ronan, O'Kane, Cecilia M, Spencer, Craig, Laha, Shondipon, Robin, Nicole, Gossain, Savita, Gould, Kate, Ruchaud-Sparagano, Marie-Hélène, Scott, Jonathan, Browne, Emma M, MacFarlane, James G, Wiscombe, Sarah, Widdrington, John D, Dimmick, Ian, Laurenson, Ian F, Nauwelaers, Frans, Simpson, A John

“…Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in…”
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Skin tribology in sport by MacFarlane, Maxwell James, Theobald, Peter

“…This review describes the principles of skin friction and wear for the benefit of sports scientists, engineers and clinicians. Skin exhibits complex behaviour,…”
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Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction by Gillett, Daniel, Senanayake, Russell, MacFarlane, James, van der Meulen, Merel, Koulouri, Olympia, Powlson, Andrew S., Crawford, Rosy, Gillett, Bethany, Bird, Nick, Heard, Sarah, Kolias, Angelos, Mannion, Richard, Aloj, Luigi, Mendichovszky, Iosif A., Cheow, Heok, Bashari, Waiel A., Gurnell, Mark

“…Background Pituitary adenomas (PA) affect ~ 1:1200 of the population and can cause a wide range of symptoms due to hormone over-secretion, loss of normal…”
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Development of a bespoke phantom to optimize molecular PET imaging of pituitary tumors by Gillett, Daniel, Marsden, Daniel, Crawford, Rosy, Ballout, Safia, MacFarlane, James, van der Meulen, Merel, Gillett, Bethany, Bird, Nick, Heard, Sarah, Powlson, Andrew S., Santarius, Thomas, Mannion, Richard, Kolias, Angelos, Harper, Ines, Mendichovszky, Iosif A., Aloj, Luigi, Cheow, Heok, Bashari, Waiel, Koulouri, Olympia, Gurnell, Mark

“…Background Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not…”
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Methods of 3D printing models of pituitary tumors by Gillett, Daniel, Bashari, Waiel, Senanayake, Russell, Marsden, Daniel, Koulouri, Olympia, MacFarlane, James, van der Meulen, Merel, Powlson, Andrew S., Mendichovszky, Iosif A., Cheow, Heok, Bird, Nick, Kolias, Angelos, Mannion, Richard, Gurnell, Mark

“…Background Pituitary adenomas can give rise to a variety of clinical disorders and surgery is often the primary treatment option. However, preoperative…”
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Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by beta 2-agonists, corticosteroids, and critical illness by Scott, Jonathan, Harris, Graham J, Pinder, Emma M, Macfarlane, James G, Hellyer, Thomas P, Rostron, Anthony J, Conway Morris, Andrew, Thickett, David R, Perkins, Gavin D, McAuley, Daniel F, Widdrington, John D, Wiscombe, Sarah, Baudouin, Simon V, Roy, Alistair I, Linnett, Vanessa C, Wright, Stephen E, Ruchaud-Sparagano, Marie-Helene, Simpson, AJohn

“…Background Neutrophils play a role in the pathogenesis of asthma, chronic obstructive pulmonary disease, and pulmonary infection. Impaired neutrophil…”
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Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis by Ruchaud-Sparagano, Marie-Hélène, Gertig, Helen, Hester, Katy L.M., Macfarlane, James G., Corris, Paul A., Simpson, A. John, De Soyza, Anthony

“…Background and objective Neutrophils are consistently found in inflamed and infected airways in idiopathic bronchiectasis, but relatively little is known about…”
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Incidence of Euglycemic Diabetic Ketoacidosis in Adults With Type I Diabetes in the United Kingdom Before the Widespread Use of Sodium Glucose Cotransporter 2 Inhibitors by Macfarlane, James, Dhatariya, Ketan

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Low serum mannose-binding lectin level is not associated with disease severity in non-cystic fibrosis bronchiectasis by Macfarlane, James G, Jary, Hannah, Hester, Katharine L M, McAlinden, Paul, Wake, Jonathan, Small, Therese, Walton, Kathy E, Spickett, Gavin, De Soyza, Anthony

“…Deficiency of mannose-binding lectin (MBL), a serum protein involved in killing and promoting phagocytosis of pathogens, is associated with respiratory…”
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Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2 -agonists, corticosteroids, and critical illness by Scott, Jonathan, MPhil, Harris, Graham J., MBBS, MRes, Pinder, Emma M., MRCP(UK), Macfarlane, James G., MRCP(UK), Hellyer, Thomas P., MRCP(UK), Rostron, Anthony J., PhD, FRCP, Conway Morris, Andrew, PhD, FRCA, Thickett, David R., DM, FRCP, Perkins, Gavin D., MD, FRCP, McAuley, Daniel F., MD, FRCP, Widdrington, John D., MBBS, MRes, Wiscombe, Sarah, MBChB, Baudouin, Simon V., MD, FRCP, Roy, Alistair I., FFICM, Linnett, Vanessa C., FRCA, Wright, Stephen E., FRCA, Ruchaud-Sparagano, Marie-Hélène, PhD, Simpson, A. John, PhD, FRCP(Edin)

“…Background Neutrophils play a role in the pathogenesis of asthma, chronic obstructive pulmonary disease, and pulmonary infection. Impaired neutrophil…”
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Incidence of Euglycemic Diabetic Ketoacidosis in Adults With Type 1 Diabetes in the United Kingdom Before the Widespread Use of Sodium Glucose Cotransporter 2 Inhibitors by Macfarlane, James, Dhatariya, Ketan

“…To the Editor: Diabetic ketoacidosis (DKA) is a potentially life-threatening condition characterized most frequently by the presence of a glucose level greater…”
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A sanguine experience by Avinash Aujayeb, James Macfarlane, Simon Fearby, Sarah Haney, Jeanette Raine, Jonathan Miller, Mark Weatherhead

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Growth hormone receptor antagonist pegvisomant and its role in the medical therapy of growth hormone excess by MacFarlane, James, Korbonits, Márta

“…Pegvisomant is a growth-hormone (GH) receptor antagonist that prevents the formation of the active heterotrimer of the dimerised GH receptor and the GH…”
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Low serum 25‐hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID‐19 are associated with greater disease severity by Panagiotou, Grigorios, Tee, Su Ann, Ihsan, Yasir, Athar, Waseem, Marchitelli, Gabriella, Kelly, Donna, Boot, Christopher S., Stock, Nadia, Macfarlane, James, Martineau, Adrian R., Burns, Graham, Quinton, Richard

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0559 Treatment of Obstructive Sleep Apnea with Continuous Negative External Pressure by Blackman, Adam, MacFarlane, James, Rose, Richard

“…Introduction: Introduction cNEP is a novel treatment for OSA that involves external application of negative pressure over the upper airway via a silicone…”
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