Search Results - "Macfarlan, Todd S."

The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution by Yang, Peng, Wang, Yixuan, Macfarlan, Todd S.

“…Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) make up the largest family of transcription factors in humans. These proteins emerged in the last…”
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Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory Repertoire by Thompson, Peter J., Macfarlan, Todd S., Lorincz, Matthew C.

“…The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR) retrotransposons, begins with transcription by RNA polymerase II…”
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The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals by Bruno, Melania, Mahgoub, Mohamed, Macfarlan, Todd S

“…Nearly half of the human genome consists of endogenous retroelements (EREs) and their genetic remnants, a small fraction of which carry the potential to…”
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Ten things you should know about transposable elements by Bourque, Guillaume, Burns, Kathleen H, Gehring, Mary, Gorbunova, Vera, Seluanov, Andrei, Hammell, Molly, Imbeault, Michaël, Izsvák, Zsuzsanna, Levin, Henry L, Macfarlan, Todd S, Mager, Dixie L, Feschotte, Cédric

“…Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a…”
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Endogenous Retroviruses Drive Lineage-Specific Regulatory Evolution across Primate and Rodent Placentae by Sun, Ming-an, Wolf, Gernot, Wang, Yejun, Senft, Anna D, Ralls, Sherry, Jin, Jinpu, Dunn-Fletcher, Caitlin E, Muglia, Louis J, Macfarlan, Todd S

“…Abstract In mammals, the placenta mediates maternal–fetal nutrient and waste exchange and acts in an immunomodulatory way to facilitate maternal–fetal…”
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Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length by Dunn-Fletcher, Caitlin E, Muglia, Lisa M, Pavlicev, Mihaela, Wolf, Gernot, Sun, Ming-An, Hu, Yueh-Chiang, Huffman, Elizabeth, Tumukuntala, Shivani, Thiele, Katri, Mukherjee, Amrita, Zoubovsky, Sandra, Zhang, Xuzhe, Swaggart, Kayleigh A, Lamm, Katherine Y Bezold, Jones, Helen, Macfarlan, Todd S, Muglia, Louis J

“…Pregnancy and parturition are intricately regulated to ensure successful reproductive outcomes. However, the factors that control gestational length in humans…”
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KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage by Wolf, Gernot, de Iaco, Alberto, Sun, Ming-An, Bruno, Melania, Tinkham, Matthew, Hoang, Don, Mitra, Apratim, Ralls, Sherry, Trono, Didier, Macfarlan, Todd S

“…The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs),…”
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The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses by Wolf, Gernot, Yang, Peng, Füchtbauer, Annette C, Füchtbauer, Ernst-Martin, Silva, Andreia M, Park, Chungoo, Wu, Warren, Nielsen, Anders L, Pedersen, Finn S, Macfarlan, Todd S

“…Retroviruses have been invading mammalian germlines for millions of years, accumulating in the form of endogenous retroviruses (ERVs) that account for nearly…”
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KRAB zinc finger protein diversification drives mammalian interindividual methylation variability by Bertozzi, Tessa M., Elmer, Jessica L., Macfarlan, Todd S., Ferguson-Smith, Anne C.

“…Most transposable elements (TEs) in the mouse genome are heavily modified by DNA methylation and repressive histone modifications. However, a subset of TEs…”
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Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family by Wolf, Gernot, Greenberg, David, Macfarlan, Todd S

“…Tandem C2H2-type zinc finger proteins (ZFPs) constitute the largest transcription factor family in animals. Tandem-ZFPs bind DNA in a sequence-specific manner…”
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Regulation of endogenous retrovirus-derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells by Du, Cui, Jiang, Jing, Li, Yuzhuo, Yu, Miao, Jin, Jian, Chen, Shuai, Fan, Hairui, Macfarlan, Todd S, Cao, Bin, Sun, Ming-An

“…The placenta is an organ with extraordinary phenotypic diversity in eutherian mammals. Recent evidence suggests that numerous human placental enhancers are…”
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LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control by Wang, Jianxun, Telese, Francesca, Tan, Yuliang, Li, Wenbo, Jin, Chunyu, He, Xin, Basnet, Harihar, Ma, Qi, Merkurjev, Daria, Zhu, Xiaoyan, Liu, Zhijie, Zhang, Jie, Ohgi, Kenny, Taylor, Havilah, White, Ryan R, Tazearslan, Cagdas, Suh, Yousin, Macfarlan, Todd S, Pfaff, Samuel L, Rosenfeld, Michael G

“…The authors show that the neuron-specific LSD1 variant (LSD1n) promotes transcription initiation and elongation in response to neuronal activity. LSD1n is…”
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Revealing the Complexity of Retroviral Repression by Wolf, Gernot, Macfarlan, Todd S.

“…Retroviral restriction is a complex phenomenon that, despite remarkable recent progress, is far from being well understood. In this Preview, we introduce an…”
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Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A by Macfarlan, Todd S, Gifford, Wesley D, Agarwal, Saurabh, Driscoll, Shawn, Lettieri, Karen, Wang, Jianxun, Andrews, Shane E, Franco, Laura, Rosenfeld, Michael G, Ren, Bing, Pfaff, Samuel L

“…Endogenous retroviruses (ERVs) constitute a substantial portion of mammalian genomes, and their retrotransposition activity helped to drive genetic variation,…”
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A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568 by Yang, Peng, Wang, Yixuan, Hoang, Don, Tinkham, Matthew, Patel, Anamika, Sun, Ming-An, Wolf, Gernot, Baker, Mairead, Chien, Huan-Chieh, Lai, Kuan-Yu Nick, Cheng, Xiaodong, Shen, Che-Kun James, Macfarlan, Todd S.

“…Insulin-like growth factor 2 (IGF2) is the major fetal growth hormone in mammals. We identify zinc finger protein 568 (ZFP568), a member of the rapidly…”
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TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells by Rowe, Helen M, Kapopoulou, Adamandia, Corsinotti, Andrea, Fasching, Liana, Macfarlan, Todd S, Tarabay, Yara, Viville, Stéphane, Jakobsson, Johan, Pfaff, Samuel L, Trono, Didier

“…TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process…”
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Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice by Mahgoub, Mohamed, Paiano, Jacob, Bruno, Melania, Wu, Wei, Pathuri, Sarath, Zhang, Xing, Ralls, Sherry, Cheng, Xiaodong, Nussenzweig, André, Macfarlan, Todd S

“…Meiotic crossovers result from homology-directed repair of DNA double-strand breaks (DSBs). Unlike yeast and plants, where DSBs are generated near gene…”
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Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally by Wasson, Jadiel A, Simon, Ashley K, Myrick, Dexter A, Wolf, Gernot, Driscoll, Shawn, Pfaff, Samuel L, Macfarlan, Todd S, Katz, David J

“…Somatic cell nuclear transfer has established that the oocyte contains maternal factors with epigenetic reprogramming capacity. Yet the identity and function…”
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Local compartment changes and regulatory landscape alterations in histone H1-depleted cells by Geeven, Geert, Zhu, Yun, Kim, Byung Ju, Bartholdy, Boris A, Yang, Seung-Min, Macfarlan, Todd S, Gifford, Wesley D, Pfaff, Samuel L, Verstegen, Marjon J A M, Pinto, Hugo, Vermunt, Marit W, Creyghton, Menno P, Wijchers, Patrick J, Stamatoyannopoulos, John A, Skoultchi, Arthur I, de Laat, Wouter

“…Linker histone H1 is a core chromatin component that binds to nucleosome core particles and the linker DNA between nucleosomes. It has been implicated in…”
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Transposable elements shape the evolution of mammalian development by Senft, Anna D., Macfarlan, Todd S.

“…Transposable elements (TEs) promote genetic innovation but also threaten genome stability. Despite multiple layers of host defence, TEs actively shape…”
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