New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin's lymphoma in the Brazilian Amazon

Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization. This study described a case report, molecular epidemiology, the phylogenetic relationship, al...

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Published in:	Annals of clinical microbiology and antimicrobials Vol. 19; no. 1; p. 20
Main Authors:	Silva, Lucyane Mendes, Ferreira, William Antunes, Filho, Roberto Alexandre Alves Barbosa, Lacerda, Marcus Vinícius Guimarães, Ferreira, Guilherme Motta Antunes, Saunier, Maria de Nazaré, Macedo, Marielle Machado, Cristo, Denise de Almeida, Alves, Marla Jalene, Jackisch-Matsuura, Ani Beatriz, Ferreira, Cristina Motta
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 20-05-2020 BioMed Central BMC
Subjects:	Abdomen Aged Analysis Antibiotics Blood diseases Brazil C. neorformans Case Report Chemotherapy Cryptococcosis Cryptococcosis - diagnosis Cryptococcosis - drug therapy Cryptococcosis - genetics Cryptococcosis - microbiology Cryptococcus neoformans Cryptococcus neoformans - classification Cryptococcus neoformans - drug effects Cryptococcus neoformans - isolation & purification Deoxyribonucleic acid DNA Epidemiology Fatal Outcome Fungal infections Fungi Fungicides Genomes Genomics Genotypes Geographical distribution Haplotypes Humans Immunocompromised hosts Laboratories Lymphatic system Lymphoma Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - microbiology Medical research Medicine, Experimental Meningitis Microbial Sensitivity Tests MLST Molecular Epidemiology Multilocus Sequence Typing Mycological Typing Techniques Non-Hodgkin disease Non-Hodgkin's lymphoma Non-Hodgkin's lymphomas Patients Phylogenetics Phylogeny Polymerase Chain Reaction ST623 Thrombosis Tuberculosis Brazil C. neorformans Phylogeny MLST Non-Hodgkin disease ST623
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Summary:	Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization. This study described a case report, molecular epidemiology, the phylogenetic relationship, along with antifungal susceptibility test of a new ST 623 of C. neoformans isolated in a patient with non-Hodgkin's Lymphoma, from Manaus, Brazil. The new C. neoformans was susceptible to all antifungal drugs tested. Our results showed that ST623 new clone has no evident evolutionary proximity to any other ST of the VNI subtype group identified in Brazil. In the context of phylogenetic analysis, this new genotype belongs to VNI subtype, and subsequencing complete genome studies are necessary to better understand the phylogenetic relationships amongst STs in this group.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1476-0711 1476-0711
DOI:	10.1186/s12941-020-00361-3