Search Results - "Macdonald, T T"

Immunity, Inflammation, and Allergy in the Gut by MacDonald, Thomas T, Monteleone, Giovanni

“…The gut immune system has the challenge of responding to pathogens while remaining relatively unresponsive to food antigens and the commensal microflora. In…”
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PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation by Tricco, Andrea C, Lillie, Erin, Zarin, Wasifa, O'Brien, Kelly K, Colquhoun, Heather, Levac, Danielle, Moher, David, Peters, Micah D J, Horsley, Tanya, Weeks, Laura, Hempel, Susanne, Akl, Elie A, Chang, Christine, McGowan, Jessie, Stewart, Lesley, Hartling, Lisa, Aldcroft, Adrian, Wilson, Michael G, Garritty, Chantelle, Lewin, Simon, Godfrey, Christina M, Macdonald, Marilyn T, Langlois, Etienne V, Soares-Weiser, Karla, Moriarty, Jo, Clifford, Tammy, Tunçalp, Özge, Straus, Sharon E

“…Scoping reviews, a type of knowledge synthesis, follow a systematic approach to map evidence on a topic and identify main concepts, theories, sources, and…”
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Can probiotics modulate human disease by impacting intestinal barrier function? by Bron, Peter A., Kleerebezem, Michiel, Brummer, Robert-Jan, Cani, Patrice D., Mercenier, Annick, MacDonald, Thomas T., Garcia-Ródenas, Clara L., Wells, Jerry M.

“…Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining…”
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Homeostasis of the gut barrier and potential biomarkers by Wells, Jerry M, Brummer, Robert J, Derrien, Muriel, MacDonald, Thomas T, Troost, Freddy, Cani, Patrice D, Theodorou, Vassilia, Dekker, Jan, Méheust, Agnes, de Vos, Willem M, Mercenier, Annick, Nauta, Arjen, Garcia-Rodenas, Clara L

“…The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the…”
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Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth by De Simone, V, Franzè, E, Ronchetti, G, Colantoni, A, Fantini, M C, Di Fusco, D, Sica, G S, Sileri, P, MacDonald, T T, Pallone, F, Monteleone, G, Stolfi, C

“…Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells. The exact contribution of each immune cell subset and…”
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Regulation of Homeostasis and Inflammation in the Intestine by MacDonald, Thomas T, Monteleone, Ivan, Fantini, Massimo Claudio, Monteleone, Giovanni

“…The gastrointestinal tract is the largest immune interface with the environment. Exposure to large numbers of dietary and microbial antigens requires complex…”
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Rapid acquisition and model-based analysis of cell-free transcription–translation reactions from nonmodel bacteria by Moore, Simon J., MacDonald, James T., Wienecke, Sarah, Ishwarbhai, Alka, Tsipa, Argyro, Aw, Rochelle, Kylilis, Nicolas, Bell, David J., McClymont, David W., Jensen, Kirsten, Polizzi, Karen M., Biedendieck, Rebekka, Freemont, Paul S.

“…Native cell-free transcription–translation systems offer a rapid route to characterize the regulatory elements (promoters, transcription factors) for gene…”
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The IL-33/ST2 axis: Role in health and disease by De la Fuente, Marjorie, MacDonald, Thomas T, Hermoso, Marcela A

“…Highlights • Interleukin-33 (IL-33), is a member of the IL-1 cytokine family. • ST2L membrane-anchored receptor is activated by IL-33. • The soluble variant…”
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Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease by Rovedatti, L, Kudo, T, Biancheri, P, Sarra, M, Knowles, C H, Rampton, D S, Corazza, G R, Monteleone, G, Di Sabatino, A, Macdonald, T T

“…Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in…”
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Effect of ibuprofen on cardioprotective effect of aspirin by MacDonald, TM, Wei, L

“…Treatment with ibuprofen might limit the cardioprotective effects of aspirin. We aimed to assess whether patients with known cardiovascular disease who take…”
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Incidence and prevalence of multiple sclerosis in the UK 1990–2010: a descriptive study in the General Practice Research Database by Mackenzie, I S, Morant, S V, Bloomfield, G A, MacDonald, T M, O'Riordan, J

“…Objectives To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over…”
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Recent advances in gut immunology by Powell, N., MacDonald, T. T.

“…Summary In recent years, there have been significant advances in our understanding of the mucosal immune system. In addition to unravelling some of the…”
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Development of a Bacillus subtilis cell-free transcription-translation system for prototyping regulatory elements by Kelwick, Richard, Webb, Alexander J., MacDonald, James T., Freemont, Paul S.

“…Cell-free transcription-translation systems were originally applied towards in vitro protein production. More recently, synthetic biology is enabling these…”
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The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells by Powell, Nick, Walker, Alan W., Stolarczyk, Emilie, Canavan, James B., Gökmen, M. Refik, Marks, Ellen, Jackson, Ian, Hashim, Ahmed, Curtis, Michael A., Jenner, Richard G., Howard, Jane K., Parkhill, Julian, MacDonald, Thomas T., Lord, Graham M.

“…Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A…”
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Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut by Caruso, R, Marafini, I, Franzè, E, Stolfi, C, Zorzi, F, Monteleone, I, Caprioli, F, Colantoni, A, Sarra, M, Sedda, S, Biancone, L, Sileri, P, Sica, G S, MacDonald, T T, Pallone, F, Monteleone, G

“…In inflammatory bowel disease (IBD), tissue damage is driven by an excessive immune response, poorly controlled by counter-regulatory mechanisms. SIRT1, a…”
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Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21 by Monteleone, G, Caruso, R, Fina, D, Peluso, I, Gioia, V, Stolfi, C, Fantini, M C, Caprioli, F, Tersigni, R, Alessandroni, L, MacDonald, T T, Pallone, F

“…Background: T cell-mediated immunity plays a central part in the pathogenesis of tissue damage in inflammatory bowel disease (IBD). The mechanism by which T…”
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Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation by Zhang, Xinjun, Abreu, Jose Garcia, Yokota, Chika, MacDonald, Bryan T., Singh, Sasha, Coburn, Karla Loureiro Almeida, Cheong, Seong-Moon, Zhang, Mingzi M., Ye, Qi-Zhuang, Hang, Howard C., Steen, Hanno, He, Xi

“…Secreted Wnt morphogens are signaling molecules essential for embryogenesis, pathogenesis, and regeneration and require distinct modifications for secretion,…”
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Measurement of the neutron lifetime using a magneto-gravitational trap and in situ detection by Pattie, Jr, R W, Callahan, N B, Cude-Woods, C, Adamek, E R, Broussard, L J, Clayton, S M, Currie, S A, Dees, E B, Ding, X, Engel, E M, Fellers, D E, Fox, W, Geltenbort, P, Hickerson, K P, Hoffbauer, M A, Holley, A T, Komives, A, Liu, C-Y, MacDonald, S W T, Makela, M, Morris, C L, Ortiz, J D, Ramsey, J, Salvat, D J, Saunders, A, Seestrom, S J, Sharapov, E I, Sjue, S K, Tang, Z, Vanderwerp, J, Vogelaar, B, Walstrom, P L, Wang, Z, Wei, W, Weaver, H L, Wexler, J W, Womack, T L, Young, A R, Zeck, B A

“…The precise value of the mean neutron lifetime, τ , plays an important role in nuclear and particle physics and cosmology. It is used to predict the ratio of…”
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Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy by Pavlidis, Polychronis, Tsakmaki, Anastasia, Pantazi, Eirini, Li, Katherine, Cozzetto, Domenico, Digby- Bell, Jonathan, Yang, Feifei, Lo, Jonathan W., Alberts, Elena, Sa, Ana Caroline Costa, Niazi, Umar, Friedman, Joshua, Long, Anna K., Ding, Yuchun, Carey, Christopher D., Lamb, Christopher, Saqi, Mansoor, Madgwick, Matthew, Gul, Leila, Treveil, Agatha, Korcsmaros, Tamas, Macdonald, Thomas T., Lord, Graham M., Bewick, Gavin, Powell, Nick

“…The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial. Here, we map the transcriptional landscape regulated by IL-22…”
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Treatment of high-grade glioma in children and adolescents by MacDonald, T. J., Aguilera, D., Kramm, C. M.

“…Pediatric high-grade gliomas (HGGs)-including glioblastoma multiforme, anaplastic astrocytoma, and diffuse intrinsic pontine glioma-are difficult to treat and…”
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