Search Results - "Macdonald, R L"

Mechanisms of microthrombi formation after experimental subarachnoid hemorrhage by Sabri, M, Ai, J, Lakovic, K, D’abbondanza, J, Ilodigwe, D, Macdonald, R.L

“…Highlights ► Mice have constricted brain arterioles 2 days after subarachnoid hemorrhage. ► Mice have microthrombi in brain arterioles 2 days after…”
Get full text

Learning deficits after experimental subarachnoid hemorrhage in rats by Jeon, H, Ai, J, Sabri, M, Tariq, A, Macdonald, R.L

“…Abstract About 50% of subarachnoid hemorrhage (SAH) survivors have cognitive or neurobehavioral dysfunction. The mechanisms are not known. This study…”
Get full text

Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism by Delahanty, R J, Kang, J Q, Brune, C W, Kistner, E O, Courchesne, E, Cox, N J, Cook, E H, Macdonald, R L, Sutcliffe, J S

“…Maternal 15q11-q13 duplication is the most common copy number variant in autism, accounting for ∼1–3% of cases. The 15q11-q13 region is subject to epigenetic…”
Get full text

A novel GABRG2 mutation associated with febrile seizures by AUDENAERT, D, SCHWARTZ, E, DE JONGHE, P, CLAEYS, K. G, CLAES, L, DEPREZ, L, SUIS, A, VAN DYCK, T, LAGAE, L, VAN BROECKHOVEN, C, MACDONALD, R. L

“…Mutations in the gene encoding the gamma2 subunit of the gamma-aminobutyric acid type A receptor (GABRG2) have been reported to cause childhood absence…”
Get full text

Multiplexing strategies for monolithic crystal PET detector modules by Pierce, L A, Hunter, W C J, Haynor, D R, MacDonald, L R, Kinahan, P E, Miyaoka, R S

“…To reduce the number of output channels and associated cost in PET detectors, strategies to multiplex the signal channels have been investigated by several…”
Get more information

A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors by TORRES, I. J, MUNDT, A. J, SWEENEY, P. J, LLANES-MACY, S, DUNAWAY, L, CASTILLO, M, MACDONALD, R. L

“…To investigate longitudinal cognitive functioning in patients with brain tumor treated with modern highly conformal fractionated partial brain radiation…”
Get full text

Loss of long-term potentiation in the hippocampus after experimental subarachnoid hemorrhage in rats by Tariq, A, Ai, J, Chen, G, Sabri, M, Jeon, H, Shang, X, Macdonald, R.L

“…Abstract Survivors of aneurysmal subarachnoid hemorrhage (SAH) often suffer from cognitive impairment such as memory loss. However, the underlying mechanisms…”
Get full text

Effective count rates for PET scanners with reduced and extended axial field of view by MacDonald, L R, Harrison, R L, Alessio, A M, Hunter, W C J, Lewellen, T K, Kinahan, P E

“…We investigated the relationship between noise equivalent count (NEC) and axial field of view (AFOV) for PET scanners with AFOVs ranging from one-half to twice…”
Get more information

Measured count-rate performance of the Discovery STE PET/CT scanner in 2D, 3D and partial collimation acquisition modes by Macdonald, L R, Schmitz, R E, Alessio, A M, Wollenweber, S D, Stearns, C W, Ganin, A, Harrison, R L, Lewellen, T K, Kinahan, P E

“…We measured count rates and scatter fraction on the Discovery STE PET/CT scanner in conventional 2D and 3D acquisition modes, and in a partial collimation mode…”
Get more information

Management of aneurysmal subarachnoid hemorrhage by Etminan, N, Macdonald, R L

“…Spontaneous subarachnoid hemorrhage (SAH) affects people with a mean age of 55 years. Although there are about 9/100 000 cases per year worldwide, the young…”
Get more information

Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms by Saxena, N C, Macdonald, R L

“…Analysis of the composition of cerebellar gamma-aminobutyric acidA (GABAA) receptors (GABARs) with in situ hybridization of GABAR subunit subtype mRNAs [J…”
Get more information

Neurosteroid regulation of GABAA receptor single-channel kinetic properties of mouse spinal cord neurons in culture by Twyman, R E, Macdonald, R L

“…1. Single-channel kinetics of steroid enhancement of single gamma-aminobutyric acidA (GABA) receptor currents obtained from somata of mouse spinal cord…”
Get full text

Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture by Rogers, C J, Twyman, R E, Macdonald, R L

“…1. The effects of the benzodiazepine receptor agonist, diazepam (DZ), and the inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate…”
Get full text

Assembly of GABAA receptor subunits: role of the delta subunit by Saxena, NC, Macdonald, RL

“…GABAA receptor channels (GABARs) composed of different combinations of rat alpha 1, beta 1, gamma 2L, and delta subunits were expressed transiently in mouse…”
Get full text

Role of angiography following aneurysm surgery by MACDONALD, R. L, WALLACE, C, KESTLE, J. R. W

“…The postoperative angiograms in 66 patients who underwent craniotomy for clipping of 78 cerebral aneurysms were reviewed. Indications for urgent postoperative…”
Get full text

Evaluation of event position reconstruction in monolithic crystals that are optically coupled by Morrocchi, M, Hunter, W C J, Del Guerra, A, Lewellen, T K, Kinahan, P E, MacDonald, L R, Bisogni, M G, Miyaoka, R S

“…A PET detector featuring a pseudo-monolithic crystal is being developed as a more cost-effective alternative to a full monolithic crystal PET detector. This…”
Get more information

Role of von Willebrand factor and ADAMTS‐13 in early brain injury after experimental subarachnoid hemorrhage by Wan, H., Wang, Y., Ai, J., Brathwaite, S., Ni, H., Macdonald, R.L., Hol, E.M., Meijers, J.C.M., Vergouwen, M.D.I.

“…Essentials von Willebrand Factor (VWF) and ADAMTS13 may affect early injury after subarachnoid hemorrhage (SAH). Early brain injury was assessed in VWF−/−,…”
Get full text

Prospective Multicenter Study of Changes in MTT after Aneurysmal SAH and Relationship to Delayed Cerebral Ischemia in Patients with Good- and Poor-Grade Admission Status by Murphy, A, Lee, T-Y, Marotta, T R, Spears, J, Macdonald, R L, Aviv, R I, Baker, A, Bharatha, A

“…Patients with aneurysmal SAH and good clinical status at admission are considered at a lower risk for delayed cerebral ischemia. Prolonged MTT may be…”
Get full text

A review of hemoglobin and the pathogenesis of cerebral vasospasm by LOCH MACDONALD, R, WEIR, B. K. A

“…We believe that current experimental and clinical evidence can be most satisfactorily interpreted by assuming that oxyhemoglobin is the cause of cerebral…”
Get full text

Pathophysiology and molecular genetics of vasospasm by Macdonald, R L

Get more information