Search Results - "Macdonald, R H"

Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus by Wilson, A, MacDonald, H R, Radtke, F

“…We have recently reported that Notch 1, a member of the Notch multigene family, is essential for the development of murine T cells. Using a mouse model in…”
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The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and Mouse by MacDonald, Heather R., Wevrick, Rachel

“…Human chromosome 15q11-q13 contains genes that are imprinted and expressed from only one parental allele. Prader-Willi syndrome (PWS) is due to the loss of…”
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Selective Bystander Proliferation of Memory CD4+ and CD8+ T Cells Upon NK T or T Cell Activation by Eberl, Gerard, Brawand, Pierre, MacDonald, H. Robson

“…Ag-experienced or memory T cells have increased reactivity to recall Ag, and can be distinguished from naive T cells by altered expression of surface markers…”
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Two waves of recombinase gene expression in developing thymocytes by WILSON, A, HELD, W, MACDONALD, H. R

“…During T cell development in the thymus, T cell receptor (TCR) alpha, beta, gamma, and delta genes are rearranged and expressed. TCR rearrangement strictly…”
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An HMG-box-containing T-cell factor required for thymocyte differentiation by Verbeek, Sjef, Izon, David, Hofhuis, Frans, Robanus-Maandag, Els, te Riele, Hein, Watering, Marc van de, Oosterwegel, Mariette, Wilson, Anne, Robson MacDonald, H, Clevers, Hans

“…Two candidate genes for controlling thymocyte differentiation, T-cell factor-1 (Tcf-1) and lymphoid enhancer-binding factor (Lef-1), encode closely related…”
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Vacuolar H⁺-Translocating Pyrophosphatase Is Induced by Anoxia or Chilling in Seedlings of Rice by George D. Carystinos, Heather R. Mac Donald, Monroy, Antonio F., Dhindsa, Rajinder S., Poole, Ronald J.

“…The present study was undertaken to determine whether vacuolar H+-pyrophosphatase (V-PPase) might replace vacuolar H+-ATPase under energy stress due to anoxia…”
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Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death) by Peitsch, M.C., Polzar, B., Stephan, H., Crompton, T., MacDonald, H.R., Mannherz, H.G., Tschopp, J.

“…Cell death by apoptosis occurs in a wide range of physiological events including repertoire selection of lymphocytes and during immune responses in vivo. A…”
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Granzyme A is an interleukin 1 beta-converting enzyme by Irmler, M, Hertig, S, MacDonald, H R, Sadoul, R, Becherer, J D, Proudfoot, A, Solari, R, Tschopp, J

“…Apoptosis is critically dependent on the presence of the ced-3 gene in Caenorhabditis elegans, which encodes a protein homologous to the mammalian interleukin…”
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Biased V beta usage in immature thymocytes is independent of DJ beta proximity and pT alpha pairing by Wilson, A, Maréchal, C, MacDonald, H R

“…During thymus development, the TCR beta locus rearranges before the TCR alpha locus. Pairing of productively rearranged TCR beta-chains with an invariant pT…”
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Notch regulation of lymphocyte development and function by Radtke, Freddy, Wilson, Anne, Mancini, Stephane J C, MacDonald, H Robson

“…Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch…”
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DL4‐mediated Notch signaling is required for the development of fetal αβ and γδ T cells by Ferrero, Isabel, Koch, Ute, Claudinot, Stephanie, Favre, Stéphanie, Radtke, Freddy, Luther, Sanjiv A., MacDonald, H. R.

“…T‐cell development depends upon interactions between thymocytes and thymic epithelial cells (TECs). The engagement of delta‐like 4 (DL4) on TECs by Notch1…”
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A urine inhibitor of interleukin 1 activity that blocks ligand binding by Seckinger, P, Lowenthal, JW, Williamson, K, Dayer, JM, MacDonald, HR

“…Urine from febrile patients was found to contain a novel inhibitor of interleukin 1 (IL-1) bioactivity that blocked the specific binding of radioiodinated IL-1…”
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Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1 by Radtke, Freddy, Wilson, Anne, Stark, Gerlinde, Bauer, Michelle, van Meerwijk, Joost, MacDonald, H.Robson, Aguet, Michel

“…Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion…”
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Beta-catenin is dispensable for hematopoiesis and lymphopoiesis by Cobas, Monica, Wilson, Anne, Ernst, Bettina, Mancini, Stéphane J C, MacDonald, H Robson, Kemler, Rolf, Radtke, Freddy

“…Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the…”
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Programmed death of autoreactive thymocytes by MacDonald, H. Robson, Lees, Rosemary K

“…T lymphocytes bearing high-affinity T-cell receptors (TCR) for self-antigens are clonally deleted during thymus development. Several recent studies have…”
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Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells by Eberl, Gérard, MacDonald, H. Robson

“…NK T cells produce cytokines when their semi‐invariant TCR engages glycolipids associated with CD1d. The physiological consequences of NKT cell activation…”
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MHC-II-Independent CD4+ T Cells Induce Colitis in Immunodeficient RAG-/- Hosts by Trobonjaca, Zlatko, Leithauser, Frank, Moller, Peter, Bluethmann, Horst, Koezuka, Yasuhiko, MacDonald, H. Robson, Reimann, Jorg

“…CD4(+) alpha beta T cells from either normal C57BL/6 (B6) or MHC-II-deficient (A alpha(-/-) or A beta(-/-)) B6 donor mice engrafted into congenic…”
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The Cellular Basis of T-Cell Memory by Cerottini, J C, MacDonald, H R

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NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function by MacDonald, H R

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Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus by HELD, W, SHAKHOV, A. N, IZUI, S, WAANDERS, G. A, SCARPELLINO, L, MACDONALD, H. R, ACHA-ORBEA, H

“…Superantigens are defined by their ability to stimulate a large fraction of T cells via interaction with the T cell receptor (TCR) V beta domain. Endogenous…”
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