Search Results - "Macdonald, Lynn E."

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes by Macdonald, Lynn E., Karow, Margaret, Stevens, Sean, Auerbach, Wojtek, Poueymirou, William T., Yasenchak, Jason, Frendewey, David, Valenzuela, David M., Giallourakis, Cosmas C., Alt, Frederick W., Yancopoulos, George D., Murphy, Andrew J.

“…Genetic humanization, which involves replacing mouse genes with their human counterparts, can create powerful animal models for the study of human genes and…”
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Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice by Murphy, Andrew J., Macdonald, Lynn E., Stevens, Sean, Karow, Margaret, Dore, Anthony T., Pobursky, Kevin, Huang, Tammy T., Poueymirou, William T., Esau, Lakeisha, Meola, Melissa, Mikulka, Warren, Krueger, Pamela, Fairhurst, Jeanette, Valenzuela, David M., Papadopoulos, Nicholas, Yancopoulos, George D.

“…Mice genetically engineered to be humanized for their Ig genes allow for human antibody responses within a mouse background (HumAb mice), providing a valuable…”
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Humanized mouse model supports development, function, and tissue residency of human natural killer cells by Herndler-Brandstetter, Dietmar, Shan, Liang, Yao, Yi, Stecher, Carmen, Plajer, Valerie, Lietzenmayer, Melanie, Strowig, Till, de Zoete, Marcel R., Palm, Noah W., Chen, Jie, Blish, Catherine A., Frleta, Davor, Gurer, Cagan, Macdonald, Lynn E., Murphy, Andrew J., Yancopoulos, George D., Montgomery, Ruth R., Flavell, Richard A.

“…Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of…”
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Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice by Gillis, Caitlin M., BSci, Jönsson, Friederike, PhD, Mancardi, David A., PhD, Tu, Naxin, PhD, Beutier, Héloïse, PharmD, Van Rooijen, Nico, PhD, Macdonald, Lynn E., PhD, Murphy, Andrew J., PhD, Bruhns, Pierre, PhD

“…Background Anaphylaxis can proceed through distinct IgE- or IgG-dependent pathways, which have been investigated in various mouse models. We developed a novel…”
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An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence by Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George

“…The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human…”
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Pharmacological inhibition of NPY receptors illustrates dissociable features of experimental colitis in the mouse DSS model: Implications for preclinical evaluation of efficacy in an inflammatory bowel disease model by Ruiz, Henry H, Becker, Stephanie, Bai, Yu, Cortes-Burgos, Luz A, Eckersdorff, Melissa M, Macdonald, Lynn E, Croll, Susan D

“…Administration of dextran sodium sulfate (DSS) to rodents at varying concentrations and exposure times is commonly used to model human inflammatory bowel…”
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Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor by Anderson, Keith D, Pan, Li, Yang, Xiao-man, Hughes, Virginia C, Walls, Johnathon R, Dominguez, Melissa G, Simmons, Mary V, Burfeind, Patricia, Xue, Yingzi, Wei, Yi, Macdonald, Lynn E, Thurston, Gavin, Daly, Christopher, Lin, Hsin Chieh, Economides, Aris N, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gale, Nicholas W

“…The vasculature of the CNS is structurally and functionally distinct from that of other organ systems and is particularly prone to developmental abnormalities…”
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Evaluation of the capacities of mouse TCR profiling from short read RNA-seq data by Bai, Yu, Wang, David, Li, Wentian, Huang, Ying, Ye, Xuan, Waite, Janelle, Barry, Thomas, Edelmann, Kurt H, Levenkova, Natasha, Guo, Chunguang, Skokos, Dimitris, Wei, Yi, Macdonald, Lynn E, Fury, Wen

“…Profiling T cell receptor (TCR) repertoire via short read transcriptome sequencing (RNA-Seq) has a unique advantage of probing simultaneously TCRs and the…”
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Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence by Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model by Ye, Xuan, Waite, Janelle C., Dhanik, Ankur, Gupta, Namita, Zhong, Maggie, Adler, Christina, Malahias, Evangelia, Ni, Min, Wei, Yi, Gurer, Cagan, Zhang, Wen, Macdonald, Lynn E., Murphy, Andrew J., Sleeman, Matthew A., Skokos, Dimitris

“…Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor (TCR) clonality, tumor mutation burden…”
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AdRoit is an accurate and robust method to infer complex transcriptome composition by Yang, Tao, Alessandri-Haber, Nicole, Fury, Wen, Schaner, Michael, Breese, Robert, LaCroix-Fralish, Michael, Kim, Jinrang, Adler, Christina, Macdonald, Lynn E., Atwal, Gurinder S., Bai, Yu

“…Bulk RNA sequencing provides the opportunity to understand biology at the whole transcriptome level without the prohibitive cost of single cell profiling…”
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A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant by French, Shauna L., Thalmann, Claudia, Bray, Paul F., Macdonald, Lynn E., Murphy, Andrew J., Sleeman, Mark W., Hamilton, Justin R.

“…Thrombin activates human platelets via 2 protease-activated receptors (PARs), PAR1 and PAR4, both of which are antithrombotic drug targets: a PAR1 inhibitor is…”
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Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain by Somersan-Karakaya, Selin, Turner, Kenneth C., Cortes-Burgos, Luz, Miller, Jutta, LaCroix-Fralish, Michael, Logovinsky, Veronika, Patel, Yamini, Torres, Richard, Ganguly, Samit, Breazna, Aurora, DeVeaux, Michelle, Bhore, Rafia, Gao, Min, Delfino, Frank J., Rafique, Ashique, Fairhurst, Jeanette L., Hunt, Charleen, Babb, Robert, Badithe, Ashok, Poueymirou, William T., Surowitz, Ronald, Rottey, Sylvie, Murphy, Andrew J., Harari, Olivier, Macdonald, Lynn E., Croll, Susan D.

“…•Anti-GFRα3 antibody attenuated allodynia and thermal hyperalgesia in mouse models.•In humans, safety of single doses of up to 3000 mg was comparable to…”
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Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination by Giallourakis, Cosmas C., Franklin, Andrew, Guo, Chunguang, Cheng, Hwei-Ling, Yoon, Hye Suk, Gallagher, Michael, Perlot, Thomas, Andzelm, Milena, Murphy, Andrew J., Macdonald, Lynn E., Yancopoulos, George D., Alt, Frederick W.

“…Ig and T-cell receptor (TCR) variable-region gene exons are assembled from component variable (V), diversity (D) and joining (J) gene segments during early B…”
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Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity by Zamolodchikov, Daria, Duffield, Michael, Macdonald, Lynn E., Alessandri‐Haber, Nicole

“…Increased activation of the contact system protein high molecular weight kininogen (HK) has been shown in plasma and cerebrospinal fluid of Alzheimer's disease…”
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Sustained Increases in Immune Transcripts and Immune Cell Trafficking During the Recovery of Experimental Brain Ischemia by Fury, Wen, Park, Keun Woo, Wu, Zhuhao, Kim, Eunhee, Woo, Moon-sook, Bai, Yu, Macdonald, Lynn E., Croll, Susan D., Cho, Sunghee

“…BACKGROUND AND PURPOSE:Stroke is a major cause of chronic neurological disability. There is considerable interest in understanding how acute transcriptome…”
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The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors by Balbino, Bianca, Herviou, Pauline, Godon, Ophélie, Stackowicz, Julien, Goff, Odile Richard-Le, Iannascoli, Bruno, Sterlin, Delphine, Brûlé, Sébastien, Millot, Gael A, Harris, Faith M, Voronina, Vera A, Nadeau, Kari C, Macdonald, Lynn E, Murphy, Andrew J, Bruhns, Pierre, Reber, Laurent L

“…Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of omalizumab is…”
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A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain by Zamolodchikov, Daria, Bai, Yu, Tang, Yajun, McWhirter, John R., Macdonald, Lynn E., Alessandri-Haber, Nicole

“…Coagulation factor XII (FXII) is synthesized in the liver and secreted into the circulation, where it initiates the contact activation system. Although…”
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Disruption of nuclear envelope integrity as a possible initiating event in tauopathies by Prissette, Marine, Fury, Wen, Koss, Matthew, Racioppi, Claudia, Fedorova, Daria, Dragileva, Ella, Clarke, Georgia, Pohl, Taylor, Dugan, John, Ahrens, Diana, Chiu, Joyce, Hunt, Charleen, Siao, Chia-Jen, Young, Tara, Bhowmick, Arijit, Rogulin, Vitaliy, Desclaux, Mathieu, Hayden, Eric Y., Podgorski, Michael, Gao, Min, Macdonald, Lynn E., Frendewey, David, Yancopoulos, George D., Zambrowicz, Brian

“…The microtubule-associated protein tau is an abundant component of neurons of the central nervous system. In Alzheimer’s disease and other neurodegenerative…”
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IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice by Todorova, Biliana, Godon, Ophélie, Conde, Eva, Gillis, Caitlin M., Iannascoli, Bruno, Richard-Le Goff, Odile, Fiole, Daniel, Roumenina, Lubka T., Leusen, Jeanette H. W., Murphy, Andrew J., Macdonald, Lynn E., Reber, Laurent L., Jönsson, Friederike, Bruhns, Pierre

“…Abstract Mouse models of active systemic anaphylaxis rely predominantly on IgG Abs forming IgG–allergen immune complexes that induce IgG receptor–expressing…”
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