Search Results - "Macdonald, Lynn"

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes by Macdonald, Lynn E., Karow, Margaret, Stevens, Sean, Auerbach, Wojtek, Poueymirou, William T., Yasenchak, Jason, Frendewey, David, Valenzuela, David M., Giallourakis, Cosmas C., Alt, Frederick W., Yancopoulos, George D., Murphy, Andrew J.

“…Genetic humanization, which involves replacing mouse genes with their human counterparts, can create powerful animal models for the study of human genes and…”
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Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice by Murphy, Andrew J., Macdonald, Lynn E., Stevens, Sean, Karow, Margaret, Dore, Anthony T., Pobursky, Kevin, Huang, Tammy T., Poueymirou, William T., Esau, Lakeisha, Meola, Melissa, Mikulka, Warren, Krueger, Pamela, Fairhurst, Jeanette, Valenzuela, David M., Papadopoulos, Nicholas, Yancopoulos, George D.

“…Mice genetically engineered to be humanized for their Ig genes allow for human antibody responses within a mouse background (HumAb mice), providing a valuable…”
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Humanized mouse model supports development, function, and tissue residency of human natural killer cells by Herndler-Brandstetter, Dietmar, Shan, Liang, Yao, Yi, Stecher, Carmen, Plajer, Valerie, Lietzenmayer, Melanie, Strowig, Till, de Zoete, Marcel R., Palm, Noah W., Chen, Jie, Blish, Catherine A., Frleta, Davor, Gurer, Cagan, Macdonald, Lynn E., Murphy, Andrew J., Yancopoulos, George D., Montgomery, Ruth R., Flavell, Richard A.

“…Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of…”
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Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity by Zamolodchikov, Daria, Duffield, Michael, Macdonald, Lynn E., Alessandri‐Haber, Nicole

“…Increased activation of the contact system protein high molecular weight kininogen (HK) has been shown in plasma and cerebrospinal fluid of Alzheimer's disease…”
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Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice by Gillis, Caitlin M., BSci, Jönsson, Friederike, PhD, Mancardi, David A., PhD, Tu, Naxin, PhD, Beutier, Héloïse, PharmD, Van Rooijen, Nico, PhD, Macdonald, Lynn E., PhD, Murphy, Andrew J., PhD, Bruhns, Pierre, PhD

“…Background Anaphylaxis can proceed through distinct IgE- or IgG-dependent pathways, which have been investigated in various mouse models. We developed a novel…”
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Pharmacological inhibition of NPY receptors illustrates dissociable features of experimental colitis in the mouse DSS model: Implications for preclinical evaluation of efficacy in an inflammatory bowel disease model by Ruiz, Henry H, Becker, Stephanie, Bai, Yu, Cortes-Burgos, Luz A, Eckersdorff, Melissa M, Macdonald, Lynn E, Croll, Susan D

“…Administration of dextran sodium sulfate (DSS) to rodents at varying concentrations and exposure times is commonly used to model human inflammatory bowel…”
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An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence by Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George

“…The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human…”
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IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice by Todorova, Biliana, Godon, Ophélie, Conde, Eva, Gillis, Caitlin M., Iannascoli, Bruno, Richard-Le Goff, Odile, Fiole, Daniel, Roumenina, Lubka T., Leusen, Jeanette H. W., Murphy, Andrew J., Macdonald, Lynn E., Reber, Laurent L., Jönsson, Friederike, Bruhns, Pierre

“…Abstract Mouse models of active systemic anaphylaxis rely predominantly on IgG Abs forming IgG–allergen immune complexes that induce IgG receptor–expressing…”
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Sustained Increases in Immune Transcripts and Immune Cell Trafficking During the Recovery of Experimental Brain Ischemia by Fury, Wen, Park, Keun Woo, Wu, Zhuhao, Kim, Eunhee, Woo, Moon-sook, Bai, Yu, Macdonald, Lynn E., Croll, Susan D., Cho, Sunghee

“…BACKGROUND AND PURPOSE:Stroke is a major cause of chronic neurological disability. There is considerable interest in understanding how acute transcriptome…”
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The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors by Balbino, Bianca, Herviou, Pauline, Godon, Ophélie, Stackowicz, Julien, Goff, Odile Richard-Le, Iannascoli, Bruno, Sterlin, Delphine, Brûlé, Sébastien, Millot, Gael A, Harris, Faith M, Voronina, Vera A, Nadeau, Kari C, Macdonald, Lynn E, Murphy, Andrew J, Bruhns, Pierre, Reber, Laurent L

“…Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of omalizumab is…”
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Evaluation of the capacities of mouse TCR profiling from short read RNA-seq data by Bai, Yu, Wang, David, Li, Wentian, Huang, Ying, Ye, Xuan, Waite, Janelle, Barry, Thomas, Edelmann, Kurt H, Levenkova, Natasha, Guo, Chunguang, Skokos, Dimitris, Wei, Yi, Macdonald, Lynn E, Fury, Wen

“…Profiling T cell receptor (TCR) repertoire via short read transcriptome sequencing (RNA-Seq) has a unique advantage of probing simultaneously TCRs and the…”
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A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain by Zamolodchikov, Daria, Bai, Yu, Tang, Yajun, McWhirter, John R., Macdonald, Lynn E., Alessandri-Haber, Nicole

“…Coagulation factor XII (FXII) is synthesized in the liver and secreted into the circulation, where it initiates the contact activation system. Although…”
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Disruption of nuclear envelope integrity as a possible initiating event in tauopathies by Prissette, Marine, Fury, Wen, Koss, Matthew, Racioppi, Claudia, Fedorova, Daria, Dragileva, Ella, Clarke, Georgia, Pohl, Taylor, Dugan, John, Ahrens, Diana, Chiu, Joyce, Hunt, Charleen, Siao, Chia-Jen, Young, Tara, Bhowmick, Arijit, Rogulin, Vitaliy, Desclaux, Mathieu, Hayden, Eric Y., Podgorski, Michael, Gao, Min, Macdonald, Lynn E., Frendewey, David, Yancopoulos, George D., Zambrowicz, Brian

“…The microtubule-associated protein tau is an abundant component of neurons of the central nervous system. In Alzheimer’s disease and other neurodegenerative…”
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Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor by Anderson, Keith D, Pan, Li, Yang, Xiao-man, Hughes, Virginia C, Walls, Johnathon R, Dominguez, Melissa G, Simmons, Mary V, Burfeind, Patricia, Xue, Yingzi, Wei, Yi, Macdonald, Lynn E, Thurston, Gavin, Daly, Christopher, Lin, Hsin Chieh, Economides, Aris N, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gale, Nicholas W

“…The vasculature of the CNS is structurally and functionally distinct from that of other organ systems and is particularly prone to developmental abnormalities…”
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Insight and Perspective From the Past by Foley, John T., MacDonald, Lynn C., Pratt, Erica

“…In exploring older physical education textbooks there is a renewed appreciation for past leaders and their foresight in critical areas of our profession. While…”
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A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity by Zhang, Wen, Hawkins, Peter G, He, Jing, Gupta, Namita T, Liu, Jinrui, Choonoo, Gabrielle, Jeong, Se W, Chen, Calvin R, Dhanik, Ankur, Dillon, Myles, Deering, Raquel, Macdonald, Lynn E, Thurston, Gavin, Atwal, Gurinder S

“…T cell receptor (TCR) antigen-specific recognition is essential for the adaptive immune system. However, building a TCR-antigen interaction map has been…”
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Unpacking the physical literacy concept for K-12 physical education：What should we expect the learner to master by Roetert, E. Paul, MacDonald, Lynn Couturier

“…The term “physical literacy” is gaining traction in many countries and institutions as a goal for physical education. This paper explores the concept of…”
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Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice by Gao, Jie, Ren, Shumei, Choonoo, Gabrielle, Chen, Guoying, Frleta, Davor, Zhong, Jun, Gupta, Namita, Sharma, Prachi, Oyejide, Adelekan, Atwal, Gurinder S., Macdonald, Lynn, Murphy, Andrew, Kuhnert, Frank

“…ABSTRACT Sezary syndrome (SS) is a rare, aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) that lacks adequate therapeutic options and…”
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Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct by Voronina, Vera A, Harris, Faith M, Schmahl, Jennifer, Galligan, Caryn, Oristian, Daniel, Zamfirova, Ralica, Gong, Guochun, Bai, Yu, Fury, Wen, Rajamani, Saathyaki, Walls, Johnathon R, Poueymirou, William T, Esau, Lakeisha, Gale, Nicholas W, Auerbach, Wojtek, Murphy, Andrew J, Macdonald, Lynn E

“…The Adisintegrin and metalloprotease domain-containing (ADAM) family of proteins is involved in cell adhesion, migration, proteolysis, and signaling. Many…”
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Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence by Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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