Search Results - "Maccari, Rosanna"

Targeting Aldose Reductase for the Treatment of Diabetes Complications and Inflammatory Diseases: New Insights and Future Directions by Maccari, Rosanna, Ottanà, Rosaria

“…Aldose reductase (AR) is an aldo–keto reductase that has been widely investigated as an enzyme crucially involved in the pathogenesis of chronic complications…”
Get full text

Can Allostery Be a Key Strategy for Targeting PTP1B in Drug Discovery? A Lesson from Trodusquemine by Maccari, Rosanna, Ottanà, Rosaria

“…Protein tyrosine phosphatase 1B (PTP1B) is an enzyme crucially implicated in aberrations of various signaling pathways that underlie the development of…”
Get full text

In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B by Ottanà, Rosaria, Paoli, Paolo, Cappiello, Mario, Nguyen, Trung Ngoc, Adornato, Ilenia, Del Corso, Antonella, Genovese, Massimo, Nesi, Ilaria, Moschini, Roberta, Naß, Alexandra, Wolber, Gerhard, Maccari, Rosanna

“…Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its…”
Get full text

In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors by Maccari, Rosanna, Corso, Antonella Del, Giglio, Marco, Moschini, Roberta, Mura, Umberto, Ottanà, Rosaria

“…2-Thioxo-4-thiazolidinone derivatives were evaluated as aldose reductase inhibitors (ARIs) and most of them exhibited good or excellent in vitro efficacy. Out…”
Get full text

In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I by Ottanà, Rosaria, Carotti, Stefania, Maccari, Rosanna, Landini, Ida, Chiricosta, Giuseppa, Caciagli, Barbara, Vigorita, Maria Gabriella, Mini, Enrico

“…The characterization of two cyclooxygenase isoforms (COX), the rate-limiting enzyme for the synthesis of prostaglandins (PGs) from arachidonic acid, has…”
Get full text

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives by Maccari, Rosanna, Ottanà, Rosaria, Ciurleo, Rosella, Rakowitz, Dietmar, Matuszczak, Barbara, Laggner, Christian, Langer, Thierry

“…In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously…”
Get full text

Identification of new non-carboxylic acid containing inhibitors of aldose reductase by Maccari, Rosanna, Ciurleo, Rosella, Giglio, Marco, Cappiello, Mario, Moschini, Roberta, Corso, Antonella Del, Mura, Umberto, Ottanà, Rosaria

“…New non-carboxylic acid containing 5-arylidene-2,4-thiazolidinedione derivatives have been identified as aldose reductase inhibitors active at low micromolar…”
Get full text

Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones by Maccari, Rosanna, Ottanà, Rosaria, Ciurleo, Rosella, Vigorita, Maria Gabriella, Rakowitz, Dietmar, Steindl, Theodora, Langer, Thierry

“…A number of 5-arylidene-2,4-thiazolidinediones containing a hydroxy or a carboxymethoxy group in their 5-benzylidene moiety have been synthesised and evaluated…”
Get full text

5-Arylidene-4-thiazolidinone derivatives active as antidegenerative agents on human chondrocyte cultures by Panico, Annamaria, Maccari, Rosanna, Cardile, Venera, Crasci, Lucia, Ronsisvalle, Simone, Ottanà, Rosaria

“…5-Arylidene-2-oxo-4-thiazolidinones and 2-phenylimino analogues were evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by…”
Get more information

In Vitro Antimycobacterial Activities of 2′-Monosubstituted Isonicotinohydrazides and Their Cyanoborane Adducts by MACCARI, Rosanna, OTTANA, Rosaria, MONFORTE, Francesca, VIGORITA, Maria Gabriella

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Modeling and biological evaluation of 3,3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor by Ottaná, Rosaria, Mazzon, Emanuela, Dugo, Laura, Monforte, Francesca, Maccari, Rosanna, Sautebin, Lidia, De Luca, Grazia, Vigorita, Maria Gabriella, Alcaro, Stefano, Ortuso, Francesco, Caputi, Achille P, Cuzzocrea, Salvatore

“…Within the series of chiral 3,3′-(1,2-ethanediyl)bis[2-arylthiazolidin-4-ones], the 3,4-dimethoxyphenyl substituted derivative was found in the primary…”
Get full text

Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives by Maccari, Rosanna, Ottanà, Rosaria

“…Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (gliflozins) represent the most recently approved class of oral antidiabetic drugs. SGLT-2 overexpression in…”
Get full text

Extending the investigation of 4-thiazolidinone derivatives as potential multi-target ligands of enzymes involved in diabetes mellitus and its long-term complications: A study with pancreatic α-amylase by Szabó, Kármen, Maccari, Rosanna, Ottanà, Rosaria, Gyémánt, Gyöngyi

“…Diabetes mellitus is a multifactorial disease, which is frequently complicated by the development of hyperglycaemia-induced chronic complications. The therapy…”
Get full text

An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications by Maccari, Rosanna, Del Corso, Antonella, Paoli, Paolo, Adornato, Ilenia, Lori, Giulia, Balestri, Francesco, Cappiello, Mario, Naß, Alexandra, Wolber, Gerhard, Ottanà, Rosaria

“…[Display omitted] •4-Thiazolidinones were synthesised and tested as dual AR/PTP1B inhibitors.•SAR, molecular docking and kinetic studies were carried out.•Two…”
Get full text

Protein-Tyrosine Phosphatase-1B Mediates Sleep Fragmentation-Induced Insulin Resistance and Visceral Adipose Tissue Inflammation in Mice by Gozal, David, Khalyfa, Abdelnaby, Qiao, Zhuanghong, Akbarpour, Mahzad, Maccari, Rosanna, Ottanà, Rosaria

“…Abstract Study Objectives Sleep fragmentation (SF) is highly prevalent and has emerged as an important contributing factor to obesity and metabolic syndrome…”
Get full text

Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors by Maccari, Rosanna, Wolber, Gerhard, Genovese, Massimo, Sardelli, Gemma, Talagayev, Valerij, Balestri, Francesco, Luti, Simone, Santi, Alice, Moschini, Roberta, Del Corso, Antonella, Paoli, Paolo, Ottanà, Rosaria

“…Type 2 diabetes mellitus (T2DM) is a serious chronic disease with an alarmingly growing worldwide prevalence. Current treatment of T2DM mainly relies on drug…”
Get full text

Structure–activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents by Maccari, Rosanna, Vitale, Rosa Maria, Ottanà, Rosaria, Rocchiccioli, Marco, Marrazzo, Agostino, Cardile, Venera, Graziano, Adriana Carol Eleonora, Amodeo, Pietro, Mura, Umberto, Del Corso, Antonella

“…A series of 5-(carbamoylmethoxy)benzylidene-2-oxo/thioxo-4-thiazolidinone derivatives (6–9) were synthesized as inhibitors of aldose reductase (AR), enzyme…”
Get full text

Low Molecular Weight Phosphotyrosine Protein Phosphatases as Emerging Targets for the Design of Novel Therapeutic Agents by Maccari, Rosanna, Ottanà, Rosaria

Get full text

Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents by Ottanà, Rosaria, Paoli, Paolo, Naß, Alexandra, Lori, Giulia, Cardile, Venera, Adornato, Ilenia, Rotondo, Archimede, Graziano, Adriana Carol Eleonora, Wolber, Gerhard, Maccari, Rosanna

“…New 4-{[5-arylidene-2-(4-fluorophenylimino)-4-oxothiazolidin-3-yl]methyl}benzoic acids (5) and 2-thioxo-4-thiazolidinone analogues (6) were synthesised as a…”
Get full text

Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B by Ottanà, Rosaria, Paoli, Paolo, Lori, Giulia, Adornato, Ilenia, Previti, Santo, Naß, Alexandra, Wolber, Gerhard, Maccari, Rosanna

“…[Display omitted] •5-arylidene-2-thioxo-4-imidazolidinones 7 are novel PTP1B allosteric inhibitors.•Most of compounds 7 proved to be interesting PTP1B…”
Get full text