Search Results - "Macaubas, C"

The role of allergy in the development of asthma by Holt, P G, Macaubas, C, Stumbles, P A, Sly, P D

“…Recent studies have shown that initial sensitization to airborne environmental allergens occurs typically in early childhood, but subsequent progression to…”
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Association between antenatal cytokine production and the development of atopy and asthma at age 6 years by Macaubas, C, de Klerk, NH, Holt, BJ, Wee, C, Kendall, G, Firth, M, Sly, PD, Holt, PG

“…Various lines of evidence suggest that antenatal factors are important in determining susceptibility to atopy and asthma. One possible mechanism is cytokines,…”
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B6.g7 mice reconstituted with BDC2·5 non‐obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes by Rajasekaran, N., Wang, N., Hang, Y., Macaubas, C., Rinderknecht, C., Beilhack, G. F., Shizuru, J. A., Mellins, E. D.

“…Summary In BDC2·5 non‐obese diabetic (BDC2·5NOD) mice, a spontaneous model of type 1 diabetes, CD4+ T cells express a transgene‐encoded T cell receptor (TCR)…”
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Development of long term tolerance versus sensitisation to environmental allergens during the perinatal period by Holt, PG, Macaubas, C

“…Evidence is steadily accumulating which indicates that the patterns of T cell reactivity against the environmental antigens that determine the allergen…”
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Antigen-Specific Responses to Diphtheria-Tetanus-Acellular Pertussis Vaccine in Human Infants Are Initially Th2 Polarized by ROWE, J, MACAUBAS, C, MONGER, T. M, HOLT, B. J, HARVEY, J, POOLMAN, J. T, SLY, P. D, HOLT, P. G

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Heterogeneity in Diphtheria-Tetanus–Acellular Pertussis Vaccine–Specific Cellular Immunity during Infancy: Relationship to Variations in the Kinetics of Postnatal Maturation of Systemic Th1 Function by Rowe, J., Macaubas, C., Monger, T., Holt, B. J., Harvey, J., Poolman, J. T., Loh, R., Sly, P. D., Holt, P. G.

“…Cellular immunity to vaccines is highly variable during infancy. This study addressed the hypothesis that these responses are governed by the pace of…”
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TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood by YABUHARA, A, MACAUBAS, C, PRESCOTT, S. L, VENAILLE, T. J, HOLT, B. J, HABRE, W, SLY, P. D, HOLT, P. G

“…There is increasing evidence that the T-cell reactivity to environmental allergens underlying expression of allergic disease in adulthood, develops initially…”
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Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants by Prescott, S L, Macaubas, C, Smallacombe, T, Holt, B J, Sly, P D, Loh, R, Holt, P G

“…By adulthood there is almost universal immunological memory to aeroallergens, and the presence of allergic disease appears to be related to the nature of the…”
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Regulation of T-helper cell responses to inhalant allergen during early childhood by MACAUBAS, C, SLY, P. D, BURTON, P, TILLER, K, YABUHARA, A, HOLT, B. J, SMALLACOMBE, T. B, KENDALL, G, JENMALM, M. C, HOLT, P. G

“…Background Recent evidence suggests that preschool children manifest patterns of allergen‐specific skin prick test (SPT) reactivity and in vitro T‐cell…”
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DQB10602 and DQA10102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and Black Americans by MIGNOT, E, LIN, X, ARRIGONI, J, MACAUBAS, C, OLIVE, F, HALLMAYER, J, UNDERHILL, P, GUILLEMINAULT, C, DEMENT, W. C, GRUMET, F. C

“…In the present study, we tested 19 Caucasian and 28 Black American narcoleptics for the presence of the human leucocyte antigen (HLA) DQB1*0602 and DQA1*0102…”
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Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody by Rowe, J., Poolman, J.T., Macaubas, C., Sly, P.D., Loh, R., Holt, P.G.

“…The known protective effects of passively acquired maternal antibody on the resistance of newborns to infections have prompted widespread interest in maternal…”
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Microbial stimulation as an aetiologic factor in atopic disease by Holt, P. G., Macaubas, C., Prescott, S. L., Sly, P. D.

“…Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of…”
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Reciprocal patterns of allergen-induced GATA-3 expression in peripheral blood mononuclear cells from atopics vs. non-atopics by Macaubas, C., Lee, P. T., Smallacombe, T. B., Holt, B. J., Wee, C., Sly, P. D., Holt, P. G.

“…Background T helper (Th)2 cytokines are considered to play a central role in the induction and expression of allergic disease. However, the relative importance…”
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“Bystander” amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children by Rudin, A., Macaubas, C., Wee, C., Holt, B. J., Slya, P. D., Holt, P. G.

“…Background: Atopic children show increased expression and production of the Th2‐associated cytokines IL‐4, IL‐5, IL‐13, and IL‐9 from PBMCs after stimulation…”
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The complex mutation pattern of a microsatellite by Macaubas, C, Jin, L, Hallmayer, J, Kimura, A, Mignot, E

“…DQCAR is a (CA)n microsatellite located in the HLA class II region and tightly linked to HLA-DQB1. Previous studies showed a strikingly low level of size…”
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Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses by Jenmalm, M. C., Björkstén, B., Macaubas, C., Holt, B. J., Smallacombe, T. B., Holt, P. G.

“…There are few studies on allergen‐induced cytokine production in allergic children, and little is known of antigen‐specific cytokine regulation of human…”
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Association Between Antenatal Cytokine Production and the Development of Atopy and Asthma at Age 6 Years by Macaubas, C, de Klerk, N. H, Holt, B. J, Wee, C, Kendall, G, Firth, M, Sly, P. D, Holt, P. G

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Strategic targets for primary prevention of allergic disease in childhood by Holt, P. G., Macaubas, C., Sly, P. D.

“…The progressive increase in the prevalence of allergic disease and the spiralling costs associated with treatment, particularly of chronic sufferers, provide…”
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Asthma: an epidemic of dysregulated immunity by Umetsu, Dale T, McIntire, Jennifer J, Akbari, Omid, Macaubas, Claudia, DeKruyff, Rosemarie H

“…The remarkable increase in asthma prevalence that has occurred over the last two decades is thought to be caused by changes in the environment due to improved…”
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Primary sensitization to inhalant allergens by Macaubas, Claudia, Prescott, Susan L., Venaille, Thierry J., Holt, Barbara J., Smallacombe, Troy B., Sly, Peter D., Holt, Patrick G.

“…The neonatal T‐cell system is capable of responding to allergens at birth, indicating the occurrence of prenatal sensitization, and the cytokine profile of…”
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