Search Results - "Macatangay, Bernard"

Level of Adherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy (HAART) by Viswanathan, Shilpa, Detels, Roger, Mehta, Shruti H., Macatangay, Bernard J. C., Kirk, Gregory D., Jacobson, Lisa P.

“…The need to achieve ≥95 % adherence to HAART for treatment effectiveness may be a barrier for universal initiation at early stages of HIV. Using longitudinal…”
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Suboptimal Adherence to Combination Antiretroviral Therapy Is Associated With Higher Levels of Inflammation Despite HIV Suppression by Castillo-Mancilla, Jose R., Brown, Todd T., Erlandson, Kristine M., Palella, Frank J., Gardner, Edward M., Macatangay, Bernard J. C., Breen, Elizabeth C., Jacobson, Lisa P., Anderson, Peter L., Wada, Nikolas I.

“…Background. Human immunodeficiency virus (HIV)-infected individuals exhibit residual inflammation regardless of virologic suppression. We evaluated whether…”
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T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy by Macatangay, Bernard J.C., Gandhi, Rajesh T., Jones, Richard B., Mcmahon, Deborah K., Lalama, Christina M., Bosch, Ronald J., Cyktor, Joshua C., Thomas, Allison S., Borowski, Luann, Riddler, Sharon A., Hogg, Evelyn, Stevenson, Eva, Eron, Joseph J., Mellors, John W., Rinaldo, Charles R.

“…OBJECTIVE:We evaluated frequencies of T cells with high PD-1 expression (PD-1) before and after long-term effective antiretroviral therapy (ART), and…”
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Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation by Gandhi, Rajesh T, McMahon, Deborah K, Bosch, Ronald J, Lalama, Christina M, Cyktor, Joshua C, Macatangay, Bernard J, Rinaldo, Charles R, Riddler, Sharon A, Hogg, Evelyn, Godfrey, Catherine, Collier, Ann C, Eron, Joseph J, Mellors, John W

“…Antiretroviral therapy (ART) reduces levels of HIV-1 and immune activation but both can persist despite clinically effective ART. The relationships among…”
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Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study by Hensley, Matthew K, Bain, William G, Jacobs, Jana, Nambulli, Sham, Parikh, Urvi, Cillo, Anthony, Staines, Brittany, Heaps, Amy, Sobolewski, Michele D, Rennick, Linda J, Macatangay, Bernard J C, Klamar-Blain, Cynthia, Kitsios, Georgios D, Methé, Barbara, Somasundaram, Ashwin, Bruno, Tullia C, Cardello, Carly, Shan, Feng, Workman, Creg, Ray, Prabir, Ray, Anuradha, Lee, Janet, Sethi, Rahil, Schwarzmann, William E, Ladinsky, Mark S, Bjorkman, Pamela J, Vignali, Dario A, Duprex, W Paul, Agha, Mounzer E, Mellors, John W, McCormick, Kevin D, Morris, Alison, Haidar, Ghady

“…A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2…”
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Suppressed renoprotective purines in COVID-19 patients with acute kidney injury by Jackson, Edwin K., Kitsios, Georgios D., Lu, Michael Y., Schaefer, Caitlin M., Kessinger, Cathy J., McVerry, Bryan J., Morris, Alison, Macatangay, Bernard J. C.

“…Acute kidney injury (AKI) is common in patients hospitalized for COVID-19, complicating their clinical course and contributing to worse outcomes. Animal…”
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The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation by Wada, Nikolas Itaru, Jacobson, Lisa P, Margolick, Joseph B, Breen, Elizabeth Crabb, Macatangay, Bernard, Penugonda, Sudhir, Martínez-Maza, Otoniel, Bream, Jay H

“…OBJECTIVES:To investigate the impact of HAART-induced HIV suppression on levels of 24 serological biomarkers of inflammation and immune activation. DESIGN:A…”
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TIM-3 signaling contributes to the suppressive capacity of Tregs from people with HIV on antiretroviral therapy by Nieves-Rosado, Hector M, Jacobs, Jana L, Naqvi, Asma, Mellors, John W, Macatangay, Bernard J C, Kane, Lawrence P

“…TIM-3 expression is increased on peripheral regulatory T cells (Tregs) of virally suppressed persons with HIV-1 on antiretroviral therapy (PWH-ART). However,…”
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Suspected Immune-Related Adverse Events With an Anti-PD-1 Inhibitor in Otherwise Healthy People With HIV by Gay, Cynthia L., Bosch, Ronald J., McKahnn, Ashley, Moseley, Kendall F., Wimbish, Chanelle L., Hendrickx, Steven M., Messer, Michael, Furlong, Maureen, Campbell, Danielle M., Jennings, Cheryl, Benson, Constance, Overton, Edgar T., Macatangay, Bernard J. C., Kuritzkes, Daniel R., Miller, Elizabeth, Tressler, Randall, Eron, Joseph J., Hardy, William David

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Viremia copy-years and mortality among combination antiretroviral therapy-initiating HIV-positive individuals: how much viral load history is enough? by Wang, Ruibin, Haberlen, Sabina A, Palella, Frank J, Mugavero, Michael J, Margolick, Joseph B, Macatangay, Bernard J.C, Martínez-Maza, Otoniel, Jacobson, Lisa P, Abraham, Alison G

“…OBJECTIVE:Ongoing HIV replication while receiving combination antiretroviral therapy (cART) may reduce survival. Viremia copy-years (VCY) has shown improved…”
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A Randomized, Placebo-Controlled, Pilot Clinical Trial of Dipyridamole to Decrease Human Immunodeficiency Virus–Associated Chronic Inflammation by Macatangay, Bernard J C, Jackson, Edwin K, Abebe, Kaleab Z, Comer, Diane, Cyktor, Joshua, Klamar-Blain, Cynthia, Borowski, Luann, Gillespie, Delbert G, Mellors, John W, Rinaldo, Charles R, Riddler, Sharon A

“…Abstract Background Adenosine is a potent immunoregulatory nucleoside produced during inflammatory states to limit tissue damage. We hypothesized that…”
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Therapy With Allogeneic Severe Acute Respiratory Syndrome Coronavirus-2–Specific T Cells for Persistent Coronavirus Disease 2019 in Immunocompromised Patients by Haidar, Ghady, Jacobs, Jana L, Kramer, Kailey Hughes, Naqvi, Asma, Heaps, Amy, Parikh, Urvi, McCormick, Kevin D, Sobolewski, Michele D, Agha, Mounzer, Bogdanovich, Tatiana, Bushunow, Vasilii, Farah, Rafic, Hensley, Matthew, Hsu, Yen-Michael S, Johnson, Bruce, Klamar-Blain, Cynthia, Kozar, Jennifer, Lendermon, Elizabeth, Macatangay, Bernard J C, Marino, Christopher C, Raptis, Anastasios, Salese, Erin, Silveira, Fernanda P, Leen, Ann M, Marshall, William L, Miller, Michael, Patel, Badrish, Atillasoy, Ercem, Mellors, John W

“…Abstract We administered severe acute respiratory syndrome coronavirus-2 viral-specific T cells (VSTs) under emergency investigational new drug applications to…”
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Subclinical herpesvirus shedding among HIV-1-infected men on antiretroviral therapy by Agudelo-Hernandez, Arcadio, Chen, Yue, Bullotta, Arlene, Buchanan, William G, Klamar-Blain, Cynthia R, Borowski, Luann, Riddler, Sharon A, Rinaldo, Charles R, Macatangay, Bernard J.C

“…OBJECTIVE:We evaluated the subclinical shedding of six different herpesviruses in antiretroviral drug-treated HIV-positive [HIV(+)] MSM, and determined how…”
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Antiretroviral Therapy Intensification for Neurocognitive Impairment in Human Immunodeficiency Virus by Letendre, Scott L, Chen, Huichao, McKhann, Ashley, Roa, Jhoanna, Vecchio, Alyssa, Daar, Eric S, Berzins, Baiba, Hunt, Peter W, Marra, Christina M, Campbell, Thomas B, Coombs, Robert W, Ma, Qing, Swaminathan, Shobha, Macatangay, Bernard J C, Morse, Gene D, Miller, Thomas, Rusin, David, Greninger, Alexander L, Ha, Belinda, Alston-Smith, Beverly, Robertson, Kevin, Paul, Robert, Spudich, Serena

“…Abstract Background Neurocognitive impairment (NCI) in people with HIV (PWH) on antiretroviral therapy (ART) is common and may result from persistent HIV…”
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Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy by Gandhi, Rajesh T, Cyktor, Joshua C, Bosch, Ronald J, Mar, Hanna, Laird, Gregory M, Martin, Albine, Collier, Ann C, Riddler, Sharon A, Macatangay, Bernard J, Rinaldo, Charles R, Eron, Joseph J, Siliciano, Janet D, McMahon, Deborah K, Mellors, John W

“…Abstract Background HIV-1 proviruses persist in people on antiretroviral therapy (ART) but most are defective and do not constitute a replication-competent…”
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Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019 by Castanha, Priscila M S, Tuttle, Dylan J, Kitsios, Georgios D, Jacobs, Jana L, Braga-Neto, Ulisses, Duespohl, Matthew, Rathod, Sanjay, Marti, Michelle M, Wheeler, Sarah, Naqvi, Asma, Staines, Brittany, Mellors, John, Morris, Alison, McVerry, Bryan J, Shah, Faraaz, Schaefer, Caitlin, Macatangay, Bernard J C, Methe, Barbara, Fernandez, Christian A, Barratt-Boyes, Simon M, Burke, Donald, Marques, Ernesto T A

“…Abstract Background Excessive complement activation has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19), but the mechanisms leading…”
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Prospective Assessment of Humoral and Cellular Immune Responses to a Third COVID-19 mRNA Vaccine Dose Among Immunocompromised Individuals by Haidar, Ghady, Hodges, Jacob C, Bilderback, Andrew, Lukanski, Amy, Linstrum, Kelsey, Postol, Barbara, Troyan, Rachel, Wisniewski, Mary K, Coughenour, Lindsay, Heaps, Amy, Jacobs, Jana L, Hughes Kramer, Kailey, Klamar-Blain, Cynthia, Kohl, Joshua, Liang, Wendy, Morris, Benjamin, Macatangay, Bernard J C, Parikh, Urvi M, Sobolewksi, Michele D, Musgrove, Christopher, Crandall, Melissa D, Mahon, John, Mulvey, Katie, Collins, Kevin, King, Adam C, Wells, Alan, Zapf, Rachel, Agha, Mounzer, Minnier, Tami, Angus, Derek C, Mellors, John W

“…Improved coronavirus disease 2019 (COVID-19) prevention is needed for immunocompromised individuals. A prospective study was performed of health care workers…”
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Editorial: Advances in T Cell Therapeutic Vaccines for HIV by Macatangay, Bernard J C, Landay, Alan L, Garcia, Felipe, Rinaldo, Charles R

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Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions by Garcia-Bates, Tatiana M, Palma, Mariana L, Shen, Chengli, Gambotto, Andrea, Macatangay, Bernard J C, Ferris, Robert L, Rinaldo, Charles R, Mailliard, Robbie B

“…Eliciting highly functional CD8 cytotoxic T lymphocyte (CTL) responses against a broad range of epitopes will likely be required for immunotherapeutic control…”
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Prospective Evaluation of Coronavirus Disease 2019 (COVID-19) Vaccine Responses Across a Broad Spectrum of Immunocompromising Conditions: the COVID-19 Vaccination in the Immunocompromised Study (COVICS) by Haidar, Ghady, Agha, Mounzer, Bilderback, Andrew, Lukanski, Amy, Linstrum, Kelsey, Troyan, Rachel, Rothenberger, Scott, McMahon, Deborah K, Crandall, Melissa D, Sobolewksi, Michele D, Nathan Enick, P, Jacobs, Jana L, Collins, Kevin, Klamar-Blain, Cynthia, Macatangay, Bernard J C, Parikh, Urvi M, Heaps, Amy, Coughenour, Lindsay, Schwartz, Marc B, Dueker, Jeffrey M, Silveira, Fernanda P, Keebler, Mary E, Humar, Abhinav, Luketich, James D, Morrell, Matthew R, Pilewski, Joseph M, McDyer, John F, Pappu, Bhanu, Ferris, Robert L, Marks, Stanley M, Mahon, John, Mulvey, Katie, Hariharan, Sundaram, Updike, Glenn M, Brock, Lorraine, Edwards, Robert, Beigi, Richard H, Kip, Paula L, Wells, Alan, Minnier, Tami, Angus, Derek C, Mellors, John W

“…Abstract Background We studied humoral responses after coronavirus disease 2019 (COVID-19) vaccination across varying causes of immunodeficiency. Methods…”
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