Search Results - "Macaskill, EJ"

Abstract P2-08-02: Interaction of PIK3CA mutation subclasses with response to preoperative treatment with the PI3K inhibitor pictilisib in patients with estrogen receptor-positive breast cancer by Schmid, P, Pinder, S, Wheatley, D, Zummit, C, Macaskill, EJ, Hu, J, Price, R, Bundred, N, Hadad, S, Shia, A, Sarker, S-J, Lim, L, Mousa, K, O'Brien, C, Wilson, TR, Lackner, MR, Gendreau, S, Gazinska, P, Korbie, D, Trau, M, Mainwaring, P, Thompson, A, Purushotham, A

“…Abstract Background: Although preclinical data suggest that combining PI3K inhibitors with endocrine therapy may overcome resistance, results from randomized…”
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Preoperative assessment of breast volume to aid surgical planning: comparison of software-based mammographic measurements with subsequent mastectomy volumes by Teo, I, Whelehan, P, Macaskill, EJ, Munnoch, D Alex, Vinnicombe, S, Evans, Andy

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P3-12-04: Involved Anterior Margins after Breast Conserving Surgery: Is Re-Excision Required? by Mullen, R, Macaskill, EJ, Khalil, A, Elseedawy, E, Brown, DC, Lee, AC, Purdie, C, Jordan, L, Thompson, AM

“…Abstract Background: Complete tumour excision in breast conserving surgery (BCS) is critical for successful treatment; involved circumferential resection…”
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Transcriptional profiling of patient-matched ER-positive breast cancer tissue from post-menopausal women treated with neoadjuvant RAD001 by Sabine, VS, Sims, AH, Macaskill, EJ, Renshaw, L, Thomas, JS, Dixon, JM, Bartlett, JM

“…Abstract Abstract #2035 Background: RAD001 (everolimus) is a rapamycin derivative that inhibits mTOR and its downstream substrates and has shown promising…”
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Mutation of PI3KCA in post-menopausal women with breast cancer and response to RAD001 treatment by Sabine, VS, Ferguson, J, Thelwell, N, Macaskill, EJ, Renshaw, L, Whitcombe, D, Thomas, JS, Dixon, JM, Bartlett, JM

“…Abstract Abstract #4063 Background: The activation of the PI3K-AKT pathway produces abnormalities in cell growth, proliferation and survival in a number of…”
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A randomised study comparing the effects of anastrozole and letrozole on lipid metabolism by McCaig, FM, Renshaw, L, Williams, L, Young, O, Murray, J, Macaskill, EJ, McHugh, M, Riermersma, R, Dixon, JM

“…Abstract Abstract #1152 Background:
 Aromatase inhibitors (AIs) reduce circulating oestrogen which may have a detrimental effect on lipid metabolism. Letrozole…”
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A randomised study of the effects of anastrozole (A), letrozole (L) and exemestane (E) on bone turnover by McCaig, FM, Renshaw, L, Williams, L, Young, O, Murray, J, Macaskill, EJ, McHugh, M, Hannon, R, Dixon, J

“…Abstract Abstract #1145 Background:
 Aromatase inhibitors (AIs) reduce circulating oestrogen which increases bone turnover. L decreases circulating oestrogen…”
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A randomised study comparing the effects of anastrozole (A), letrozole (L), exemestane (E) and tamoxifen (T) on coagulation by McCaig, FM, Renshaw, L, Williams, L, Young, O, Murray, J, Macaskill, EJ, McHugh, M, Dawson, P, Dixon, J

“…Abstract Abstract #1132 Background:
 Aromatase inhibitors (AIs) reduce circulating oestrogens and so should have either no or a positive effect on coagulation…”
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Predicting response to RAD001 treatment in post-menopausal women with ER-positive breast cancer using the breast cancer DSA™ research tool (Almac) by Sabine, VS, McCulla, A, Wilson, CL, Sims, AH, McDyer, F, McCluskey, C, Halfpenny, I, Oliver, GR, Macaskill, EJ, Renshaw, L, Thomas, JS, Dixon, JM, Bartlett, JM

“…Abstract Abstract #2032 Background: RAD001 (everolimus) is a rapamycin derivative that inhibits mTOR and its downstream substrates and has shown promising…”
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Surgical issues surrounding use of aromatase inhibitors by Dixon, J. Michael, Renshaw, Lorna, Murray, Juliette, Macaskill, E. Jane, Young, Oliver, Miller, William R.

“…There are important surgical issues related to the use of the third generation aromatase inhibitors in both the neoadjuvant and adjuvant settings. Neoadjuvant…”
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