Search Results - "Macarron, R"

Critical review of the role of HTS in drug discovery by Macarron, Ricardo

“…‘A wise use of lead discovery tactics will distinguish successful drug discovery engines.’…”
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A Homogeneous Method to Measure Aminoacyl-tRNA Synthetase Aminoacylation Activity Using Scintillation Proximity Assay Technology by Macarrón, Ricardo, Mensah, Lucy, Cid, Concha, Carranza, Carmen, Benson, Neil, Pope, Andrew J., Dı́ez, Emilio

“…A new method to measure the aminoacylation of tRNA based upon the use of the scintillation proximity assay (SPA) technology has been developed. The assay…”
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Mode of action of endoglucanase III from Trichoderma reesei by Macarron, R, Acebal, C, Castillon, M.P, Dominguez, J.M, Mata, I. de la, Pettersson, G, Tomme, P, Claeyssens, M

“…Endoglucanase III (EG III) was purified to homogeneity from the culture medium of Trichoderma reesei QM 9414. It has a molecular mass of 48 kDa, and an…”
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Mannanase activity of Endoglucanase III from Trichoderma reesei QM9414 by Macarron, R, Acebal, C, Castillon, M.P, Claeyssens, M

“…The cellulase and beta-mannanase activities of Endoglucanase III from Trichoderma reesei can be attributed to the same active site. Reversible and irreversible…”
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Identification of an essential glutamate residue in the active site of endoglucanase III from Trichoderma reesei by Macarron, Ricardo, van Beeumen, Jozef, Henrissat, Bernard, de la Mata, Isabel, Claeyssens, Marc

“…n-Propyl, n-butyl and n-pentyl β-cellobiosides with a reactive ω-epoxide in their aglycon completely and irreversibly inactivate endoglucanase III from…”
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Identification of novel isoform-selective inhibitors within class I histone deacetylases by Hu, Erding, Dul, Edward, Sung, Chiu-Mei, Chen, Zunxuan, Kirkpatrick, Robert, Zhang, Gui-Feng, Johanson, Kyung, Liu, Ronggang, Lago, Amparo, Hofmann, Glenn, Macarron, Ricardo, de los Frailes, Maite, Perez, Paloma, Krawiec, John, Winkler, James, Jaye, Michael

“…Histone deacetylases (HDACs) represent an expanding family of protein modifying-enzymes that play important roles in cell proliferation, chromosome remodeling,…”
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Chemical mechanism of beta-glucosidase from Trichoderma reesei QM 9414: pH-dependence of kinetic parameters by Mata, I. de la, Estrada, P, Macarron, R, Dominguez, J.M, Castillon, M.P, Acebal, C

“…The variation of kinetic parameters of beta-glucosidase from Trichoderma reesei QM 9414 with pH was used to gain information about the chemical mechanism of…”
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Family A cellulases: two essential tryptophan residues in endoglucanase III from Trichoderma reesei by Macarrón, R, Henrissat, B, Claeyssens, M

“…Three tryptophan residues are readily oxidised by N-bromosuccinimide in endoglucanase III from Trichoderma reesei. Evidence was obtained that the residue first…”
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Mechanisms of thermoinactivation of endoglucanase I from Trichoderma reesei QM 9414 by Dominguez, J.M, Acebal, C, Jimenez, J, Mata, I. de la, Macarron, R, Castillon, M.P

“…The mechanism of irreversible thermoinactivation of endoglucanase I from Trichoderma reesei has been determined at 70 degrees C at the pH of maximum enzyme…”
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Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase by Dhanak, Dashyant, Duffy, Kevin J., Johnston, Victor K., Lin-Goerke, Juili, Darcy, Michael, Shaw, Antony N., Gu, Baohua, Silverman, Carol, Gates, Adam T., Nonnemacher, Michael R., Earnshaw, David L., Casper, David J., Kaura, Arun, Baker, Audrey, Greenwood, Cathy, Gutshall, Lester L., Maley, Derrick, DelVecchio, Alfred, Macarron, Ricardo, Hofmann, Glenn A., Alnoah, Zaid, Cheng, Hung-Yuan, Chan, George, Khandekar, Sanjay, Keenan, Richard M., Sarisky, Robert T.

“…The hepatitis C virus (HCV) NS5B protein encodes an RNA-dependent RNA polymerase (RdRp), the primary catalytic enzyme of the HCV replicase complex. We…”
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Ultra high quality uHTS by Macarrón, Ricardo

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Chemical modification of beta-glucosidase from Trichoderma reesei QM 9414 by de la Mata, I, Castillón, M P, Domínguez, J M, Macarrón, R, Acebal, C

“…The inhibition of beta-glucosidase from Trichoderma reesei QM 9414 by several specific reagents was studied. Diethylpyrocarbonate (DEP) nearly abolished the…”
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A standard operating procedure for assessing liquid handler performance in high-throughput screening by Taylor, Paul B, Ashman, Stephen, Baddeley, Stuart M, Bartram, Stacy L, Battle, Clive D, Bond, Brian C, Clements, Yvonne M, Gaul, Nathan J, McAllister, W Elliot, Mostacero, Juan A, Ramon, Fernando, Wilson, Jamie M, Hertzberg, Robert P, Pope, Andrew J, Macarron, Ricardo

“…The thrust of early drug discovery in recent years has been toward the configuration of homogeneous miniaturized assays. This has allowed organizations to…”
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Synergism of Trichoderma reesei cellulases while degrading different celluloses by Nidetzky, B, Hayn, M, Macarron, R, Steiner, W

“…The synergistic action of purified cellulases from Trichoderma reesei in hydrolysis of cellulose decreased with increasing substrate concentration, depended…”
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The effect of triton concentration on the activity of undecaprenyl pyrophosphate synthase inhibitors by Li, Hu, Huang, Jianzhong, Jiang, Xinhe, Seefeld, Mark, McQueney, Michael, Macarron, Ricardo

“…Undecaprenyl pyrophosphate synthase (UPPS) catalyzes the consecutive condensation of 8 molecules of isopentenyl pyrophosphate with farnesyl pyrophosphate to…”
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Novel antibacterials: a genomics approach to drug discovery by Chan, Pan F, Macarron, Ricardo, Payne, David J, Zalacain, Magdalena, Holmes, David J

“…The appearance of antibiotic resistant pathogens, including vancomycin resistant Staphylococcus aureus, in the clinic has necessitated the development of new…”
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