Search Results - "Macara, IG"

Parsing the Polarity Code by Macara, Ian G

“…Cell polarization is used both to mediate physical fates, as, for example, in orientated cell migration, and to specify differential phenotypic fates, as in…”
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Mammalian Pins Is a Conformational Switch that Links NuMA to Heterotrimeric G Proteins by Du, Quansheng, Macara, Ian G.

“…During asymmetric cell divisions, mitotic spindles align along the axis of polarization. In invertebrates, spindle positioning requires Pins or related…”
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Transport into and out of the Nucleus by MACARA, Ian G

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Par-3 controls tight junction assembly through the Rac exchange factor Tiam1 by Chen, Xinyu, Macara, Ian G

“…The par (partitioning-defective) genes express a set of conserved proteins that function in polarization and asymmetric cell division. Par-3 has multiple…”
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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs by Yi, Rui, Qin, Yi, Macara, Ian G, Cullen, Bryan R

“…MicroRNAs (miRNAs) are initially expressed as long transcripts that are processed in the nucleus to yield approximately 65-nucleotide (nt) RNA hairpin…”
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The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis by Zhang, Huaye, Macara, Ian G

“…PAR-3 (partitioning-defective gene 3) is essential for cell polarization in many contexts, including axon specification. However, polarity proteins have not…”
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mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin by Qin, Yi, Capaldo, Christopher, Gumbiner, Barry M, Macara, Ian G

“…Scribble (Scrib) is a conserved polarity protein required in Drosophila melanogaster for synaptic function, neuroblast differentiation, and epithelial…”
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A Systems Analysis of Importin-α-β Mediated Nuclear Protein Import by Riddick, Gregory, Macara, Ian G.

“…Importin-β (Impβ) is a major transport receptor for Ran-dependent import of nuclear cargo. Impβ can bind cargo directly or through an adaptor such as…”
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Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells by McNeil, Elizabeth, Capaldo, Christopher T, Macara, Ian G

“…Zonula occludens (ZO)-1 was the first tight junction protein to be cloned and has been implicated as an important scaffold protein. It contains multiple…”
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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 by Joberty, Gérard, Petersen, Clark, Gao, Lin, Macara, Ian G

“…PAR (partitioning-defective) proteins, which were first identified in the nematode Caenorhabditis elegans, are essential for asymmetric cell division and…”
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Abstract P1-06-05: Breast cancer organoid cultures preserve intra-tumor heterogeneity and reveal intrinsically resistant phenotypes to standard chemotherapies by Sowder, ME, Ludwik, KA, Pasic, L, Brenin, DR, Stricker, TP, Macara, IG, Lannigan, DA

“…Breast cancer intra-tumor heterogeneity contributes to chemotherapy resistance and decreased patient survival, yet no reliable in vitro models exist to study…”
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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly by Macara, Ian G, Margolis, Ben, Hurd, Toby W, Gao, Lin, Roh, Michael H

“…Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Two…”
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Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs by Yi, Rui, Doehle, Brian P, Qin, Yi, Macara, Ian G, Cullen, Bryan R

“…Plasmids or viral vectors that express short hairpin RNAs (shRNAs) have emerged as important tools for the stable inhibition of specific genes by RNA…”
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Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex by Ravichandran, Kodimangalam S, Brugnera, Enrico, Haney, Lisa, Grimsley, Cynthia, Lu, Mingjian, Walk, Scott F, Tosello-Trampont, Annie-Carole, Macara, Ian G, Madhani, Hiten, Fink, Gerald R

“…Mammalian Dock180 and ELMO proteins, and their homologues in Caenorhabditis elegans and Drosophila melanogaster, function as critical upstream regulators of…”
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Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly by Chen, Xinyu, Macara, Ian G

“…The polarity protein Par-3 plays critical roles in axon specification and the establishment of epithelial apico-basal polarity. Par-3 associates with Par-6 and…”
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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10 by Saltiel, Alan R, Chiang, Shian-Huey, Baumann, Christian A, Kanzaki, Makoto, Thurmond, Debbie C, Watson, Robert T, Neudauer, Cheryl L, Macara, Ian G, Pessin, Jeffrey E

“…The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter protein from intracellular…”
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Inhibition of Nuclear Import by Protein Kinase B (Akt) Regulates the Subcellular Distribution and Activity of the Forkhead Transcription Factor AFX by Brownawell, Amy M., Kops, Geert J. P. L., Macara, Ian G., Burgering, Boudewijn M. T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration by Gumienny, Tina L., Brugnera, Enrico, Tosello-Trampont, Annie-Carole, Kinchen, Jason M., Haney, Lisa B., Nishiwaki, Kiyoji, Walk, Scott F., Nemergut, Michael E., Macara, Ian G., Francis, Ross, Schedl, Tim, Qin, Yi, Van Aelst, Linda, Hengartner, Michael O., Ravichandran, Kodimangalam S.

“…The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII, dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis…”
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A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization by Du, Quansheng, Stukenberg, P. Todd, Macara, Ian G

“…Asymmetric cell division requires the orientation of mitotic spindles along the cell-polarity axis. In Drosophila neuroblasts, this involves the interaction of…”
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Isoforms of the Polarity Protein Par6 Have Distinct Functions by Gao, Lin, Macara, Ian G

“…PAR-6 is essential for asymmetric division of the Caenorhabditis elegans zygote. It is also critical for cell polarization in many other contexts throughout…”
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