Biomarkers of Osteoarthritis-A Narrative Review on Causal Links with Metabolic Syndrome

Biomarkers of Osteoarthritis-A Narrative Review on Causal Links with Metabolic Syndrome

Development of OA (OA) is multifactorial and is strongly associated with risk factors such as aging, trauma, metabolic disorders, and obesity. Metabolic Syndrome (MetS)-associated OA, collectively coined MetS-OA, is an increasingly recognized entity in which metabolic disorders and low-grade inflamm...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Vol. 13; no. 3; p. 730
Main Authors: Lynskey, Samuel James, Macaluso, Marc Julian, Gill, Stephen D, McGee, Sean L, Page, Richard S
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-03-2023
MDPI
Subjects:
Arthritis
Biochemical markers
Biological markers
Biomarkers
Cartilage
Cartilage diseases
Complications and side effects
Constituents
Development and progression
Diagnosis
Homeostasis
Inflammation
Insulin resistance
Medical research
Medicine, Experimental
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome associated OA
Metabolic syndrome X
MetS-OA
Narratives
Obesity
omics
Osteoarthritis
Review
Risk factors
transcriptomics
Australia
metabolic syndrome
transcriptomics
MetS-OA
Metabolic Syndrome associated OA
omics
osteoarthritis
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Summary:Development of OA (OA) is multifactorial and is strongly associated with risk factors such as aging, trauma, metabolic disorders, and obesity. Metabolic Syndrome (MetS)-associated OA, collectively coined MetS-OA, is an increasingly recognized entity in which metabolic disorders and low-grade inflammation play a key mechanistic role in the disruption of joint homeostasis and cartilage degradation. Although there have been enormous efforts to discover biomarkers of MetS and OA, studies investigating a pathophysiological link between MetS and OA are relatively limited, and no serum blood marker has proved diagnostic so far. OA biomarkers that are necessary to discriminate and diagnose early disease remain to be elicited, explained in part by limited prospective studies, and therefore limited tools available to utilize in any prognostic capacity. Biomarker validation projects have been established by the Biomarker Consortium to determine biochemical markers demonstrating predictive validity for knee OA. Given that the metabolic constituents of MetS are treatable to varying extents, it stands to reason that treating these, and monitoring such treatment, may help to mitigate deleterious links with OA development. This narrative review will describe the current state of biomarker identification and utility in OA associated with MetS. We discuss the pathophysiological mechanisms of disease according to constituent pathologies of MetS and how identification of biomarkers may guide future investigation of novel targets.
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ObjectType-Review-1
ISSN:2075-1729
2075-1729
DOI:10.3390/life13030730