Search Results - "MacRae, V E"

Metformin ameliorates valve interstitial cell calcification by promoting autophagic flux by Phadwal, K., Tan, X., Koo, E., Zhu, D., MacRae, V. E.

“…Calcific aortic valve disease (CAVD) is the most common heart disease of the developed world. It has previously been established that metformin administration…”
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Endocrine role of bone: recent and emerging perspectives beyond osteocalcin by Oldknow, K J, MacRae, V E, Farquharson, C

“…Recent developments in endocrinology, made possible by the combination of mouse genetics, integrative physiology and clinical observations have resulted in…”
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Large animal models of cardiovascular disease by Tsang, H. G., Rashdan, N. A., Whitelaw, C. B. A., Corcoran, B. M., Summers, K. M., MacRae, V. E.

“…The human cardiovascular system is a complex arrangement of specialized structures with distinct functions. The molecular landscape, including the genome,…”
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New insights into NPP1 function: Lessons from clinical and animal studies by Mackenzie, N.C.W, Huesa, C, Rutsch, F, MacRae, V.E

“…Abstract The recent elucidation of rare human genetic disorders resulting from mutations in ectonucleotide pyrophosphotase/phosphodiesterase ( ENPP1 ), also…”
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Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel by Markby, G R, Macrae, V E, Corcoran, B M, Summers, K M

“…Almost all elderly dogs develop myxomatous mitral valve disease by the end of their life, but the cavalier King Charles spaniel (CKCS) has a heightened…”
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miRNA-221 and miRNA-222 synergistically function to promote vascular calcification by Mackenzie, N. C. W., Staines, K. A., Zhu, D., Genever, P., MacRae, V. E.

“…Vascular calcification shares many similarities with skeletal mineralisation and involves the phenotypic trans‐differentiation of vascular smooth muscle cells…”
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The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines by MacRae, V E, Farquharson, C, Ahmed, S F

“…Childhood chronic inflammatory disease can be associated with transient and permanent growth retardation. This study examined the potential for spontaneous…”
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MEPE is a novel regulator of growth plate cartilage mineralization by Staines, K.A, Mackenzie, N.C.W, Clarkin, C.E, Zelenchuk, L, Rowe, P.S, MacRae, V.E, Farquharson, C

“…Abstract Matrix extracellular phosphoglycoprotein (MEPE) belongs to the SIBLING protein family which play key roles in biomineralization. Although the growth…”
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The pathophysiology of the growth plate in juvenile idiopathic arthritis by MacRae, V. E., Farquharson, C., Ahmed, S. F.

“…Children with chronic inflammatory diseases, such as juvenile idiopathic arthritis (JIA), suffer from a variety of growth disorders. These range from general…”
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Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth by Pass, C., MacRae, V. E., Ahmed, S. F., Farquharson, C.

“…Longitudinal bone growth is a tightly regulated process that relies on complex synchronized mechanisms at the growth plate. Chronic paediatric inflammatory…”
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The Role of Pro‐Inflammatory Cytokines in Inflammatory Bowel Disease Growth Retardation by Wong, S.C., MacRae, V.E., McGrogan, P., Ahmed, S.F.

“…ABSTRACT Childhood inflammatory bowel disease (IBD) especially those with Crohn disease is commonly complicated by faltering growth and pubertal delay…”
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Characterisation of Matrix Vesicles in Skeletal and Soft Tissue Mineralisation by Cui, L, Houston, D.A, Farquharson, C, MacRae, V.E

“…Abstract The importance of matrix vesicles (MVs) have been repeatedly highlighted in the formation of cartilage, bone, and dentin since their discovery in…”
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Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent by MacRae, V E, Burdon, T, Ahmed, S F, Farquharson, C

“…Proinflammatory cytokines inhibit growth plate development. However, their underlying mechanisms of action are unclear. These effects may be mediated by…”
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Cytokine profiling and in vitro studies of murine bone growth using biological fluids from children with juvenile idiopathic arthritis by MacRae, V. E., Wong, S. C., Smith, W., Gracie, A., McInnes, I., Galea, P., Gardner-Medwin, J., Farquharson, C., Ahmed, S. F.

“…Summary Objective  Growth retardation in children with chronic inflammatory disease may be partly due to direct effects of pro‐inflammatory cytokines on the…”
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The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures by Houston, D. A., Myers, K., MacRae, V. E., Staines, K. A., Farquharson, C.

“…Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, is catabolic to bone. The increase in the RANKL/OPG ratio…”
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Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events by Markby, G., Summers, K.M., MacRae, V.E., Del-Pozo, J., Corcoran, B.M.

“…Myxomatous mitral valve disease (MMVD) is the single most common acquired heart disease of the dog, but is also of emerging importance in human medicine, with…”
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Evaluating invasive and non-invasive methods to determine fat content in the laboratory mouse by Oldknow, KJ, Macrae, VE, Farquharson, C, Bünger, L

“…In the midst of an obesity epidemic in humans, diet induced obesity studies in rodents are fundamental to unravel the complex mechanisms underlying this…”
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Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation by NEWTON, P.T, STAINES, K.A, SPEVAK, L, BOSKEY, A.L, TEIXEIRA, C.C, MACRAE, V.E, CANFIELD, A.E, FARQUHARSON, C

“…The development of chondrogenic cell lines has led to major advances in the understanding of how chondrocyte differentiation is regulated, and has uncovered…”
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Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2−/− mice by Dobie, R, MacRae, V E, Huesa, C, van't Hof, R, Ahmed, S F, Farquharson, C

“…The suppressor of cytokine signalling (Socs2−/−)-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of…”
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MOVAS-1 cell line: A new in vitro model of vascular calcification by Mackenzie, N, Zhu, D, Longley, L, Patterson, C, Kommareddy, S, MacRae, V

“…Vascular calcification has severe clinical consequences in a number of diseases, including diabetes, atherosclerosis and end-stage renal disease. The in vitro…”
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