Search Results - "MacPherson, Iain S."

High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12 by Temme, J. Sebastian, MacPherson, Iain S, DeCourcey, John F, Krauss, Isaac J

“…SELMA (SELection with Modified Aptamers) is a directed evolution method which can be used to develop DNA-supported clusters of carbohydrates in which the…”
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Selection of antibody-binding covalent aptamers by Soxpollard, Noah, Strauss, Sebastian, Jungmann, Ralf, MacPherson, Iain S.

“…Aptamers are oligonucleotides with antibody-like binding function, selected from large combinatorial libraries. In this study, we modified a DNA aptamer…”
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Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH by Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Sharling, Lisa, Zhang, Minjia, Liu, Xiaoping, Ray, Soumya S., MacPherson, Iain S., Striepen, Boris, Hedstrom, Lizbeth, Cuny, Gregory D.

“…Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes…”
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Cellular Uptake of Tile-Assembled DNA Nanotubes by Kocabey, Samet, Meinl, Hanna, MacPherson, Iain S, Cassinelli, Valentina, Manetto, Antonio, Rothenfusser, Simon, Liedl, Tim, Lichtenegger, Felix S

“…DNA-based nanostructures have received great attention as molecular vehicles for cellular delivery of biomolecules and cancer drugs. Here, we report on the…”
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Recent strategies targeting HIV glycans in vaccine design by Horiya, Satoru, MacPherson, Iain S, Krauss, Isaac J

“…Carbohydrate antigens on HIV are important for viral biology as well as for recognition by glycan-reactive broadly neutralizing antibodies such as 2G12. A…”
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Multivalent Glycocluster Design through Directed Evolution by MacPherson, Iain S., Temme, J. Sebastian, Habeshian, Sevan, Felczak, Krzysztof, Pankiewicz, Krzysztof, Hedstrom, Lizbeth, Krauss, Isaac J.

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An enzymatic atavist revealed in dual pathways for water activation by Min, Donghong, Josephine, Helen R, Li, Hongzhi, Lakner, Clemens, MacPherson, Iain S, Naylor, Gavin J P, Swofford, David, Hedstrom, Lizbeth, Yang, Wei

“…Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the biosynthesis of guanine nucleotides. This reaction involves two different…”
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Directed Evolution of 2G12-Targeted Nonamannose Glycoclusters by SELMA by Temme, J. Sebastian, Drzyzga, Michael G., MacPherson, Iain S., Krauss, Isaac J.

“…Optimizing multivalency: Clusters of Man9 glycans, which are recognized by broadly neutralizing anti‐HIV antibody 2G12, have potential as HIV vaccines…”
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The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity by MacPherson, Iain S, Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Riera, Thomas V, D’Aquino, J. Alejandro, Zhang, Minjia, Cuny, Gregory D, Hedstrom, Lizbeth

“…Cryptosporidium parvum is a potential biowarfare agent, an important AIDS pathogen, and a major cause of diarrhea and malnutrition. No vaccines or effective…”
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Directed evolution of copper nitrite reductase to a chromogenic reductant by MacPherson, Iain S., Rosell, Federico I., Scofield, Melanie, Mauk, A. Grant, Murphy, Michael E.P.

“…Directed evolution methods were developed for Cu-containing nitrite reductase (NiR) from Alcaligenes faecalis S-6. The PCR cloning strategy allows for the…”
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The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity by MacPherson, Iain S, Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Riera, Thomas V, D’Aquino, J. Alejandro, Zhang, Minjia, Cuny, Gregory D, Hedstrom, Lizbeth

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Multivalent Glycocluster Design through Directed Evolution by MacPherson, Iain S., Temme, J. Sebastian, Habeshian, Sevan, Felczak, Krzysztof, Pankiewicz, Krzysztof, Hedstrom, Lizbeth, Krauss, Isaac J.

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Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases by Gollapalli, Deviprasad R., MacPherson, Iain S., Liechti, George, Gorla, Suresh Kumar, Goldberg, Joanna B., Hedstrom, Lizbeth

“…The protozoan parasite Cryptosporidium parvum is a major cause of gastrointestinal disease; no effective drug therapy exists to treat this infection…”
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Multivalent Glycocluster Design through Directed Evolution by MacPherson, Iain S., Temme, J. Sebastian, Habeshian, Sevan, Felczak, Krzysztof, Pankiewicz, Krzysztof, Hedstrom, Lizbeth, Krauss, Isaac J.

“…Selection with modified aptamers: A method is described for design of glycocluster ligands by directed evolution. Glycan azides are attached to a library of…”
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Multivalent Glycocluster Design through Directed Evolution by MacPherson, Iain S., Temme, J. Sebastian, Habeshian, Sevan, Felczak, Krzysztof, Pankiewicz, Krzysztof, Hedstrom, Lizbeth, Krauss, Isaac J.

“…Selektion mit modifizierten Aptameren: Eine Methode für die Entwicklung von Glycoclusterliganden durch gerichtete Evolution wird beschrieben. Glycanazide…”
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Characterisation of a unique dipeptidase allele in an insular population of masked shrews, Sorex cinereus (Insectivora: Soricidae) by MacPherson, Iain S., Stewart, Donald T.

“…The masked shrew, Sorex cinereus, is found in extremely high densities on Bon Portage Island, off the southern coast of Nova Scotia, Canada. This population is…”
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