Search Results - "MacPherson, G. Gordon"

Prions and their lethal journey to the brain by Mabbott, Neil A, MacPherson, G. Gordon

“…Prion diseases are neurodegenerative conditions that cause extensive damage to nerve cells within the brain and can be fatal. Some prion disease agents…”
Get full text

Murine Cecal Patch M Cells Transport Infectious Prions In Vivo by Foster, Neil, Macpherson, Gordon G.

“…We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that…”
Get full text

Intestinal Dendritic Cell Subsets: Differential Effects of Systemic TLR4 Stimulation on Migratory Fate and Activation In Vivo by Turnbull, Emma L, Yrlid, Ulf, Jenkins, Christopher D, MacPherson, G. Gordon

“…Dendritic cells (DC) present peripheral Ags to T cells in lymph nodes, but also influence their differentiation (tolerance/immunity, Th1/Th2). To investigate…”
Get full text

Scrapie Pathogenesis: The Role of Complement C1q in Scrapie Agent Uptake by Conventional Dendritic Cells by Flores-Langarica, Adriana, Sebti, Yasmine, Mitchell, Daniel A, Sim, Robert B, MacPherson, Gordon G

“…Mice lacking complement components show delayed development of prion disease following peripheral inoculation. The delay could relate to reduced scrapie prion…”
Get full text

A distinct subset of intestinal dendritic cells responds selectively to oral TLR7/8 stimulation by Yrlid, Ulf, Cerovic, Vuk, Milling, Simon, Jenkins, Christopher D., Klavinskis, Linda S., MacPherson, G. Gordon

“…The intestinal innate immune system continually interacts with commensal bacteria, thus oral vaccines should induce extra/alternative activation of DC,…”
Get full text

Hyporesponsiveness of Intestinal Dendritic Cells to TLR Stimulation Is Limited to TLR4 by Cerovic, Vuk, Jenkins, Christopher D, Barnes, Andrew G. C, Milling, Simon W. F, MacPherson, G. Gordon, Klavinskis, Linda S

“…Dendritic cells (DCs) are crucial to intestinal immune regulation because of their roles in inducing protective immunity against pathogens while maintaining…”
Get full text

Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains by Ma, Liang, Chan, Kwok‐Wah, Trendell‐Smith, Nigel J., Wu, Adrian, Tian, Lina, Lam, Audrey C., Chan, Albert K., Lo, Chi‐Kin, Chik, Stanley, Ko, King‐Hung, To, Christina K. W., Kam, Siu‐Kee, Li, Xiao‐Song, Yang, Cui‐Hong, Leung, Suet Yi, Ng, Mun‐Hon, Stott, David I., MacPherson, G. Gordon, Huang, Fang‐Ping

“…Systemic lupus erythematosus (SLE) is an autoimmune disorder of a largely unknown etiology. Anti‐double‐stranded (ds) DNA antibodies are a classic hallmark of…”
Get full text

Relationships between Distinct Blood Monocyte Subsets and Migrating Intestinal Lymph Dendritic Cells In Vivo under Steady-State Conditions by Yrlid, Ulf, Jenkins, Christopher D, MacPherson, G. Gordon

“…The origins of dendritic cells (DCs) are poorly understood. In inflammation, DCs can arise from blood monocytes (M(O)s), but their steady-state origin may…”
Get full text

CD11c(high )dendritic cells are essential for activation of CD4+ T cells and generation of specific antibodies following mucosal immunization by Fahlén-Yrlid, Linda, Gustafsson, Tobias, Westlund, Jessica, Holmberg, Anna, Strömbeck, Anna, Blomquist, Margareta, MacPherson, Gordon G, Holmgren, Jan, Yrlid, Ulf

“…To generate vaccines that protect mucosal surfaces, a better understanding of the cells required in vivo for activation of the adaptive immune response…”
Get full text

Rat bone marrow‐derived dendritic cells, but not ex vivo dendritic cells, secrete nitric oxide and can inhibit T‐cell proliferation by Powell, Timothy J., Jenkins, Chris D., Hattori, Ryuichi, MacPherson, G. Gordon

“…Summary The relationships between different dendritic cell (DC) populations are not clearly established. In particular, it is not known how DC generated in…”
Get full text

CD11chigh Dendritic Cells Are Essential for Activation of CD4+ T Cells and Generation of Specific Antibodies following Mucosal Immunization by Fahlen-Yrlid, Linda, Gustafsson, Tobias, Westlund, Jessica, Holmberg, Anna, Strombeck, Anna, Blomquist, Margareta, MacPherson, Gordon G, Holmgren, Jan, Yrlid, Ulf

“…To generate vaccines that protect mucosal surfaces, a better understanding of the cells required in vivo for activation of the adaptive immune response…”
Get full text

Regulation of intestinal dendritic cell migration and activation by plasmacytoid dendritic cells, TNF-alpha and type 1 IFNs after feeding a TLR7/8 ligand by Yrlid, Ulf, Milling, Simon W F, Miller, Joanna L, Cartland, Sian, Jenkins, Christopher D, MacPherson, G Gordon

“…Dendritic cells (DCs) migrating via lymph are the primary influence regulating naive T cell differentiation, be it active immunity or tolerance. How DCs…”
Get full text

Plasmacytoid Dendritic Cells Do Not Migrate in Intestinal or Hepatic Lymph by Yrlid, Ulf, Cerovic, Vuk, Milling, Simon, Jenkins, Christopher D, Zhang, Jiquan, Crocker, Paul R, Klavinskis, Linda S, MacPherson, G. Gordon

“…Plasmacytoid dendritic cells (pDCs) recognize pathogen-associated molecules, particularly viral, and represent an important mechanism in innate defense. They…”
Get full text

Migrating intestinal dendritic cells transport PrPSc from the gut by Huang, Fang-Ping, Farquhar, Christine F, Mabbott, Neil A, Bruce, Moira E, MacPherson, G. Gordon

“…Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK 1 Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, West Mains…”
Get full text

Eosinophilic Bowel Disease Controlled by the BB Rat-Derived Lymphopenia/Gimap5 Gene by Cousins, Lesley, Graham, Margaret, Tooze, Reuben, Carter, Christine, Miller, J. Ross, Powrie, Fiona M., Macpherson, Gordon G., Butcher, Geoffrey W.

“…Background & Aims: Many models of autoimmunity are associated with lymphopenia. Most involve a T-helper cell (Th)1-type disease, including the diabetic…”
Get full text

How do DCs interact with intestinal antigens? by Milling, Simon W.F., Cousins, Lesley, MacPherson, G. Gordon

“…Recent evidence demonstrates that dendritic cells (DCs) can insert dendrites between the epithelial cells that form the barrier protecting the body from the…”
Get full text

Dendritic cells and oral transmission of prion diseases by Huang, Fang-Ping, MacPherson, G.Gordon

“…Transmissible spongiform encephalopathies (scrapie, BSE, Kuru) develop as central nervous system (CNS) diseases after long incubation periods, and many of…”
Get full text

Soluble CD38 significantly prolongs the lifespan of memory B-cell responses by Liu, Xue Q, Hart, Derek N.J, MacPherson, Gordon G, Good, Michael F, Wykes, Michelle N

“…The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously…”
Get full text

Dendritic cells and follicular dendritic cells express a novel ligand for CD38 which influences their maturation and antibody responses by Wykes, Michelle N., Beattie, Lynette, Macpherson, Gordon G., Hart, Derek N.

“…Summary CD38 is a cell surface molecule with ADP‐ribosyl cyclase activity, which is predominantly expressed on lymphoid and myeloid cells. CD38 has a…”
Get full text

Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells by Sanderson, Peter, MacPherson, G. Gordon, Jenkins, Chris H., Calder, Philip C.

“…Rats were fed for 6 weeks on a low fat (LF) diet or on high fat diets containing safflower oil [SO; rich in n‐6 polyunsaturated fatty acids (PUFAs)] or fish…”
Get full text