Search Results - "MacPhee, J."

Methodological considerations for improving Western blot analysis by MacPhee, Daniel J.

“…The need for a technique that could allow the determination of antigen specificity of antisera led to the development of a method that allowed the production…”
Get full text

Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases by Ma, Bin, Bohnert, Tonika, Otipoby, Kevin L, Tien, Eric, Arefayene, Million, Bai, Judy, Bajrami, Bekim, Bame, Eris, Chan, Timothy R, Humora, Michael, MacPhee, J. Michael, Marcotte, Douglas, Mehta, Devangi, Metrick, Claire M, Moniz, George, Polack, Evelyne, Poreci, Urjana, Prefontaine, Annick, Sheikh, Sarah, Schroeder, Patricia, Smirnakis, Karen, Zhang, Lei, Zheng, Fengmei, Hopkins, Brian T

“…Autoreactive B cell-derived antibodies form immune complexes that likely play a pathogenic role in autoimmune diseases. In systemic lupus erythematosus (SLE),…”
Get full text

Phosphoserine-86-HSPB1 (pS86-HSPB1) is cytoplasmic and highly induced in rat myometrium at labour by Miskiewicz, E. I., Olaloku, A., MacPhee, B. K., MacPhee, D. J.

“…Uterine myocytes during pregnancy proceed through a series of adaptations and collectively transform into a powerfully contractile tissue by term. Previous…”
Get full text

Maternal and fetal thyroid dysfunction following porcine reproductive and respiratory syndrome virus2 infection by Pasternak, J Alex, MacPhee, Daniel J, Harding, John C S

“…To better understand the host response to porcine reproductive and respiratory virus-2 (PRRSV2) we evaluated circulating thyroid hormone and associated gene…”
Get full text

Crystal Engineering of Novel Cocrystals of a Triazole Drug with 1,4-Dicarboxylic Acids by Remenar, Julius F, Morissette, Sherry L, Peterson, Matthew L, Moulton, Brian, MacPhee, J. Michael, Guzmán, Héctor R, Almarsson, Örn

“…Cocrystals of the poorly soluble antifungal drug cis-itraconazole (1) with 1,4-dicarboxylic acids have been prepared. The crystal structure of the succinic…”
Get full text

Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection by Van Goor, Angelica, Pasternak, Alex, Walker, Kristen, Hong, Linjun, Malgarin, Carolina, MacPhee, Daniel J, Harding, John C S, Lunney, Joan K

“…A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the…”
Get full text

A DIO2 missense mutation and its impact on fetal response to PRRSV infection by Ko, Haesu, Pasternak, J Alex, Mulligan, Margaret K, Hamonic, Glenn, Ramesh, Naresh, MacPhee, Daniel J, Plastow, Graham S, Harding, John C S

“…Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) infection during late gestation substantially lowers fetal viability and survival. In a…”
Get full text

Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing by Trementozzi, Andrea N., Leung, Cheuk-Yui, Osei-Yeboah, Frederick, Irdam, Erwin, Lin, Yiqing, MacPhee, J. Michael, Boulas, Pierre, Karki, Shyam B., Zawaneh, Peter N.

“…[Display omitted] Optimizing powder flow and compaction properties are critical for ensuring a robust tablet manufacturing process. The impact of flow and…”
Get full text

Reactivity of bio-coke with CO2 by NG, K. W, MACPHEE, J. A, GIROUX, L, TODOSCHUK, Ted

Get full text

Possible CO2 mitigation via addition of charcoal to coking coal blends by MACPHEE, J. A, GRANSDEN, J. F, GIROUX, L, PRICE, J. T

“…Processes involving biomass oxidation are considered to be CO2 neutral since the replenishing of the biomass by normal growth will remove CO2 from the…”
Get full text

Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection by Malgarin, Carolina M, Moser, Fiona, Pasternak, J Alex, Hamonic, Glenn, Detmer, Susan E, MacPhee, Daniel J, Harding, John C S

“…Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment…”
Get full text

Comparative analysis of porcine-uterine decellularization for bioactive-molecule preservation and DNA removal by Fazel Anvari Yazdi, Abbas, Tahermanesh, Kobra, Ejlali, Maryam, Babaei-Ghazvini, Amin, Acharya, Bishnu, Badea, Ildiko, MacPhee, Daniel J, Chen, Xiongbiao

“…Decellularized uterine extracellular matrix has emerged as a pivotal focus in the realm of biomaterials, offering a promising source in uterine tissue…”
Get full text

Enteric coating of micron-size drug particles through a Würster fluid-bed process by Leung, Cheuk-Yui, Trementozzi, Andrea N., Lin, Yiqing, Xu, Jin, Irdam, Erwin, MacPhee, J. Michael, He, Min, Karki, Shyam B., Boulas, Pierre, Zawaneh, Peter N.

“…Enteric coated active pharmaceutical ingredient (API) particles can provide advantages in clinical and pre-clinical formulation development targeting…”
Get full text

Toxicity and Efficacy of Stereotactic Ablative Body Radiotherapy for Moderately Central Non-small Cell Lung Cancers Using 50 Gy in Five Fractions by Rulach, R., McLoone, P., Lumsden, G., McKay, S., MacLaren, V., Macphee, J., Moore, K., Omand, M., Sproule, M., Currie, S., Aitken, A., Ferguson, R., Valentine, R., Houston, P., Harrow, S., Hicks, J.

“…Stereotactic ablative body radiotherapy doses for peripheral lung lesions caused high toxicity when used for central non-small cell lung cancer (NSCLC). To…”
Get full text

Application of Thermogravimetric Fourier Transform Infrared Spectroscopy (TG−FTIR) to the Analysis of Oxygen Functional Groups in Coal by Giroux, L, Charland, J.-P, MacPhee, J. A

“…This paper attempts to relate oxygen-containing gases H2O, CO2, and CO evolved during pyrolysis of the Argonne premium coals to oxygen-containing functional…”
Get full text

Fetal Metabolomic Alterations Following Porcine Reproductive and Respiratory Syndrome Virus Infection by Malgarin, Carolina M, MacPhee, Daniel J, Harding, John C S

“…PRRSV infection in third-trimester pregnant sows can lead to fetal death and abortions, although the mechanisms triggering these effects are not well…”
Get full text

Macroscopic, Histologic, and Immunomodulatory Response of Limb Wounds Following Intravenous Allogeneic Cord Blood-Derived Multipotent Mesenchymal Stromal Cell Therapy in Horses by Mund, Suzanne J K, MacPhee, Daniel J, Campbell, John, Honaramooz, Ali, Wobeser, Bruce, Barber, Spencer M

“…Limb wounds are common in horses and often develop complications. Intravenous multipotent mesenchymal stromal cell (MSC) therapy is promising but has risks…”
Get full text

Homing and Engraftment of Intravenously Administered Equine Cord Blood-Derived Multipotent Mesenchymal Stromal Cells to Surgically Created Cutaneous Wound in Horses: A Pilot Project by Mund, Suzanne J K, Kawamura, Eiko, Awang-Junaidi, Awang Hazmi, Campbell, John, Wobeser, Bruce, MacPhee, Daniel J, Honaramooz, Ali, Barber, Spencer

“…Limb wounds on horses are often slow to heal and are prone to developing exuberant granulation tissue (EGT) and close primarily through epithelialization,…”
Get full text

Subgradient Methods for Sharp Weakly Convex Functions by Davis, Damek, Drusvyatskiy, Dmitriy, MacPhee, Kellie J., Paquette, Courtney

“…Subgradient methods converge linearly on a convex function that grows sharply away from its solution set. In this work, we show that the same is true for sharp…”
Get full text

THE ENVIRONMENT CANADA PAN AND PARAPAN AMERICAN SCIENCE SHOWCASE PROJECT by Joe, P., Belair, S., Bernier, N.B., Bouchet, V., Brook, J. R., Brunet, D., Burrows, W., Charland, J.-P., Dehghan, A., Driedger, N., Duhaime, C., Evans, G., Filion, A.-B., Frenette, R., de Grandpré, J., Gultepe, I., Henderson, D., Herdt, A., Hilker, N., Huang, L., Hung, E., Isaac, G., Jeong, C.-H., Johnston, D., Klaassen, J., Leroyer, S., Lin, H., MacDonald, M., MacPhee, J., Mariani, Z., Munoz, T., Reid, J., Robichaud, A., Rochon, Y., Shairsingh, K., Sills, D., Spacek, L., Stroud, C., Su, Y., Taylor, N., Vanos, J., Voogt, J., Wang, J. M., Wiechers, T., Wren, S., Yang, H., Yip, T.

“…The Pan and Parapan American Games (PA15) are the third largest sporting event in the world and were held in Toronto in the summer of 2015 (10–26 July and 7–15…”
Get full text