Search Results - "MacPhee, Iain A. M."

Immunological risk stratification and tailored minimisation of immunosuppression in renal transplant recipients by Phanish, Mysore K, Hull, Richard P, Andrews, Peter A, Popoola, Joyce, Kingdon, Edward J, MacPhee, Iain A M

“…The efficacy and safety of minimisation of immunosuppression including early steroid withdrawal in kidney transplant recipients treated with Basiliximab…”
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Using tramadol to measure CYP2D6 metabolism in critically ill adults by Lane, Katie, Dixon, John J., McKeown, Denise, Johnston, Atholl, van Schaik, Ron H. N., van Fessem, Marianne, MacPhee, Iain A. M., Philips, Barbara J.

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CYP3A5 Genotype Had no Impact on Intrapatient Variability of Tacrolimus Clearance in Renal Transplant Recipients by SPIERINGS, N, HOLT, D. W, MACPHEE, Iain A. M

“…The risk of long-term chronic allograft nephropathy and graft loss after kidney transplantation is increased in patients with a high intrapatient variability…”
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Tacrolimus pharmacogenetics: Polymorphisms associated with expression of cytochrome P4503A5 and P-glycoprotein correlate with dose requirement by MACPHEE, Iain A. M, FREDERICKS, Salim, TAI, Tracy, SYRRIS, Petros, CARTER, Nicholas D, JOHNSTON, Atholl, GOLDBERG, Lawrence, HOLT, David W

“…There is marked heterogeneity in blood concentrations of tacrolimus following standard body-weight-based dosing. This is most apparent in black patients, who…”
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A Pharmacogenetic Strategy for Immunosuppression Based on the CYP3A5 Genotype by MACPHEE, Iain A. M, HOLT, David W

“…Pharmacogenetics has the potential to complement therapeutic drug monitoring in achieving target blood concentrations of the immunosuppressive drugs during the…”
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Use of Pharmacogenetics to Optimize Immunosuppressive Therapy by MACPHEE, Iain A. M

“…Pharmacogenetic strategies offer promise as an adjunct to therapeutic drug monitoring in achieving target blood concentrations of the immunosuppressive drugs…”
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Polymorphisms in CYP3A5, CYP3A4, and ABCB1 are Not Associated With Cyclosporine Pharmacokinetics Nor With Cyclosporine Clinical End Points After Renal Transplantation by BOUAMAR, Rachida, HESSELINK, Dennis A, VAN SCHAIK, Ron H. N, WEIMAR, Willem, MACPHEE, Iain A. M, DE FIJTER, Johan W, VAN GELDER, Teun

“…The association of CYP3A5, CYP3A4, and ABCB1 single nucleotide polymorphisms (SNPs) with cyclosporine (CsA) pharmacokinetics is controversial. The authors…”
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Multidrug resistance gene-1 (MDR-1) haplotypes have a minor influence on tacrolimus dose requirements by FREDERICKS, Salim, MORETON, Michelle, REBOUX, Sandrine, CARTER, Nicholas D, GOLDBERG, Lawrence, HOLT, David W, MACPHEE, Iain A. M

“…P-glycoprotein (P-gp) and the drug metabolizing enzymes have major pharmacokinetic effects. Variability in tacrolimus absorption is influenced by P-gp activity…”
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Black renal transplant recipients have poorer long-term graft survival than CYP3A5 expressers from other ethnic groups by Ng, Fu Liang, Holt, David W., Chang, Rene W. S., MacPhee, Iain A. M.

“…Background. African American transplant recipients have poorer long-term outcomes than Caucasian Americans. This difference was not found in French patients,…”
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Using midazolam to monitor changes in hepatic drug metabolism in critically ill patients by Kirwan, Christopher John, Lee, Terry, Holt, David W., Grounds, R. Michael, MacPhee, Iain A. M., Philips, Barbara J.

“…Objective Critical illness and associated sequelae can cause severe metabolic disturbances. The effects these have on hepatic drug metabolism are poorly…”
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Validation of a continuous infusion of low dose Iohexol to measure glomerular filtration rate: randomised clinical trial by Dixon, John J, Lane, Katie, Dalton, R Neil, Turner, Charles, Grounds, R Michael, MacPhee, Iain A M, Philips, Barbara J

“…There is currently no accurate method of measuring glomerular filtration rate (GFR) during acute kidney injury (AKI). Knowledge of how much GFR varies in…”
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Estimated Glomerular Filtration Rate Correlates Poorly with Four-Hour Creatinine Clearance in Critically Ill Patients with Acute Kidney Injury by Kirwan, Christopher J., Philips, Barbara J., MacPhee, Iain A. M.

“…Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts…”
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BK Virus Nephropathy in Renal Transplant Patients in London by WHITE, Laura H, CASIAN, Alina, HILTON, Rachel, MACPHEE, Iain A. M, MARSH, James, SWENY, Paul, TREVITT, Ray, FRANKEL, Andrew H, WARRENS, Anthony N

“…BK nephropathy (BKN) is an important cause of renal transplant dysfunction, believed to be associated with higher levels of immunosuppression. We assessed the…”
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Measured Versus Estimated Glomerular Filtration Rate in the Assessment of Living Kidney Donors: eGFR Has Its Limitations by MacPhee, Iain A M

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Renohepatic crosstalk: does acute kidney injury cause liver dysfunction? by Lane, Katie, Dixon, John J, MacPhee, Iain A M, Philips, Barbara J

“…The concept of hepatorenal syndrome is well recognized, although incompletely understood. The converse clinical problem of hepatic dysfunction in patients with…”
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Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A51 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements by Fredericks, Salim, Jorga, AnaMaria, MacPhee, Iain A.M., Reboux, Sandrine, Shiferaw, Elizabeth, Moreton, Michelle, Carter, Nicholas D., Holt, David W., Johnston, Atholl

“…:  The intestinal efflux pump P‐glycoprotein (P‐gp), the product of the multi‐drug resistance‐1 (MDR‐1) gene, significantly influences the pharmacokinetics of…”
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Pharmacogenetic biomarkers: cytochrome P450 3A5 by MacPhee, Iain A.M.

“…The immunosuppressive drugs used for solid organ transplantation all have a narrow therapeutic index with wide variation between individuals in the blood…”
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Continuous Infusion of Low-Dose Iohexol Measures Changing Glomerular Filtration Rate in Critically Ill Patients by Dixon, John J, Lane, Katie, Dalton, R Neil, Turner, Charles, MacPhee, Iain A M, Chis Ster, Irina, Philips, Barbara J

“…OBJECTIVE:Measurement of changing glomerular filtration rate in acute kidney injury remains problematic. We have previously used a continuous infusion of…”
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A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients by Boughton, Oliver, Borgulya, Gabor, Cecconi, Maurizio, Fredericks, Salim, Moreton‐Clack, Michelle, MacPhee, Iain A. M.

“…Aims An algorithm based on the CYP3A5 genotype to predict tacrolimus clearance to inform the optimal initial dose was derived using data from the DeKAF study…”
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A renal registry for Africa: first steps by Davids, M. Razeen, Eastwood, John B., Selwood, Neville H., Arogundade, Fatiu A., Ashuntantang, Gloria, Benghanem Gharbi, Mohammed, Jarraya, Faiçal, MacPhee, Iain A.M., McCulloch, Mignon, Plange-Rhule, Jacob, Swanepoel, Charles R., Adu, Dwomoa

“…There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable…”
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