Search Results - "MacPhail, A P"

Associations of Iron Overload in Africa With Hepatocellular Carcinoma and Tuberculosis: Strachan's 1929 Thesis Revisited by Gordeuk, V.R., McLaren, C.E., MacPhail, A.P., Deichsel, G., Bothwell, T.H.

“…We analyzed data from the first study of iron overload in Africans, conducted between 1925 and 1928, to determine whether this common condition is associated…”
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Hereditary hemochromatosis: etiologic, pathologic, and clinical aspects by Bothwell, T H, MacPhail, A P

“…The human leukocyte antigen (HLA)-linked iron-loading gene (HFE) associated with the autosomal recessive disorder known as hereditary hemochromatosis occurs in…”
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Dietary iron overload as a risk factor for hepatocellular carcinoma in black africans by Mandishona, Eberhard, MacPhail, A. Patrick, Gordeuk, Victor R., Kedda, Mary‐Anne, Paterson, Alan C., Rouault, Tracey A., Kew, Michael C.

“…Although the iron‐loading disease, hereditary hemochromatosis, has a strong causal association with hepatocellular carcinoma (HCC), the carcinogenic potential…”
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Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene? by MCNAMARA, L, MACPHAIL, A. P, GORDEUK, V. R, HASSTEDT, S. J, ROUAULT, T

“…Over 80% of Caucasian patients with hereditary haemochromatosis are homozygotes for a C282Y mutation in the HFE gene on chromosome 6. Recent evidence suggests…”
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Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black African patients with hip fractures--a bone histomorphometric study by Schnitzler, C M, Schnaid, E, MacPhail, A P, Mesquita, J M, Robson, H J

“…Osteoporosis and femoral neck fractures (FNF) are uncommon in black Africans although osteoporosis accompanying iron overload (from traditional beer brewed in…”
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Evidence of Genetic Transmission in African Iron Overload by Moyo, Victor M., Mandishona, Eberhard, Hasstedt, Sandra J., Gangaidzo, Innocent T., Gomo, Zvenyika A.R., Khumalo, Hlosukwazi, Saungweme, Thokozile, Kiire, Clement F., Paterson, Alan C., Bloom, Peter, Patrick MacPhail, A., Rouault, Tracey, Gordeuk, Victor R.

“…Iron overload in Africa was previously regarded as purely due to excessive iron in traditional beer, but we recently found evidence that transferrin saturation…”
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Clinical and genetic heterogeneity in hereditary haemochromatosis: association between lymphocyte counts and expression of iron overload by Porto, Graça, Cardoso, Carla S., Gordeuk, Victor, Cruz, Eugénia, Fraga, José, Areias, Jorge, Oliveira, José Carlos, Bravo, Fernanda, Gangaidzo, Innocent T., MacPhail, A.P., Gomo, Zvenyika A.R., Moyo, Victor M., Melo, Graça, Silva, Cidália, Justiça, Benvindo, De Sousa, Maria

“…: To identify a new marker of expression of disease, independent of HFE genotype in patients with hereditary haemochromatosis (HHC), the total peripheral blood…”
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Nutritional iron requirements and food iron absorption by Bothwell, T H, Baynes, R D, MacFarlane, B J, MacPhail, A P

“…To prevent nutritional iron deficiency, sufficient iron must be absorbed from the diet to meet the normal physiological requirements. Daily iron losses in…”
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traditional beverage prevents iron deficiency in African women of child bearing age by Mandishona, E.M, Moyo, V.M, Gordeuk, V.R, Khumalo, H, Saungweme, T, Gangaidzo, I.T, Gomo, Z.A.R, Rouault, T, MacPhail, A.P

“…Objective: To determine if a traditional item in the diet might be useful in preventing iron deficiency in African women of child-bearing age. Design: In a…”
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Geographic Variation in the Humoral Response to Pneumocystis carinii by Smulian, A. G., Sullivan, D. W., Linke, M. J., Halsey, N. A., Quinn, T. C., MacPhail, A. P., Avila, M. A. Hernandez, Hong, S. T., Walzer, P. D.

“…The reported incidence of Pneumocystis carinii pneumonia varies in different areas of the world, but little is known about geographic variation in the antibody…”
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The effects of organic acids, phytates and polyphenols on the absorption of iron from vegetables by Gillooly, M., Bothwell, T. H., Torrance, J. D., MacPhail, A. P., Derman, D. P., Bezwoda, W. R., Mills, W., Charlton, R. W., Mayet, Fatima

“…1. Non-haem iron absorption from a variety of vegetable meals was studied in parous Indian Women, using the erythrocyte utilization of radioactive Fe method…”
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The effects of fruit juices and fruits on the absorption of iron from a rice meal by Ballot, D., Baynes, R. D., Bothwell, T. H., Gillooly, M., Macfarlane, J., Macphail, A. P., Lyons, G., Derman, D. P., Bezwoda, W. R., Torrance, J. D., Bothwell, J. E.

“…1. The effects of the chemical composition of fruit juices and fruit on the absorption of iron from a rice (Oryza sativa) meal were measured in 234 parous…”
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EDTA and the absorption of iron from food by MacPhail, AP, Patel, RC, Bothwell, TH, Lamparelli, RD

“…Iron EDTA is an effective fortificant in meals of low iron bioavailability. Na2EDTA, added to food to prevent oxidation, enhances iron bioavailability by…”
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Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload by Mcnamara, Lynne, Macphail, A, Mandishona, Eberhard, Bloom, Peter, Paterson, Alan, Rouault, Tracey, Gordeuk, Victor

“…Background: Circulating iron is normally bound to transferrin. Non‐transferrin‐bound iron (NTBI) has been described in most forms of iron overload, but has not…”
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Fortification of curry powder with NaFe(111)EDTA in an iron-deficient population: report of a controlled iron-fortification trial by Ballot, D E, MacPhail, A P, Bothwell, T H, Gillooly, M, Mayet, F G

“…A targeted, double-blind controlled iron fortification trial using Fe(111)-EDTA in masala (curry powder) was directed towards an Fe-deficient Indian population…”
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Transferrin Saturation, Plasma Iron Turnover, and Transferrin Uptake in Normal Humans by Cazzola, Mario, Huebers, Helmut A., Sayers, Merlin H., MacPhail, A. Patrick, Eng, Mary, Finch, Clement A.

“…The relationship between plasma iron, transferrin saturation, and plasma iron turnover was studied in 53 normal subjects whose transferrin saturation varied…”
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A prospective study of iron status in white and black pregnant women in an urban hospital by GUIDOZZI, F, PATEL, R, MACPHAIL, A. P

“…Evaluation of the iron status (haemoglobin and ferritin concentrations, and percentage transferrin saturation) in a prospective study of 65 pregnant women (55…”
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The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status by Malope, Babatyi I., MacPhail, A. Patrick, Alberts, Marianne, Hiss, Donavon C.

“…Laboratory tests used in the diagnosis of iron status lack specificity in defining iron deficiency anaemia (IDA) and anaemia of inflammation (AI). The serum…”
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Osteoporosis in african hemosiderosis: Role of alcohol and iron by Schnitzler, Christine M., Macphail, A. Patrick, Shires, Roy, Schnaid, Edward, Mesquita, Julia M., Robson, Heather J.

“…This paper aims to examine the relative contributions made by alcohol and iron overload and hypovitaminosis C to the osteoporosis associated with African…”
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Measurements of iron status and survival in African iron overload by MACPHAIL, A. P, MANDISHONA, E. M, BLOOM, P. D, PATERSON, A. C, ROUAULT, T. A, GORDEUK, V. R

“…Dietary iron overload is common in southern Africa and there is a misconception that the condition is benign. Early descriptions of the condition relied on…”
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