Search Results - "MacNeill, Joan"

Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases by Moritz, Albrecht, Li, Yu, Guo, Ailan, Villén, Judit, Wang, Yi, MacNeill, Joan, Kornhauser, Jon, Sprott, Kam, Zhou, Jing, Possemato, Anthony, Ren, Jian Min, Hornbeck, Peter, Cantley, Lewis C, Gygi, Steven P, Rush, John, Comb, Michael J

“…Receptor tyrosine kinases (RTKs) activate pathways mediated by serine-threonine kinases, such as the PI3K (phosphatidylinositol 3-kinase)-Akt pathway, the…”
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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer by Rikova, Klarisa, Guo, Ailan, Zeng, Qingfu, Possemato, Anthony, Yu, Jian, Haack, Herbert, Nardone, Julie, Lee, Kimberly, Reeves, Cynthia, Li, Yu, Hu, Yerong, Tan, Zhiping, Stokes, Matthew, Sullivan, Laura, Mitchell, Jeffrey, Wetzel, Randy, MacNeill, Joan, Ren, Jian Min, Yuan, Jin, Bakalarski, Corey E., Villen, Judit, Kornhauser, Jon M., Smith, Bradley, Li, Daiqiang, Zhou, Xinmin, Gygi, Steven P., Gu, Ting-Lei, Polakiewicz, Roberto D., Rush, John, Comb, Michael J.

“…Despite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our…”
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Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma by Gu, Ting-Lei, Deng, Xiaxing, Huang, Feizhou, Tucker, Meghan, Crosby, Katherine, Rimkunas, Victoria, Wang, Yi, Deng, Gang, Zhu, Lei, Tan, Zhiping, Hu, Yerong, Wu, Chunlin, Nardone, Julie, MacNeill, Joan, Ren, Jianmin, Reeves, Cynthia, Innocenti, Gregory, Norris, Brett, Yuan, Jin, Yu, Jian, Haack, Herbert, Shen, Baiyong, Peng, Chenghong, Li, Hongwei, Zhou, Xinmin, Liu, Xunyang, Rush, John, Comb, Michael J

“…Cholangiocarcinoma, also known as bile duct cancer, is the second most common primary hepatic carcinoma with a median survival of less than 2 years. The…”
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Signaling networks assembled by oncogenic EGFR and c-Met by Guo, Ailan, Villén, Judit, Kornhauser, Jon, Lee, Kimberly A, Stokes, Matthew P, Rikova, Klarisa, Possemato, Anthony, Nardone, Julie, Innocenti, Gregory, Wetzel, Randall, Wang, Yi, MacNeill, Joan, Mitchell, Jeffrey, Gygi, Steven P, Rush, John, Polakiewicz, Roberto D, Comb, Michael J

“…A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that…”
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Profiling of UV-induced ATM/ATR signaling pathways by Stokes, Matthew P, Rush, John, MacNeill, Joan, Ren, Jian Min, Sprott, Kam, Nardone, Julie, Yang, Vicky, Beausoleil, Sean A, Gygi, Steven P, Livingstone, Mark, Zhang, Hui, Polakiewicz, Roberto D, Comb, Michael J

“…To ensure survival in the face of genomic insult, cells have evolved complex mechanisms to respond to DNA damage, termed the DNA damage checkpoint. The…”
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Survey of activated FLT3 signaling in leukemia by Gu, Ting-lei, Nardone, Julie, Wang, Yi, Loriaux, Marc, Villén, Judit, Beausoleil, Sean, Tucker, Meghan, Kornhauser, Jon, Ren, Jianmin, MacNeill, Joan, Gygi, Steven P, Druker, Brian J, Heinrich, Michael C, Rush, John, Polakiewicz, Roberto D

“…Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an…”
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A common phosphotyrosine signature for the Bcr-Abl kinase by Goss, Valerie L., Lee, Kimberly A., Moritz, Albrecht, Nardone, Julie, Spek, Erik J., MacNeill, Joan, Rush, John, Comb, Michael J., Polakiewicz, Roberto D.

“…The Bcr-Abl fusion kinase drives oncogenesis in chronic myeloid leukemia (CML). CML patients are currently treated with the Abl tyrosine kinase inhibitor…”
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Abstract A94: Understanding of differing sensitivity in EML4-ALK NSCLC patients to crizotinib and geldanamycin by Rikova, Klarisa, Hall, Benjamin, Possemato, Anthony, Mroszczyk, Keri, Lee, Kimberly A., MacNeill, Joan, Ren, Jian Min, Guo, Ailan, Mulhern, Daniel, Wang, Yi, Beausoleil, Sean A., Comb, Michael J.

“…Abstract Non-small cell lung cancer (NSCLC) is the most common form of lung cancer, afflicting nearly 200,000 people in the United States each year. Abnormal…”
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Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia by Gu, Ting-Lei, Goss, Valerie L., Reeves, Cynthia, Popova, Lana, Nardone, Julie, MacNeill, Joan, Walters, Denise K., Wang, Yi, Rush, John, Comb, Michael J., Druker, Brian J., Polakiewicz, Roberto D.

“…The 8p11 myeloproliferative syndrome (EMS) is associated with translocations that disrupt the FGFR1 gene. To date, 8 fusion partners of FGFR1 have been…”
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Profiling of UV-induccd ATM/ATR signaling pathways by Stokes, Matthew P, Rush, John, MacNeill, Joan, Ren, Jian Min, Sprott, Kam, Nardone, Julie, Yang, Vicky, Beausoleil, Sean A, Gygi, Steven P, Livingstone, Mark, Zhang, Hui, Polakiewicz, Roberto D, Comb, Michael J

“…To ensure survival in the face of genomic insult, cells have evolved complex mechanisms to respond to DNA damage, termed the DNA damage checkpoint. The…”
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A common dhosphotyrosine signature for the Bcr-Ab1 kinase by GOSS, Valerie L, LEE, Kimberly A, MORITZ, Albrecht, NARDONE, Julie, SPEK, Erik J, MACNEILL, Joan, RUSH, John, COMB, Michael J, POLAKIEWICZ, Roberto D

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PNA solubility enhancers by Gildea, Brian D., Casey, Shelagh, MacNeill, Joan, Perry-O'Keefe, Heather, Sørensen, Ditte, Coull, James M.

“…Fmoc-protected hydrophilic amino acids were prepared and incorporated into peptide nucleic acid (PNA). N- and C-terminal modification of PNA did not affect its…”
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