Search Results - "MacNeil, I"

Cloning the Soil Metagenome: a Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganisms by RONDON, M. R, AUGUST, P. R, CHOI LAI TIONG, GILMAN, M, OSBURNE, M. S, CLARDY, J, HANDELSMAN, J, GOODMAN, R. M, BETTERMANN, A. D, BRADY, S. F, GROSSMAN, T. H, LILES, M. R, LOIACONO, K. A, LYNCH, B. A, MACNEIL, I. A, MINOR, C

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70 by Vu, Chi B, Corpuz, Evelyn G, Merry, Taylor J, Pradeepan, Selvaluxmi G, Bartlett, Catherine, Bohacek, Regine S, Botfield, Martyn C, Eyermann, Charles J, Lynch, Berkley A, MacNeil, Ian A, Ram, Mary K, van Schravendijk, Marie Rose, Violette, Shelia, Sawyer, Tomi K

“…A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target…”
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Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction by Zoller, KE, MacNeil, IA, Brugge, JS

“…Engagement of immunoreceptors in hemopoietic cells leads to activation of Src family tyrosine kinases as well as Syk or ZAP-70. Current models propose that Src…”
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Structure-activity relationships of a novel class of Src SH2 inhibitors by Buchanan, John L., Vu, Chi B., Merry, Taylor J., Corpuz, Evelyn G., Pradeepan, Selvaluxmi G., Mani, Ukti N., Yang, Michael, Plake, Hilary R., Varkhedkar, Vaibhav M., Lynch, Berkley A., MacNeil, Ian A., Loiacono, Kara A., Tiong, Choi Lai, Holt, Dennis A.

“…The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4-…”
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IL-10, a novel growth cofactor for mature and immature T cells by MacNeil, IA, Suda, T, Moore, KW, Mosmann, TR, Zlotnik, A

“…We identified a new cytokine, B cell-derived T cell growth factor (B-TCGF), that is produced by a murine B cell lymphoma and induces proliferation of mature…”
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Expression and isolation of antimicrobial small molecules from soil DNA libraries by MacNeil, I A, Tiong, C L, Minor, C, August, P R, Grossman, T H, Loiacono, K A, Lynch, B A, Phillips, T, Narula, S, Sundaramoorthi, R, Tyler, A, Aldredge, T, Long, H, Gilman, M, Holt, D, Osburne, M S

“…Natural products have been a critically important source of clinically relevant small molecule therapeutics. However, the discovery rate of novel structural…”
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Abstract P4-12-06: Quantification of HER2-driven signaling (HER2S) inhibition of four different anti-HER2 drugs tested ex vivo in live primary HER2-negative breast cancer cell samples with abnormal HER2 signaling activity by Laing, L, Burns, D, Huang, Y, MacNeil, I, Rich, B, Myhre, S, Soltani, S, Sullivan, B

“…Background: A new functional cellular analysis platform, the CELx HER2 Signaling Profile (CELx HSP) Test, uses a label-free impedance biosensor to measure HER2…”
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Abstract P6-07-14: New method to measure functional HER2-driven signaling activity in primary tumor cells identifies HER2-negative breast cancers with abnormal HER2 signaling activity: New group of patients may benefit from anti-HER2 therapy by Laing, L, Burns, D, MacNeil, I, Rich, B, Huang, Y, Myhre, S, Soltani, S, Sullivan, B

“…Background: Clinical trials have indicated a weak correlation between HER2 expression levels and HER2 targeted therapy benefit. Other biological factors, such…”
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A Fluorescence Polarization Based Src-SH2 Binding Assay by Lynch, Berkley A., Loiacono, Kara A., Tiong, Choi Lai, Adams, Susan E., MacNeil, Ian A.

“…The tyrosine kinase pp60c-srchas been implicated as being a potential therapeutic target in several human diseases including cancer and osteoporosis. An…”
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Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum by August, P R, Grossman, T H, Minor, C, Draper, M P, MacNeil, I A, Pemberton, J M, Call, K M, Holt, D, Osburne, M S

“…Violacein is a purple-colored, broad-spectrum antibacterial pigment that has a dimeric structure composed of 5-hydroxyindole, oxindole and 2-pyyrolidone…”
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Activism and collaboration among shareholders in UK listed companies by MacNeil, I.

“…The new Stewardship Code published by the Financial Reporting Council in July 2010 supersedes the Code developed by the Institutional Shareholders Committee…”
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Excision-amplification of mitochondrial DNA during senescence in Podospora anserina. DNA sequence analysis of three unique "plasmids" by Cummings, D J, MacNeil, I A, Domenico, J, Matsuura, E T

“…During senescence in the filamentous fungus Podospora anserina, specific regions of the mitochondrial genome, termed senDNA are excised, ligated and amplified…”
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A simple test for stable seasonality by Sutradhar, B.C., MacNeil, I.B., Dagum, E.B.

“…The adjustment of economic and social time series for seasonal variation has been and continues to be the subject of much attention. As a first step towards…”
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Simultaneous Assay of Src SH3 and SH2 Domain Binding Using Different Wavelength Fluorescence Polarization Probes by Lynch, Berkley A., Minor, Charles, Loiacono, Kara A., van Schravendijk, Marie Rose, Ram, Mary K., Sundaramoorthi, Raji, Adams, Susan E., Phillips, Tom, Holt, Dennis, Rickles, Richard J., MacNeil, Ian A.

“…pp60c-src is a prototypical nonreceptor tyrosine kinase and may play a role in diseases as diverse as cancer and osteoporosis. In Src, the SH3 domain (Src…”
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Private equity: the UK regulatory response by MacNeil, Iain

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The evolution of regulatory enforcement action in the UK capital markets: a case of 'less is more'? by MacNeil, Iain

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Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit by Helaakoski, T, Annunen, P, Vuori, K, MacNeil, I A, Pihlajaniemi, T, Kivirikko, K I

“…Prolyl 4-hydroxylase (EC 1.14.11.2) catalyzes the posttranslational formation of 4-hydroxyproline in collagens. The vertebrate enzyme is an alpha 2 beta 2…”
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Contracting Worlds: The Many Autonomies of Private Law by Teubner, Gunther

“…Locates contract in the development of a world economy where the cash nexus, mediated by law, predominates. Neoliberal capitalism has produced the 'sanctimony…”
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Abstract P2-09-22: Use of a functional signal profiling test with high sensitivity and specificity to determine the prevalence of abnormal HER2-driven signaling activity in the HER2-negative breast cancer patient population: New patient group may benefit from HER2 therapy by Laing, LG, Burns, DJ, MacNeil, IA, Rich, BE, Myhre, S, Soltani, S, Sullivan, BF

“…Background: Biological factors, such as HER2 signaling activity, may be important to measure in addition to expression and amplification of HER2 when…”
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A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells by Ikuta, K, Kina, T, MacNeil, I, Uchida, N, Peault, B, Chien, Y H, Weissman, I L

“…Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in…”
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