Search Results - "MacNee, W."

Oxidative stress and regulation of glutathione in lung inflammation by Rahman, I, MacNee, W

“…Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance, a major cause of cell damage. The development of an…”
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Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) by Vestbo, J, Anderson, W, Coxson, H. O, Crim, C, Dawber, F, Edwards, L, Hagan, G, Knobil, K, Lomas, D. A, MacNee, W, Silverman, E. K, Tal-Singer, R, on behalf of ECLIPSE investigators

“…Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and not well understood. The forced expiratory volume in one second is used for the…”
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Premature vascular ageing in cystic fibrosis by Macnee, W

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Size-Dependent Proinflammatory Effects of Ultrafine Polystyrene Particles: A Role for Surface Area and Oxidative Stress in the Enhanced Activity of Ultrafines by Brown, D.M., Wilson, M.R., MacNee, W., Stone, V., Donaldson, K.

“…Studies into the effects of ultrafine particles in the lung have shown adverse effects considered to be due in part to the particle size. Air pollution…”
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NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis by CHO, W.-S, DUFFIN, R, BRADLEY, M, MEGSON, I. L, MACNEE, W, HOWIE, S. E. M, DONALDSON, K

“…Lung exposure to metal oxide nanoparticles (NPs) comprising soluble metal haptens may produce T-helper cell type 1 (Th1)- and Th17-associated delayed-type…”
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Telomere shortening in smokers with and without COPD by Morla, M, Busquets, X, Pons, J, Sauleda, J, MacNee, W, Agusti, A. G. N

“…Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes. Telomere length shortens with age in all replicating somatic cells…”
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Hypothesis: Does COPD have an autoimmune component? by Agustí, A, MacNee, W, Donaldson, K, Cosio, M

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Ambient Particle Inhalation and the Cardiovascular System: Potential Mechanisms by Donaldson, Ken, Stone, Vicki, Seaton, Anthony, MacNee, William

“…Well-documented air pollution episodes throughout recent history have led to deaths among individuals with cardiovascular and respiratory disease. Although the…”
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Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part One by MacNee, W

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Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper by CELLI, B. R, MACNEE, W

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Role of transcription factors in inflammatory lung diseases by Rahman, Irfan, MacNee, William

“…4 Other transcription factors include the nuclear factor for the IL-1 responsive element in the IL-6 gene (NF-IL6), nuclear factor of activated T cells (NFAT),…”
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Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk by Mills, N L, Miller, J J, Anand, A, Robinson, S D, Frazer, G A, Anderson, D, Breen, L, Wilkinson, I B, McEniery, C M, Donaldson, K, Newby, D E, Macnee, W

“…Chronic obstructive pulmonary disease (COPD) is associated with a 2-3-fold increase in the risk of ischaemic heart disease, stroke and sudden death. The…”
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Oxidative stress and airway inflammation in severe exacerbations of COPD by Drost, E M, Skwarski, K M, Sauleda, J, Soler, N, Roca, J, Agusti, A, MacNee, W

“…Background: A study was undertaken to assess both oxidative stress and inflammation in the lungs of patients with chronic obstructive pulmonary disease (COPD)…”
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The potential impact of anaemia of chronic disease in COPD by Similowski, T, Agusti, A, MacNee, W, Schonhofer, B

“…Anaemia of chronic disease (ACD), with chronically low levels of circulating haemoglobin, is an immune driven abnormality that occurs in many inflammatory…”
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Ultrafine particles by Donaldson, K, Stone, V, Clouter, A, Renwick, L, MacNee, W

“…The lungs of susceptible people may be in some way primed-for example, by the presence of inflammation-to hyperrespond in a way that normal lungs do not…”
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COPD — Comorbidities by MacNee, W

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Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways by Mroz, R. M, Schins, R. P. F, Li, H, Jimenez, L. A, Drost, E. M, Holownia, A, MacNee, W, Donaldson, K

“…The epidemiological association between cancer and exposure to ambient air pollution particles (particles with a 50% cut-off aerodynamic diameter of 10 microm…”
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A review of the most common patient-reported outcomes in COPD--revisiting current knowledge and estimating future challenges by Cazzola, Mario, Hanania, Nicola Alexander, MacNee, William, Rüdell, Katja, Hackford, Claire, Tamimi, Nihad

“…Patient-reported outcome (PRO) measures that quantify disease impact have become important measures of outcome in COPD research and treatment. The objective of…”
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Particulate air pollution and acute health effects by Seaton, A, MacNee, W, Donaldson, K, Godden, D

“…Epidemiological studies have consistently shown an association between particulate air pollution and not only exacerbations of illness in people with…”
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Computed tomographic emphysema distribution: relationship to clinical features in a cohort of smokers by Mair, G, Miller, J. J, McAllister, D, Maclay, J, Connell, M, Murchison, J. T, MacNee, W

“…Computed tomography (CT) scanning allows precise assessment of both the extent and distribution of emphysema. There has been little work on the relationship…”
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