Search Results - "MacNaughton, W. K."

Submucosal secretomotor and vasodilator reflexes by Vanner, S., Macnaughton, W. K.

“…The presence of neuronal reflexes within the intestine that modulate mucosal ion secretion and blood flow have been recognized for many years, but the…”
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Review article: new insights into the pathogenesis of radiation‐induced intestinal dysfunction by MACNAUGHTON, W. K

“…Exposure of the abdomino‐pelvic region to ionizing radiation, such as that received during radiotherapy, is associated with the development of a number of…”
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Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction by Zamuner, S R, Warrier, N, Buret, A G, MacNaughton, W K, Wallace, J L

“…Background and aims: The colonic epithelium plays a key role in host defence. During colitis, epithelial function is impaired, leading to elevated bacterial…”
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Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity by Wallace, John L., Bak ‡, Adrian, McKnight, Webb, Asfaha, Samuel, Sharkey §, Keith A., MacNaughton §, Wallace K.

“…Background & Aims: Selective inhibitors of cyclooxygenase (COX)-2 are being developed as gastrointestinal-sparing anti-inflammatory drugs based on the premise…”
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Attenuation of Clostridium difficile toxin‐induced damage to epithelial barrier by ecto‐5′‐nucleotidase (CD73) and adenosine receptor signaling by Patrick Schenck, L., Hirota, S. A., Hirota, C. L., Boasquevisque, P., Tulk, S. E., Li, Y., Wadhwani, A., Doktorchik, C. T. A., MacNaughton, W. K., Beck, P. L., MacDonald, J. A.

“…Background Clostridium difficile (Cdf) releases toxins (TcdA and TcdB) that damage the intestinal epithelial barrier. Ecto‐5′‐nucleotidase (CD73) is expressed…”
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GLP-2 augments the adaptive response to massive intestinal resection in rat by Scott, R B, Kirk, D, MacNaughton, W K, Meddings, J B

“…To determine whether treatment with a potent protease-resistant analog of human glucagon-like peptide 2 (GLP-2) might augment the adaptive response to massive…”
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Aspirin causes rapid up‐regulation of cyclo‐oxygenase‐2 expression in the stomach of rats by DAVIES, N. M., SHARKEY, K. A., ASFAHA, S., MACNAUGHTON, W. K., WALLACE, J. L.

“…Background: Cyclo‐oxygenase‐1 (COX‐1) is believed to produce prostaglandins vital to mucosal defence, whereas cyclo‐oxygenase‐2 (COX‐2) is induced at sites of…”
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Nitric oxide inhibitable isoforms of adenylate cyclase mediate epithelial secretory dysfunction following exposure to ionising radiation by Freeman, S L, MacNaughton, W K

“…Background: Hyporesponsiveness of the intestinal epithelium to secretagogues occurs in different models of intestinal injury, including radiation enteropathy,…”
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Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis, Crohn's disease and infectious colitis by Hardin, J A, Wallace, L E, Wong, J F K, O'Loughlin, E V, Urbanski, S J, Gall, D G, MacNaughton, W K, Beck, P L

“…Colitis is associated with alterations in electrolyte and water transport. These changes give rise to some of the symptoms experienced by patients with…”
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Expression, activity and cellular localization of inducible nitric oxide synthase in rat ileum and colon post-irradiation by MACNAUGHTON, W. K.

“…Purpose: Studies were conducted to determine the acute effect of exposure to ionizing radiation on inducible nitric oxide synthase (iNOS) activity and…”
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Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation by Asfaha, S, MacNaughton, W K, Appleyard, C B, Chadee, K, Wallace, J L

“…Epithelial secretion may play an important role in reducing bacterial colonization and translocation in intestine. If so, secretory dysfunction could result in…”
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Capsaicin-sensitive afferent nerves activate submucosal secretomotor neurons in guinea pig ileum by Vanner, S, MacNaughton, W K

“…This study examined whether capsaicin-sensitive sensory nerves regulate intestinal ion transport using both Ussing chamber and intracellular recording…”
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Radiation-induced acute intestinal inflammation differs following total-body versus abdominopelvic irradiation in the ferret by FREEMAN, S. L, HOSSAIN, M, MACNAUGHTON, W. K

“…Purpose : The studies were designed to investigate the differences in the intestinal inflammatory response following abdominopelvic or total-body irradiation…”
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Nitric oxide-donating compounds stimulate electrolyte transport in the guinea pig intestine in vitro by MacNaughton, W K

“…The role of nitric oxide (NO) as a regulator of intestinal electrolyte transport was investigated in stripped segments of guinea pig intestine mounted in…”
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Exposure to ionizing radiation modifies neurally-evoked electrolyte transport and some inflammatory responses in rat colon in vitro by FRANCOIS, A., AIGUEPERSE, J, GOURMELON, P, MACNAUGHTON, W. K., GRIFFITHS, N. M.

“…Purpose: To characterize the responsiveness of the colon to neural stimulation following acute exposure of rats to gamma -radiation and to correlate observed…”
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The expression and role of Fas ligand in intestinal inflammation by Sayani, F. A., Keenan, C. M., Van Sickle, M. D., Amundson, K. R., Parr, E. J., Mathison, R. D., MacNaughton, W. K., Braun, J. E. A., Sharkey, K. A.

“…Fas ligand (FasL) is involved in the pathogenesis of inflammatory diseases and immune privilege. We examined the expression of FasL in the enteric nervous…”
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Differential effects of salvinorin A on endotoxin‐induced hypermotility and neurogenic ion transport in mouse ileum by Fichna, J., Dicay, M., Hirota, S. A., Traboulsi, D., MacDonald, J. A., Janecka, A., Beck, P. L., Zjawiony, J. K., MacNaughton, W. K., Storr, M. A.

“…Background  Salvinorin A (SA) is the principal active ingredient of Salvia divinorum, with an established inhibitory action on gastrointestinal (GI) transit…”
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Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach by MacNaughton, W K, Cirino, G, Wallace, J L

“…The role that nitric oxide, an endothelium-derived relaxing factor, may play in the regulation of gastric mucosal defence was investigated by assessing the…”
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Strain-Dependent Induction of Enterocyte Apoptosis by Giardia lamblia Disrupts Epithelial Barrier Function in a Caspase-3-Dependent Manner by CHIN, Alex C, TEOH, Desiree A, SCOTT, Kevin G.-E, MEDDINGS, Jonathon B, MACNAUGHTON, Wallace K, BURET, Andre G

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Adaptation of intestinal secretomotor function and nutrient absorption in response to diet‐induced obesity by Hyland, N. P., Rybicka, J. M., Ho, W., Pittman, Q. J., Macnaughton, W. K., Sharkey, K. A.

“…Background  The gut plays a significant role in the development of obesity, notably through peptide signaling to the brain. However, few studies have…”
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