Search Results - "MacMillan, Derek"

Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity by Zhu, Yanan, PhD, Underwood, Joanne, PhD, Macmillan, Derek, PhD, Shariff, Leila, PhD, O'Shaughnessy, Ryan, PhD, Harper, John I., MD, FRCP, FRCPCH, Pickard, Chris, PhD, Friedmann, Peter S., MD, FRCP, FMedSci, Healy, Eugene, MB, PhD, FRCP, FRSB, Di, Wei-Li, MBBS, PhD

“…Background Upregulation of kallikreins (KLKs) including KLK5 has been reported in atopic dermatitis (AD). KLK5 has biological functions that include degrading…”
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The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus by Currie, Silke M, Findlay, Emily Gwyer, McHugh, Brian J, Mackellar, Annie, Man, Tian, Macmillan, Derek, Wang, Hongwei, Fitch, Paul M, Schwarze, Jürgen, Davidson, Donald J

“…Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently,…”
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Tissue Kallikrein Inhibitors Based on the Sunflower Trypsin Inhibitor Scaffold - A Potential Therapeutic Intervention for Skin Diseases by Chen, Wenjie, Kinsler, Veronica A, Macmillan, Derek, Di, Wei-Li

“…Tissue kallikreins (KLKs), in particular KLK5, 7 and 14 are the major serine proteases in the skin responsible for skin shedding and activation of inflammatory…”
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Investigation of peptide thioester formation via N→Se acyl transfer by Adams, Anna L., Macmillan, Derek

“…Native chemical ligation is widely used for the convergent synthesis of proteins. The peptide thioesters required for this process can be challenging to…”
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Rapid Synthesis of Acyl Transfer Auxiliaries for Cysteine-Free Native Glycopeptide Ligation by Macmillan, Derek, Anderson, David W

“…Rapid, facile routes to the TFA-cleavable 4,5,6-trimethoxy-2-mercaptobenzyl and 1-(2,4-dimethoxyphenyl)-2-mercaptoethyl classes of auxiliaries for…”
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Modular Assembly of Glycoproteins: Towards the Synthesis of GlyCAM-1 by Using Expressed Protein Ligation by Macmillan, Derek, Bertozzi, Carolyn R.

“…Put the two together: Physiologically relevant glycoproteins containing saccharides at predetermined sites, such as GlyCAM‐1, can be generated from small…”
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The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator by Jungmichel, Stephanie, Clapperton, Julie A, Lloyd, Janette, Hari, Flurina J, Spycher, Christoph, Pavic, Lucijana, Li, Jiejin, Haire, Lesley F, Bonalli, Mario, Larsen, Dorthe H, Lukas, Claudia, Lukas, Jiri, MacMillan, Derek, Nielsen, Michael L, Stucki, Manuel, Smerdon, Stephen J

“…Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged…”
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Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement by Macmillan, Derek, De Cecco, Martin, Reynolds, Natalie L., Santos, Luiz F. A., Barran, Perdita E., Dorin, Julia R.

“…Latent thioesters: Reverse native chemical ligation followed by intramolecular trans‐thioesterification and acyl transfer can rearrange linear peptides into…”
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Evolving Strategies for Protein Synthesis Converge on Native Chemical Ligation by Macmillan, Derek

“…Build a bridge: Although used widely, certain limitations of popular protein assembly strategies such as native chemical ligation (NCL) have persisted. This…”
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Peptide Fragments of a β-Defensin Derivative with Potent Bactericidal Activity by REYNOLDS, Natalie L, DE CECCO, Martin, MACMILLAN, Derek, BARRAN, Perdita, DORIN, Julia R, TAYLOR, Karen, STANTON, Chloe, KILANOWSKI, Fiona, KALAPOTHAKIS, Jason, SEO, Emily, UHRIN, Dusan, CAMPOPIANO, Dominic, GOVAN, John

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Recent developments in the synthesis and discovery of oligosaccharides and glycoconjugates for the treatment of disease by Macmillan, Derek, Daines, Alison M

“…The development of the first automated oligosaccharide synthesizer, along with new methods for screening carbohydrate ligand arrays is likely to lead to a…”
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Elucidating the Function of Complex-Type Oligosaccharides by Use of Chemical Synthesis of Homogeneous Glycoproteins by Kajihara, Yasuhiro, Izumi, Masayuki, Hirano, Kiriko, Murase, Takefumi, Macmillan, Derek, Okamoto, Ryo

“…Protein glycosylation is a major post‐translational modification. To elucidate the effect of this modification on protein function, homogeneous glycoproteins…”
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Semisynthesis of Erythropoietin Analog Having Three Oligosaccharides by Hirano, Kiriko, Izumi, Masayuki, Macmillan, Derek, Tezuka, Katsunari, Tsuji, Takashi, Kajihara, Yasuhiro

“…An erythropoietin (EPO) analog having three complex-type biantennary sialyloligosaccharides was prepared. The full-length EPO glycopeptide was prepared through…”
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P20 Engineered peptide for KLK5 inhibition – therapeutic intervention for atopic dermatitis by Mah, Jeffrey, Macmillan, Derek, Di, Wei-Li

“…Abstract Epidermal proteases, such as human tissue kallikrein-related peptidase, regulate skin barrier function through keratinocyte desquamation,…”
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Peptide and protein thioester synthesis via N-->S acyl transfer by Kang, Jaskiranjit, Macmillan, Derek

“…Peptide and protein thioesters are playing an increasingly prominent role in the chemical toolbox for protein assembly and modification through Native Chemical…”
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Chk2 Oligomerization Studied by Phosphopeptide Ligation by Li, Jiejin, Taylor, Ian A., Lloyd, Janette, Clapperton, Julie A., Howell, Steven, MacMillan, Derek, Smerdon, Stephen J.

“…Chk2/CHEK2/hCds1 is a modular serine-threonine kinase involved in transducing DNA damage signals. Phosphorylation by ataxia telangiectasia-mutated kinase (ATM)…”
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Microwave-assisted synthesis of cyclopentadienone iron tricarbonyl complexes: molecular structures of [{η4-C4R2C(O)C4H8}Fe(CO)3] (R = Ph, 2,4-F2C6H3, 4-MeOC6H4) and attempts to prepare Fe(II) hydroxycyclopentadienyl–hydride complexes by Richard, Christian J., Macmillan, Derek, Hogarth, Graeme

“…Microwave irradiation of 1,6-diynes, RC≡C(CH 2 ) 4 C≡CR, with Fe(CO) 5 in dimethylether leads to the facile and clean formation of cyclopentadienone complexes…”
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Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods by Hirano, Kiriko, Macmillan, Derek, Tezuka, Katsunari, Tsuji, Takashi, Kajihara, Yasuhiro

“…Highly expressive: Cell proliferation was observed with concentrations of an erythropoietin (EPO) analogue above 50 pg mL−1. The EPO analogue has two human…”
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3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters by Kang, Jaskiranjit, Richardson, Jonathan P, Macmillan, Derek

“…Peptides and proteins fragment sequence-specifically in the presence of 3-mercaptopropionic acid to afford thioesters which can be used in native chemical…”
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Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity by Marchesan, Silvia, Macmillan, Derek

“…GDP-2-, 3-, 4- or 6-azidomannoses can be successfully prepared from the corresponding azidomannose-1-phosphates and GTP using the enzyme…”
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