Search Results - "MacManus, J. P."

Apoptosis after experimental stroke: fact or fashion? by MacManus, J P, Buchan, A M

“…This review examines the appearance of hallmarks of apoptosis following experimental stroke. The reviewed literature leaves no doubt that ischemic cell death…”
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Gene expression induced by cerebral ischemia: an apoptotic perspective by MacManus, J P, Linnik, M D

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Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1 by MacManus, J P, Koch, C J, Jian, M, Walker, T, Zurakowski, B

“…E2F1+/+ mice subjected to 2 h middle cerebral artery occlusion developed an infarct of 77.0 ± 3.2 mm (mean ± s.e.m., n = 15) in the ischemic hemisphere after…”
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Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain by MacManus, J P, Buchan, A M, Hill, I E, Rasquinha, I, Preston, E

“…Laddered DNA indicative of apoptosis was observed in the CA1 layer of hippocampus and in dorsolateral striatum following a global cerebral ischemic insult…”
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The Transcription Factor E2F1 Modulates Apoptosis of Neurons by Hou, Sheng T., Callaghan, Debbie, Fournier, Marie‐Christine, Hill, Irene, Kang, Liping, Massie, Bernard, Morley, Paul, Murray, Christine, Rasquinha, Ingrid, Slack, Ruth, MacManus, John P.

“…: The transcription factor E2F1 is known to mediate apoptosis in isolated quiescent and postmitotic cardiac myocytes, and its absence decreases the size of…”
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Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats by MacManus, J P, Hill, I E, Preston, E, Rasquinha, I, Walker, T, Buchan, A M

“…The time course of appearance of cells with DNA damage was studied in rats following transient severe forebrain ischemia. This DNA damage could be detected by…”
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DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat by Hill, Irene E., MacManus, John P., Rasquinha, Ingrid, Tuor, Ursula I.

“…DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved…”
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Cerebral Ischemia Produces Laddered DNA Fragments Distinct From Cardiac Ischemia and Archetypal Apoptosis by MacManus, John P., Fliss, Henry, Preston, Edward, Rasquinha, Ingrid, Tuor, Ursula

“…The electrophoretic pattern of laddered DNA fragments which has been observed after cerebral ischemia is considered to indicate that neurons are dying by…”
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Detection of higher-order 50- and 10-kbp DNA fragments before apoptotic internucleosomal cleavage after transient cerebral ischemia by MacManus, J P, Rasquinha, I, Tuor, U, Preston, E

“…DNA fragments of 50 and 10 kbp were found in ischemic brain in adult rats following two-vessel occlusion or in neonates following hypoxia-ischemia. These…”
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Activation of DNA‐Dependent Protein Kinase May Play a Role in Apoptosis of Human Neuroblastoma Cells by Chakravarthy, Balu R, Walker, Teena, Rasquinha, Ingrid, Hill, Irene E, MacManus, John P

“…: Treating SH‐SY5Y human neuroblastoma cells with 1 μM staurosporine resulted in a three‐ to fourfold higher DNA‐dependent protein kinase (DNA‐PK) activity…”
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Apoptosis is restricted to the thalamus in thiamine-deficient rats by MATSUSHIMA, K, MACMANUS, J. P, HAKIM, A. M

“…Thiamine deficiency (TD) produces lesions in the thalamus, mamillary and medial geniculate nuclei, and inferior colliculus. To clarify the pathogenesis of…”
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Comparison of terbium (III) luminescence enhancement in mutants of EF hand calcium binding proteins by HOGUE, C. W. V, MACMANUS, J. P, BANVILLE, D, SZABO, A. G

“…The luminescent isomorphous Ca2+ analogue, Tb3+, can be bound in the 12-amino acid metal binding sites of proteins of the EF hand family, and its luminescence…”
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Despite the Internucleosomal Cleavage of DNA, Reactive Oxygen Species Do Not Produce Other Markers of Apoptosis in Cultured Neurons by Hill, Irene E., Murray, Christine, Richard, Julie, Rasquinha, Ingrid, MacManus, John P.

“…The cell death induced by hydroxyl radicals generated by Cu-phenanthroline and peroxynitrite generated by 3-morpholinosydnonimine hydrochloride (SIN-1) in rat…”
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Calcium- and magnesium-binding properties of oncomodulin. Direct binding studies and microcalorimetry by COX, J. A, MILOS, M, MACMANUS, J. P

“…Ca2+ binding to the wild type recombinant oncomodulin was studied by equilibrium flow dialysis in the absence and presence of 1, 2, and 10 mM Mg2+. Direct…”
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Increased Mdm2 expression in rat brain after transient middle cerebral artery occlusion by Tu, Y, Hou, S T, Huang, Z, Robertson, G S, MacManus, J P

“…The negative regulator of p53 transactivation, Mdm2, increased in the ischemic territory after 90 minutes of transient middle cerebral artery occlusion in…”
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A new intrinsic fluorescent probe for proteins Biosynthetic incorporation of 5-hydroxytryptophan into oncomodulin by Hogue, Christopher W.V., Rasquinha, Ingrid, Szabo, Arthur G., MacManus, John P.

“…The tryptophan analog, 5-hydroxytryptophan (5HW), has a significant absorbance between 310–320 nm, which allows it to act as an exclusive fluorescence probe in…”
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Differential calmodulin gene expression in fetal, adult, and neoplastic tissues of rodents by MacManus, J P, Gillen, M F, Korczak, B, Nojima, H

“…Differential expression during rat development of three genes for calmodulin (CaM I-III) was examined in amnion, decidua, embryo, liver, placenta, parietal and…”
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A complete complementary DNA for the oncodevelopmental calcium-binding protein, oncomodulin by Gillen, M.F., Banville, D., Rutledge, R.G., Narang, S., Seligy, V.L., Whitfield, J.F., MacManus, J.P.

“…RNA from a rat liver tumor (Morris hepatoma 5123tc) was used to construct cDNAs together comprising the complete coding sequence of rat oncomodulin mRNA…”
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Immunocytochemical detection of the onco-developmental protein oncomodulin in pre-neoplastic and neoplastic hepatocellular lesions during hepatocarcinogenesis in rats by Bernaert, D, Brewer, L M, MacManus, J P, Galand, P

“…Oncomodulin is a calcium-binding protein, detectable in extra-embryonic human and rat placental cells and in a wide variety of tumors, but not in any normal…”
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Terbium luminescence in synthetic peptide loops from calcium-binding proteins with different energy donors by MacManus, J P, Hogue, C W, Marsden, B J, Sikorska, M, Szabo, A G

“…Fourteen 14-mer peptides corresponding to a consensus sequence of metal-binding loops from proteins of the calmodulin family were synthesized. The effect of…”
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