Search Results - "MacLeod, R A"

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders by QUENTMEIER, H, MACLEOD, R. A. F, ZABORSKI, M, DREXLER, H. G

“…A mutation in the JH2 pseudokinase domain of the Janus kinase 2 gene (JAK2 V617F) has been described in chronic myeloproliferative disorders (MPD). We screened…”
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Personalised 3D Printed high tibial osteotomy achieves a high level of accuracy: 'IDEAL' preclinical stage evaluation of a novel patient specific system by MacLeod, A R, Mandalia, V I, Mathews, J A, Toms, A D, Gill, H S

“…High tibial osteotomy (HTO) is an effective surgical treatment for isolated medial compartment knee osteoarthritis; however, widespread adoption is limited due…”
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Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750—an antisense oligonucleotide against eIF4E—in combination with irinotecan in solid tumors and irinotecan‐refractory colorectal cancer by Duffy, A.G., Makarova‐Rusher, O.V., Ulahannan, S.V., Rahma, O.E., Fioravanti, S., Walker, M., Abdullah, S., Raffeld, M., Anderson, V., Abi‐Jaoudeh, N., Levy, E., Wood, B.J., Lee, S., Tomita, Y., Trepel, J.B., Steinberg, S.M., Revenko, A.S., MacLeod, A.R., Peer, C.J., Figg, W.D., Greten, T.F.

“…The eukaryotic translation initiation factor 4E (eIF4E) is a potent oncogene that is found to be dysregulated in 30% of human cancer, including colorectal…”
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Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma by Meads, M B, Fang, B, Mathews, L, Gemmer, J, Nong, L, Rosado-Lopez, I, Nguyen, T, Ring, J E, Matsui, W, MacLeod, A R, Pachter, J A, Hazlehurst, L A, Koomen, J M, Shain, K H

“…Multiple myeloma (MM) remains an incurable malignancy due, in part, to the influence of the bone marrow microenvironment on survival and drug response…”
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A Biomechanical Comparison of Plate Configuration in Distal Humerus Fractures by Arnander, Magnus W T, Reeves, Alexander, MacLeod, Iain A R, Pinto, Thomas M, Khaleel, Arshad

“…OBJECTIVES:Our aim was to test the hypothesis that two plates placed parallel to each other are stronger and stiffer than plates placed perpendicular to each…”
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High level EGFR amplification in a newly established glioblastoma cell line 170-MG-BA by MacLeod, R A F, Schneider, B, Sivakova, I, Nagel, S, Dirks, W G, Mraz, P, Kubikova, E, Perzelova, A

“…Glioblastoma multiforme is a highly invasive and incurable primary brain tumor. The most frequent genetic alteration therein is amplification of the epidermal…”
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MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines by Nagel, S, Meyer, C, Quentmeier, H, Kaufmann, M, Drexler, H G, MacLeod, R A F

“…In T-cell acute lymphoblastic leukemia (T-ALL) the cardiac homeobox gene NKX2-5 (at 5q35) is variously deregulated by regulatory elements coordinating with…”
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U-2932: two clones in one cell line, a tool for the study of clonal evolution by Quentmeier, H, Amini, R M, Berglund, M, Dirks, W G, Ehrentraut, S, Geffers, R, MacLeod, R A F, Nagel, S, Romani, J, Scherr, M, Zaborski, M, Drexler, H G

“…Genetic heterogeneity is common in tumors, explicable by the development of subclones with distinct genetic and epigenetic alterations. We describe an in vitro…”
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Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma by Nagel, S, Leich, E, Quentmeier, H, Meyer, C, Kaufmann, M, Drexler, H G, Zettl, A, Rosenwald, A, MacLeod, R A F

“…Recurrent chromosomal aberrations in hematopoietic tumors target genes involved in pathogenesis. Their identification and functional characterization are…”
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SOCS2: inhibitor of JAK2V617F-mediated signal transduction by Quentmeier, H, Geffers, R, Jost, E, MacLeod, R A F, Nagel, S, Röhrs, S, Romani, J, Scherr, M, Zaborski, M, Drexler, H G

“…Janus kinase 2 ( JAK2 )V617F-activating mutations ( JAK2 mu) occur in myeloproliferative disorders (MPDs) and myelodysplastic syndromes (MDSs). Cell lines…”
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Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with MBNL1 and STAG2 by Chen, S, Nagel, S, Schneider, B, Kaufmann, M, Meyer, C, Zaborski, M, Kees, U R, Drexler, H G, MacLeod, R A F

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t(3;7)(q27;q32) fuses BCL6 to a non-coding region at FRA7H near miR-29 by Schneider, B, Nagel, S, Kaufmann, M, Winkelmann, S, Bode, J, Drexler, H G, MacLeod, R A F

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A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly by Stewart, D. J., Donehower, R. C., Eisenhauer, E. A., Wainman, N., Shah, A. K., Bonfils, C., MacLeod, A. R., Besterman, J. M., Reid, G. K.

“…Background: Hypermethylation and inactivation of tumor suppressor genes by the enzyme DNA methyltransferase may lead to neoplastic transformation. MG98, a…”
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Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing by Kreck, B, Richter, J, Ammerpohl, O, Barann, M, Esser, D, Petersen, B S, Vater, I, Murga Penas, E M, Bormann Chung, C A, Seisenberger, S, Lee Boyd, V, Smallwood, S, Drexler, H G, MacLeod, R A F, Hummel, M, Krueger, F, Häsler, R, Schreiber, S, Rosenstiel, P, Franke, A, Siebert, R

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Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes by SANDBERG, Y, VERHAAF, B, VAN GASTEL-MOL, E. J, WOLVERS-TETTERO, I. L. M, DE VOS, J, MACLEOD, R. A. F, NOORDZIJ, J. G, DIK, W. A, VAN DONGEN, J. J. M, LANGERAK, A. W

“…The BIOMED-2 multiplex polymerase chain reaction (PCR) tubes for analysis of immunoglobulin and T-cell receptor (TCR) gene rearrangements have recently been…”
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Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations by DREXLER, H. G, QUENTMEIER, H, MACLEOD, R. A. F

“…Human tumor cell lines are powerful tools for investigating basic and applied aspects of cell biology. Leukemia-lymphoma cell lines have been instrumental in…”
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Regulation of DNA Methylation by the Ras Signaling Pathway by MacLeod, A. Robert, Rouleau, Julie, Szyf, Moshe

“…We demonstrate that DNA methylation in an adrenocortical tumor cell line, Y1, is controlled by the Ras signaling pathway. Forced expression of a cDNA encoding…”
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A second NOTCH1 chromosome rearrangement: t(9;14)(q34.3;q11.2) in T-cell neoplasia by Suzuki, S, Nagel, S, Schneider, B, Chen, S, Kaufmann, M, Uozumi, K, Arima, N, Drexler, H G, MacLeod, R A F

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Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin by QUENTMEIER, H, MARTELLI, M. P, MARTELLI, M. F, MECUCCI, C, DREXLER, H. G, FALINI, B, DIRKS, W. G, BOLLI, N, LISO, A, MACLEOD, R. A. F, NICOLETTI, I, MANNUCCI, R, PUCCIARINI, A, BIGERNA, B

“…We recently identified a new acute myeloid leukemia (AML) subtype characterized by mutations at exon-12 of the nucleophosmin (NPM) gene and aberrant…”
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False leukemia-lymphoma cell lines: an update on over 500 cell lines by DREXLER, H. G, DIRKS, W. G, MATSUO, Y, MACLEOD, R. A. F

“…Human leukemia-lymphoma (LL) cell lines represent an extremely important resource for research in a variety of fields and disciplines. As the cell lines are…”
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