Search Results - "MacLeod, Michael C."

ATF3-Induced Mammary Tumors Exhibit Molecular Features of Human Basal-Like Breast Cancer by Yan, Leqin, Gaddis, Sally, Coletta, Luis Della, Repass, John, Powell, Katherine Leslie, Simper, Melissa S, Chen, Yueping, Byrom, Michelle, Zhong, Yi, Lin, Kevin, Liu, Bin, Lu, Yue, Shen, Jianjun, MacLeod, Michael C

“…Basal-like breast cancer (BLBC) is an aggressive and deadly subtype of human breast cancer that is highly metastatic, displays stem-cell like features, and has…”
Get full text

Activation of the canonical Wnt/β-catenin pathway in ATF3-induced mammary tumors by Yan, Leqin, Della Coletta, Luis, Powell, K Leslie, Shen, Jianjun, Thames, Howard, Aldaz, C Marcelo, MacLeod, Michael C

“…Female transgenic mice that constitutively overexpress the transcription factor ATF3 in the basal epithelium of the mammary gland develop mammary carcinomas…”
Get full text

Late Cornified Envelope Family in Differentiating Epithelia—Response to Calcium and Ultraviolet Irradiation by Jackson, Benjamin, Tilli, Claudia M.L.J., Hardman, Matthew J., Avilion, Ariel A., MacLeod, Michael C., Ashcroft, Gillian S., Byrne, Carolyn

“…The late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome one (mouse chromosome three) contains multiple…”
Get full text

The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis by Wang, Aijin, Arantes, Stacey, Yan, Leqin, Kiguchi, Kaoru, McArthur, Mark J, Sahin, Aysegul, Thames, Howard D, Aldaz, C Marcelo, Macleod, Michael C

“…Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5)…”
Get full text

High-affinity triplex-forming oligonucleotide target sequences in mammalian genomes by Wu, Qi, Gaddis, Sara S., MacLeod, Michael C., Walborg, Earl F., Thames, Howard D., DiGiovanni, John, Vasquez, Karen M.

“…Site‐specific recognition of duplex DNA by triplex‐forming oligonucleotides (TFOs) provides a promising approach to manipulate mammalian genomes. A…”
Get full text

Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells by Wang, Aijin, Arantes, Stacey, Conti, Claudio, McArthur, Mark, Aldaz, C. Marcelo, MacLeod, Michael C.

“…ATF3 is a highly conserved eukaryotic transcription factor that is ubiquitously upregulated transcriptionally during cellular responses to a variety of…”
Get full text

Detoxication of Sulfur Half-Mustards by Nucleophilic Scavengers: Robust Activity of Thiopurines by Liu, Jinyun, Powell, K. Leslie, Thames, Howard D, MacLeod, Michael C

“…Sulfur mustard (bis-(2-chloroethyl)sulfide) has been used in chemical warfare since World War I and is well known as an acutely toxic vesicant. It has been…”
Get full text

Protection against 2-chloroethyl ethyl sulfide (CEES) — induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway by Abel, Erika L., Bubel, Jennifer D., Simper, Melissa S., Powell, Leslie, McClellan, S. Alex, Andreeff, Michael, MacLeod, Michael C., DiGiovanni, John

“…Sulfur mustard (SM or mustard gas) was first used as a chemical warfare agent almost 100years ago. Due to its toxic effects on the eyes, lungs, and skin, and…”
Get full text

2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog by Boulware, Stephen, Fields, Tammy, McIvor, Elizabeth, Powell, K. Leslie, Abel, Erika L., Vasquez, Karen M., MacLeod, Michael C.

“…Sulfur mustard [bis(2-chloroethyl)sulfide, SM] is a well-known DNA-damaging agent that has been used in chemical warfare since World War I, and is a weapon…”
Get full text

Effects of estrogen on global gene expression : Identification of novel targets of estrogen action by CHARPENTIER, April H, BEDNAREK, Andrzej K, DANIEL, Rachael L, HAWKINS, Kathleen A, LAFLIN, Kendra J, GADDIS, Sara, MACLEOD, Michael C, ALDAZ, C. Marcelo

“…The important role played by the sex hormone estrogen in disease and physiological processes has been well documented. However, the mechanisms by which this…”
Get full text

2,6-Dithiopurine Blocks Toxicity and Mutagenesis in Human Skin Cells Exposed to Sulfur Mustard Analogues, 2-Chloroethyl Ethyl Sulfide and 2-Chloroethyl Methyl Sulfide by Powell, K. Leslie, Boulware, Stephen, Thames, Howard, Vasquez, Karen M, MacLeod, Michael C

“…Sulfur mustard (bis-(2-chloroethyl)sulfide) is a well-known chemical warfare agent that induces debilitating cutaneous toxicity in exposed individuals. It is…”
Get full text

Targeted Generation of DNA Strand Breaks Using Pyrene-Conjugated Triplex-Forming Oligonucleotides by Benfield, Aaron P, Macleod, Michael C, Liu, Yaobin, Wu, Qi, Wensel, Theodore G, Vasquez, Karen M

“…Gene targeting by triplex-forming oligonucleotides (TFOs) has proven useful for gene modulation in vivo. Photoreactive molecules have been conjugated to TFOs…”
Get full text

Regulation of BRCA1 Expression by the Rb-E2F Pathway by Wang, Aijin, Schneider-Broussard, Robin, Kumar, Addanki P., MacLeod, Michael C., Johnson, David G.

“…Inheritance of a mutant allele of the breast cancer susceptibility gene BRCA1 confers increased risk of developing breast and ovarian cancers. Likewise,…”
Get full text

Response of human mammary epithelial cells to DNA damage induced by BPDE: involvement of novel regulatory pathways by Wang, Aijin, Gu, Jing, Judson-Kremer, Kimberly, Powell, K.Leslie, Mistry, Harsha, Simhambhatla, Padmaja, Aldaz, C. Marcelo, Gaddis, Sally, MacLeod, Michael C.

“…The responses of a line of normal human mammary epithelial cells, HME87, to treatment with the ultimate carcinogen benzo[a]pyrene diol epoxide (BPDE) were…”
Get full text

Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR by Thavathiru, Elangovan, Ludes-Meyers, John H., MacLeod, Michael C., Aldaz, C. Marcelo

“…Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these…”
Get full text

The Evolution of Legislative Jurisdictions by Baumgartner, Frank R., Jones, Bryan D., Macleod, Michael C.

“…We consider the clarity of the jurisdictions of the committees of the U.S. Congress over the entire post-war period. We offer a theory to explain changes in…”
Get full text

Rapid analysis of gene expression (RAGE) facilitates universal expression profiling by Wang, Aijin, Pierce, Angela, Kimberly, Judson-Kremer, Gaddis, Sara, Aldaz, C. Marcelo, Johnson, David G., MacLeod, Michael C.

“…Current techniques for analysis of gene expression either monitor one gene at a time, for example northern hybridization or RT-PCR methods, or are designed for…”
Get full text

Quantitative high-throughput measurement of gene expression with sub-zeptomole sensitivity by capillary electrophoresis by Spyres, Lea, Gaddis, Sally, Bedford, Ella, Arantes, Stacey, Liburd, Nikki, Powell, K. Leslie, Thames, Howard, Mitchell, David, Walborg, Earl, Rouabhia, Mahmoud, Aldaz, C. Marcelo, MacLeod, Michael C.

“…Microarray technologies have provided the ability to monitor the expression of whole genomes rapidly. However, concerns persist with regard to quantitation and…”
Get full text

Molecular Cloning and Characterization of a Novel Mouse Epidermal Differentiation Gene and Its Promoter by Wang, Aijin, Johnson, David G., MacLeod, Michael C.

“…The transcription factor E2F1 is an important regulator of cell proliferation, apoptosis, and differentiation. A novel mouse gene (Eig3) was originally…”
Get full text

Kinetics of the Reaction of a Potential Chemopreventive Agent, 2,6-Dithiopurine, and Its Major Metabolite, 2,6-Dithiouric Acid, with Multiple Classes of Electrophilic Toxicants by Qing, Wei-Guo, Powell, K. Leslie, MacLeod, Michael C

“…Purinethiols are a class of potential cancer chemopreventive agents that exhibit nucleophilic scavenging activity against the carcinogenic electrophile…”
Get full text