Search Results - "MacLeod, Megan K.L."

Memory CD4 T cells: generation, reactivation and re-assignment by MacLeod, Megan K.L, Kappler, John W, Marrack, Philippa

“…Immunological memory is one of the features that define the adaptive immune response: by generating specific memory cells after infection or vaccination, the…”
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Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells by MacLeod, Megan K.L, McKee, Amy S, David, Alexandria, Wang, Jieru, Mason, Robert, Kappler, John W, Marrack, Philippa

“…Vaccines can greatly reduce the spread of and deaths from many infectious diseases. However, many infections have no successful vaccines. Better understanding…”
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CD4 memory T cells: What are they and what can they do? by MacLeod, Megan K.L, Clambey, Eric T, Kappler, John W, Marrack, Philippa

“…Abstract Immunological memory provides the basis for successful vaccines. It is important to understand the properties of memory cells. There is much known…”
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T Cell Response in the Lung Following Influenza Virus Infection by Benson, Robert A, Lawton, Jennifer C, MacLeod, Megan K L

“…Methods that enable the identification of virus-specific CD4 and CD8 T cells are key to our understanding of how the adaptive immune response controls viral…”
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Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells by Oliver, Paula M, Yang, Baoli, Gay, Denise L, MacLeod, Megan K L, Cao, Xiao, Hala, Tamara, Sweezer, Eileen M, Kappler, John, Marrack, Philippa

“…The E3 ubiquitin ligases Itch and Nedd4 target similar proteins in vitro . Oliver and colleagues find that unlike hyper-responsive Itch-mutant T cells,…”
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Terminating the immune response by Marrack, Philippa, Scott-Browne, James, MacLeod, Megan K.L

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CD4 memory T cells divide poorly in response to antigen because of their cytokine profile by MacLeod, Megan K.L, McKee, Amy, Crawford, Frances, White, Janice, Kappler, John, Marrack, Philippa

“…Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated…”
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The roles of resident, central and effector memory CD4 T‐cells in protective immunity following infection or vaccination by Gray, Joshua I., Westerhof, Lotus M., MacLeod, Megan K. L.

“…Summary Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T‐cells play a central role in…”
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Stromal–immune cell crosstalk fundamentally alters the lung microenvironment following tissue insult by Worrell, Julie C., MacLeod, Megan K. L.

“…Summary Communication between stromal and immune cells is essential to maintain tissue homeostasis, mount an effective immune response and promote tissue…”
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Chemokine Receptor Redundancy and Specificity Are Context Dependent by Dyer, Douglas P., Medina-Ruiz, Laura, Bartolini, Robin, Schuette, Fabian, Hughes, Catherine E., Pallas, Kenneth, Vidler, Francesca, Macleod, Megan K.L., Kelly, Christopher J., Lee, Kit Ming, Hansell, Christopher A.H., Graham, Gerard J.

“…Currently, we lack an understanding of the individual and combinatorial roles for chemokine receptors in the inflammatory process. We report studies on mice…”
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Antigen presenting cells: Professionals, amateurs, and spectators in the 'long game' of lung immunity by Hargrave, Kerrie E., MacLeod, Megan K.L., Worrell, Julie C.

“…The lung is frequently and repeatedly exposed to invading pathogens and thus requires constant immunosurveillance. Professional antigen presenting cells…”
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BTN3A3 evasion promotes the zoonotic potential of influenza A viruses by Pinto, Rute Maria, Bakshi, Siddharth, Lytras, Spyros, Zakaria, Mohammad Khalid, Swingler, Simon, Worrell, Julie C., Herder, Vanessa, Hargrave, Kerrie E., Varjak, Margus, Cameron-Ruiz, Natalia, Collados Rodriguez, Mila, Varela, Mariana, Wickenhagen, Arthur, Loney, Colin, Pei, Yanlong, Hughes, Joseph, Valette, Elise, Turnbull, Matthew L., Furnon, Wilhelm, Gu, Quan, Orr, Lauren, Taggart, Aislynn, Diebold, Ola, Davis, Chris, Boutell, Chris, Grey, Finn, Hutchinson, Edward, Digard, Paul, Monne, Isabella, Wootton, Sarah K., MacLeod, Megan K. L., Wilson, Sam J., Palmarini, Massimo

“…Spillover events of avian influenza A viruses (IAVs) to humans could represent the first step in a future pandemic 1 . Several factors that limit the…”
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Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity by McKee, Amy S, Munks, Michael W, MacLeod, Megan K. L, Fleenor, Courtney J, Van Rooijen, Nico, Kappler, John W, Marrack, Philippa

“…To understand more about how the body recognizes alum we characterized the early innate and adaptive responses in mice injected with the adjuvant. Within hours…”
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Multifunctional cytokine production reveals functional superiority of memory CD4 T cells by Westerhof, Lotus M, McGuire, Kris, MacLellan, Lindsay, Flynn, Ashley, Gray, Joshua I, Thomas, Matthew, Goodyear, Carl S, MacLeod, Megan KL

“…T cell protective immunity is associated with multifunctional memory cells that produce several different cytokines. Currently, our understanding of when and…”
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Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules by Westerhof, Lotus M, Noonan, Jonathan, Hargrave, Kerrie E, Chimbayo, Elizabeth T, Cheng, Zhiling, Purnell, Thomas, Jackson, Mark R, Borcherding, Nicholas, MacLeod, Megan K L

“…Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the persistence of cytokine…”
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Low-Dose Lung Radiation Therapy for COVID-19 Lung Disease: A Preclinical Efficacy Study in a Bleomycin Model of Pneumonitis by Jackson, Mark R., Stevenson, Katrina, Chahal, Sandeep K., Curley, Emer, Finney, George E., Gutierrez-Quintana, Rodrigo, Onwubiko, Evarest, Rupp, Angie, Strathdee, Karen, Williams, Karin, MacLeod, Megan K.L., McSharry, Charles, Chalmers, Anthony J.

“…Low-dose whole lung radiation therapy (LDLR) has been proposed as a treatment for patients with acute respiratory distress syndrome associated with SARS-CoV-2…”
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Memory CD4 T cells that express CXCR5 provide accelerated help to B cells by MacLeod, Megan K L, David, Alexandria, McKee, Amy S, Crawford, Frances, Kappler, John W, Marrack, Philippa

“…CD4 T cell help for B cells is critical for effective Ab responses. Although many of the molecules involved in helper functions of naive CD4 T cells have been…”
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The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis by Hansell, Christopher A H, Fraser, Alasdair R, Hayes, Alan J, Pingen, Marieke, Burt, Claire L, Lee, Kit Ming, Medina-Ruiz, Laura, Brownlie, Demi, Macleod, Megan K L, Burgoyne, Paul, Wilson, Gillian J, Nibbs, Robert J B, Graham, Gerard J

“…Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine…”
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Lung influenza virus-specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells by Hargrave, Kerrie E., Worrell, Julie C., Pirillo, Chiara, Brennan, Euan, Masdefiol Garriga, Andreu, Gray, Joshua I., Purnell, Thomas, Roberts, Edward W., MacLeod, Megan K.L.

“…[Display omitted] •Lung influenza A virus (IAV)-specific cluster of differentiation (CD)4 T cells are located near major histocompatibility complex (MHC)II+…”
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Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection by Clay, Slater L., Bravo-Blas, Alberto, Wall, Daniel M., MacLeod, Megan K. L., Milling, Simon W. F.

“…FoxP3 + regulatory T cells (Tregs) control inflammation and maintain mucosal homeostasis, but their functions during infection are poorly understood. Th1, Th2,…”
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