Search Results - "MacLeod, Kathryn J"

4-1BB Ligand as an Effective Multifunctional Immunomodulator and Antigen Delivery Vehicle for the Development of Therapeutic Cancer Vaccines by SHARMA, Rajesh K, SCHABOWSKY, Rich-Henry, SHIRWAN, Haval, SRIVASTAVA, Abhishek K, ELPEK, Kutlu G, MADIREDD, Shravan, HONG ZHAO, ZHENPING ZHONG, MILLER, Robert W, MACLEOD, Kathryn J, YOLCU, Esma S

“…Therapeutic subunit vaccines based on tumor-associated antigens (TAA) represent an attractive approach for the treatment of cancer. However, poor…”
Get full text

Constitutive Phosphorylation of Human Endothelin-converting Enzyme-1 Isoforms by MacLeod, Kathryn J, Husain, Rhonda D, Gage, Douglas A, Ahn, Kyunghye

“…To investigate the phosphorylation of human endothelin-converting enzyme-1 (hECE-1) and identify potential residues involved, both in vivo and in vitro…”
Get full text

SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model by Sharma, Rajesh K, Srivastava, Abhishek K, Yolcu, Esma S, MacLeod, Kathryn J, Schabowsky, Rich-Henry, Madireddi, Shravan, Shirwan, Haval

“…Abstract Cervical cancer is the leading cause of cancer-related deaths among women worldwide. Current prophylactic vaccines based on HPV (Human papillomavirus)…”
Get full text

A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity by Schabowsky, Rich-Henry, Elpek, Kutlu G, Madireddi, Shravan, Sharma, Rajesh K, Yolcu, Esma S, Bandura-Morgan, Laura, Miller, Robert, MacLeod, Kathryn J, Mittler, Robert S, Shirwan, Haval

“…Abstract Agonistic Abs to select costimulatory members of CD28 and TNFR family have shown efficacy in various preclinical cancer immunotherapeutic settings…”
Get full text

Cysteine Scanning Mutagenesis of the Noncatalytic Nucleotide Binding Site of the Yeast V-ATPase by Vasilyeva, E, Liu, Q, MacLeod, K J, Baleja, J D, Forgac, M

“…To investigate residues involved in the formation of the noncatalytic nucleotide binding sites of the vacuolar proton-translocating adenosine triphosphatase…”
Get full text

Mutational Analysis of the Nucleotide Binding Sites of the Yeast Vacuolar Proton-translocating ATPase by MacLeod, Kathryn J., Vasilyeva, Elena, Baleja, James D., Forgac, Michael

“…To further define the structure of the nucleotide binding sites on the vacuolar proton-translocating ATPase (V-ATPase), the role of aromatic residues at the…”
Get full text

Conserved Cysteine and Tryptophan Residues of the Endothelin-converting Enzyme-1 CXAW Motif Are Critical for Protein Maturation and Enzyme Activity by MacLeod, K J, Fuller, R S, Scholten, J D, Ahn, K

“…The neprilysin (NEP)/endothelin-converting enzyme (ECE) family of metalloproteases contains a highly conserved carboxyl-terminal tetrapeptide sequence, C XA W,…”
Get full text

Photoaffinity Labeling of Wild-type and Mutant Forms of the Yeast V-ATPase A Subunit by 2-Azido-[32P]ADP by MacLeod, Kathryn J., Vasilyeva, Elena, Merdek, Keith, Vogel, Pia D., Forgac, Michael

“…Molecular modeling studies have previously suggested the possible presence of four aromatic residues (Phe452, Tyr532, Tyr535, and Phe538) near the adenine…”
Get full text

A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity by SCHABOWSKY, Rich-Henry, ELPEK, Kutlu G, MADIREDDI, Shravan, SHARMA, Rajesh K, YOLCU, Esma S, BANDURA-MORGAN, Laura, MILLER, Robert, MACLEOD, Kathryn J, MITTLER, Robert S, SHIRWAN, Haval

Get full text