Search Results - "MacLeod, Jeanna M."

Isolation of a jadomycin incorporating l-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells by Forget, Stephanie M., Robertson, Andrew W., Hall, Steven R., MacLeod, Jeanna M., Overy, David P., Kerr, Russell G., Goralski, Kerry B., Jakeman, David L.

“…Herein, we report the characterization and antimicrobial activity of a previously unreported jadomycin ( 1 ) obtained from a culture of S. venezuelae ISP5230…”
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Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models by McKeown, Brendan T, Relja, Nicholas J, Hall, Steven R, Gebremeskel, Simon, MacLeod, Jeanna M, Veinotte, Chansey J, Bennett, Leah G, Ohlund, Leanne B, Sleno, Lekha, Jakeman, David L, Berman, Jason N, Johnston, Brent, Goralski, Kerry B

“…Despite numerous therapeutic options, multidrug resistance (MDR) remains an obstacle to successful breast cancer therapy. Jadomycin B, a natural product…”
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Post Polyketide Synthase Carbon–Carbon Bond Formation in Type-II PKS-Derived Natural Products from Streptomyces venezuelae by Robertson, Andrew W, MacLeod, Jeanna M, MacIntyre, Logan W, Forget, Stephanie. M, Hall, Steven R, Bennett, Leah G, Correa, Hebelin, Kerr, Russell G, Goralski, Kerry B, Jakeman, David L

“…Polyketide synthase (PKS) derived natural products are biosynthesized by head-to-tail addition of acetate and malonate extender units resulting in linear…”
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The expansive library of jadomycins by MacLeod, Jeanna M, Forget, Stephanie M, Jakeman, David L

“…The jadomycin family of natural products was discovered from Streptomyces venezuelae ISP5230 in the 1990s. Subsequent identification of the biosynthetic gene…”
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Isolation of a post-PKS C–C branching jadomycin from S. venezuelae ISP5230 in the presence of 8-aminooctanoic acid by MacLeod, Jeanna M, Forget, Stephanie M, Martinez-Farina, Camilo F, Jakeman, David L

“…The jadomycin family of natural products was first identified and characterized by Vining and co-workers at Dalhousie University in the 1990s. Herein, we…”
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