Search Results - "MacLeod, F."

Autophagy, cancer stem cells and drug resistance by Smith, Alexandra G, Macleod, Kay F

“…Autophagy is a cellular survival mechanism that is induced by cancer therapy, among other stresses, and frequently contributes to cancer cell survival during…”
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Autophagy: cellular and molecular mechanisms by Glick, Danielle, Barth, Sandra, Macleod, Kay F

“…Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress…”
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Functions of autophagy in the tumor microenvironment and cancer metastasis by Mowers, Erin E., Sharifi, Marina N., Macleod, Kay F.

“…Macro‐autophagy is an ancient and highly conserved self‐degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens,…”
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In Brief: Mitophagy: mechanisms and role in human disease by Springer, Maya Z, Macleod, Kay F

“…Mitophagy is a selective form of macro‐autophagy in which mitochondria are specifically targeted for autophagic degradation. Mitophagy plays an important role…”
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Autophagy: assays and artifacts by Barth, Sandra, Glick, Danielle, Macleod, Kay F

“…Autophagy is a fundamental and phylogenetically conserved self-degradation process that is characterized by the formation of double-layered vesicles…”
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Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3 by Sharifi, Marina N., Mowers, Erin E., Drake, Lauren E., Collier, Chris, Chen, Hong, Zamora, Marta, Mui, Stephanie, Macleod, Kay F.

“…Autophagy is a conserved catabolic process that plays a housekeeping role in eliminating protein aggregates and organelles and is activated during nutrient…”
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Mitophagy and Mitochondrial Dysfunction in Cancer by Macleod, Kay F

“…The process of mitophagy, in which mitochondria are selectively turned over at the autophagolysosome, plays a central role in both eliminating dysfunctional…”
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Mitochondrial dysfunction in cancer by Boland, Michelle L, Chourasia, Aparajita H, Macleod, Kay F

“…A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research…”
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ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3 by Poole, Logan P., Bock-Hughes, Althea, Berardi, Damian E., Macleod, Kay F.

“…UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1…”
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Expanding perspectives on the significance of mitophagy in cancer by Drake, Lauren E, Springer, Maya Z, Poole, Logan P, Kim, Casey J, Macleod, Kay F

“…Abstract Mitophagy is a selective mode of autophagy in which mitochondria are selectively targeted for degradation at the autophagolysosome. Mitophagy is…”
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Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis by Chourasia, Aparajita H, Tracy, Kristin, Frankenberger, Casey, Boland, Michelle L, Sharifi, Marina N, Drake, Lauren E, Sachleben, Joseph R, Asara, John M, Locasale, Jason W, Karczmar, Gregory S, Macleod, Kay F

“…BNip3 is a hypoxia‐inducible protein that targets mitochondria for autophagosomal degradation. We report a novel tumor suppressor role for BNip3 in a…”
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A Laboratory Model for a Meandering Zonal Jet by Stewart, K. D., Macleod, F.

“…The meandering jet streams of the Northern Hemisphere influence the weather for more than half of Earth's population, so it is imperative that we improve our…”
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The LL-100 panel: 100 cell lines for blood cancer studies by Quentmeier, Hilmar, Pommerenke, Claudia, Dirks, Wilhelm G., Eberth, Sonja, Koeppel, Max, MacLeod, Roderick A. F., Nagel, Stefan, Steube, Klaus, Uphoff, Cord C., Drexler, Hans G.

“…For many years, immortalized cell lines have been used as model systems for cancer research. Cell line panels were established for basic research and drug…”
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BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver by Glick, Danielle, Zhang, Wenshuo, Beaton, Michelle, Marsboom, Glenn, Gruber, Michaela, Simon, M. Celeste, Hart, John, Dorn, Gerald W., Brady, Matthew J., Macleod, Kay F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors by Malone, Clare F, Emerson, Chloe, Ingraham, Rachel, Barbosa, William, Guerra, Stephanie, Yoon, Haejin, Liu, Lin L, Michor, Franziska, Haigis, Marcia, Macleod, Kay F, Maertens, Ophélia, Cichowski, Karen

“…Although agents that inhibit specific oncogenic kinases have been successful in a subset of cancers, there are currently few treatment options for malignancies…”
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Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors by De Raedt, Thomas, Walton, Zandra, Yecies, Jessica L., Li, Danan, Chen, Yimei, Malone, Clare F., Maertens, Ophélia, Jeong, Seung Min, Bronson, Roderick T., Lebleu, Valerie, Kalluri, Raghu, Normant, Emmanuel, Haigis, Marcia C., Manning, Brendan D., Wong, Kwok-Kin, Macleod, Kay F., Cichowski, Karen

“…Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for two Ras-driven cancers:…”
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Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification by Yan, Lingzhi, Ping, Nana, Zhu, Mingqing, Sun, Aining, Xue, Yongquan, Ruan, Changgeng, Drexler, Hans G, Macleod, Roderick A F, Wu, Depei, Chen, Suning

“…Among 4,780 consecutive adult acute lymphoblastic/myeloblastic leukemia patients, we identified 117 (2.4%) patients with mixed-phenotype acute leukemia…”
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Establishment of the Myeloid TBX-Code Reveals Aberrant Expression of T-Box Gene TBX1 in Chronic Myeloid Leukemia by Nagel, Stefan, Haake, Josephine, Pommerenke, Claudia, Meyer, Corinna, MacLeod, Roderick A F

“…T-box genes encode transcription factors, which control developmental processes and promote cancer if deregulated. Recently, we described the lymphoid…”
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Establishment of the TALE-code reveals aberrantly activated homeobox gene PBX1 in Hodgkin lymphoma by Nagel, Stefan, Pommerenke, Claudia, Meyer, Corinna, MacLeod, Roderick A F, Drexler, Hans G

“…Homeobox genes encode transcription factors which regulate basic processes in development and cell differentiation and are grouped into classes and subclasses…”
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The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia by Nagel, Stefan, Pommerenke, Claudia, Meyer, Corinna, MacLeod, Roderick A F

“…Homeobox genes encode transcription factors that control basic developmental decisions. Knowledge of their hematopoietic activities casts light on normal and…”
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