Search Results - "MacLeod, Amanda S."

Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi by Coates, Margaret, Blanchard, Sarah, MacLeod, Amanda S

“…AMP, antimicrobial protein; DAMP, damage-associated molecular pattern; hBD2, human β-defensin-2; HSV, herpes simplex virus; IL, interleukin; IFN, interferon;…”
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Autoimmune Theories of Chronic Spontaneous Urticaria by Bracken, Sonali J, Abraham, Soman, MacLeod, Amanda S

“…Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition…”
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The Cutaneous Wound Innate Immunological Microenvironment by Kirchner, Stephen, Lei, Vivian, MacLeod, Amanda S

“…The skin represents the first line of defense and innate immune protection against pathogens. Skin normally provides a physical barrier to prevent infection by…”
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The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems by Coates, Margaret, Lee, Min Jin, Norton, Diana, MacLeod, Amanda S

“…The skin and intestine are active organs of the immune system that are constantly exposed to the outside environment. They support diverse microbiota, both…”
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Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch by Chen, Yong, Fang, Quan, Wang, Zilong, Zhang, Jennifer Y., MacLeod, Amanda S., Hall, Russell P., Liedtke, Wolfgang B.

“…TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to…”
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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles by Choi, Hae Woong, Suwanpradid, Jutamas, Kim, Il Hwan, Staats, Herman F, Haniffa, Muzlifah, MacLeod, Amanda S, Abraham, Soman N

“…Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing…”
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The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin by Coates, Margaret, Mariottoni, Paula, Corcoran, David L, Kirshner, Hélène Fradin, Jaleel, Tarannum, Brown, David A, Brooks, Stephen R, Murray, John, Morasso, Maria I, MacLeod, Amanda S

“…Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease resulting in non-healing wounds affecting body areas of high hair follicle…”
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Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity by Brys, Adam K., Rodriguez-Homs, Larissa G., Suwanpradid, Jutamas, Atwater, Amber Reck, MacLeod, Amanda S.

“…The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However,…”
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Inverted U‐shaped relationship between vitamin D and ever‐reported eczema in US adults by Wei, Jia, Jaleel, Tarannum, MacLeod, Amanda S., Ji, John S.

“…Background Eczema is a skin condition which affects up to 10% to 20% of people worldwide. Previous literature finds that low vitamin D levels may be a risk…”
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Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion by Lei, Vivian, Petty, Amy J, Atwater, Amber R, Wolfe, Sarah A, MacLeod, Amanda S

“…The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between…”
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Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice by Reyes, Nancy J, Yu, Chen, Mathew, Rose, Kunnen, Carolina M, Kalnitsky, Joan, Redfern, Rachel L, Leonardi, Andrea, Perez, Victor L, MacLeod, Amanda S, Gupta, Preeya K, Saban, Daniel R

“…Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids needed to avert tear evaporation and to help maintain ocular surface…”
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Editorial: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses by Zhou, Xu-jie, MacLeod, Amanda S., Tsoi, Lam Cheung

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IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense by Yang, Bin, Suwanpradid, Jutamas, Sanchez-Lagunes, Roberto, Choi, Hae Woong, Hoang, Peter, Wang, Donghai, Abraham, Soman N., MacLeod, Amanda S.

“…Skin wound repair requires a coordinated program of epithelial cell proliferation and differentiation as well as resistance to invading microbes. However, the…”
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Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity by Suwanpradid, Jutamas, Shih, Michael, Pontius, Lauren, Yang, Bin, Birukova, Anastasiya, Guttman-Yassky, Emma, Corcoran, David L, Que, Loretta G, Tighe, Robert M, MacLeod, Amanda S

“…The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis…”
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Multifactorial Design of a Supramolecular Peptide Anti-IL-17 Vaccine Toward the Treatment of Psoriasis by Shores, Lucas S, Kelly, Sean H, Hainline, Kelly M, Suwanpradid, Jutamas, MacLeod, Amanda S, Collier, Joel H

“…Current treatments for chronic immune-mediated diseases such as psoriasis, rheumatoid arthritis, or Crohn's disease commonly rely on cytokine neutralization…”
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Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation by Smith, Jeffrey S, Nicholson, Lowell T, Suwanpradid, Jutamas, Glenn, Rachel A, Knape, Nicole M, Alagesan, Priya, Gundry, Jaimee N, Wehrman, Thomas S, Atwater, Amber Reck, Gunn, Michael D, MacLeod, Amanda S, Rajagopal, Sudarshan

“…The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, drugs targeting…”
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Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions by Jiang, Simon W., Whitley, Melodi Javid, Mariottoni, Paula, Jaleel, Tarannum, MacLeod, Amanda S.

“…Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly…”
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IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses by Suwanpradid, Jutamas, Lee, Min Jin, Hoang, Peter, Kwock, Jeffery, Floyd, Lauren P, Smith, Jeffrey S, Yin, Zhinan, Atwater, Amber R, Rajagopal, Sudarshan, Kedl, Ross M, Corcoran, David L, Zhang, Jennifer Y, MacLeod, Amanda S

“…Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters within barrier tissues provides a new concept for T cell activation…”
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Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa by Mariottoni, Paula, Jiang, Simon W, Prestwood, Courtney A, Jain, Vaibhav, Suwanpradid, Jutamas, Whitley, Melodi Javid, Coates, Margaret, Brown, David A, Erdmann, Detlev, Corcoran, David L, Gregory, Simon G, Jaleel, Tarannum, Zhang, Jennifer Y, Harris-Tryon, Tamia A, MacLeod, Amanda S

“…Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair…”
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An aging-susceptible circadian rhythm controls cutaneous antiviral immunity by Kirchner, Stephen J, Lei, Vivian, Kim, Paul T, Patel, Meera, Shannon, Jessica L, Corcoran, David, Hughes, Dalton, Waters, Diana K, Dzirasa, Kafui, Erdmann, Detlev, Coers, Jörn, MacLeod, Amanda S, Zhang, Jennifer Y

“…Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human…”
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