Search Results - "MacLeod, A"

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines by Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J

“…Abstract Antisense oligonucleotides (ASOs) modulate cellular target gene expression through direct binding to complementary RNA. Advances in ASO chemistry have…”
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The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells by GUTSCHNER, Tony, HÄMMERLE, Monika, ZÖRNIG, Martin, ROBERT MACLEOD, A, SPECTOR, David L, DIEDERICHS, Sven, EIBMANN, Moritz, HSU, Jeff, KIM, Youngsoo, HUNG, Gene, REVENKO, Alexey, ARUN, Gayatri, STENTRUP, Marion, GROSS, Matthias

“…The long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), also known as MALAT-1 or NEAT2 (nuclear-enriched abundant transcript…”
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Benchmarking the predictive capability of hydrological models for river flow and flood peak predictions across over 1000 catchments in Great Britain by Lane, Rosanna A, Coxon, Gemma, Freer, Jim E, Wagener, Thorsten, Johnes, Penny J, Bloomfield, John P, Greene, Sheila, Macleod, Christopher J. A, Reaney, Sim M

“…Benchmarking model performance across large samples of catchments is useful to guide model selection and future model development. Given uncertainties in the…”
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Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss by Arun, Gayatri, Diermeier, Sarah, Akerman, Martin, Chang, Kung-Chi, Wilkinson, J Erby, Hearn, Stephen, Kim, Youngsoo, MacLeod, A Robert, Krainer, Adrian R, Norton, Larry, Brogi, Edi, Egeblad, Mikala, Spector, David L

“…Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the…”
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From local to nonlocal: higher fidelity simulations of photon emission in intense laser pulses by Blackburn, T G, MacLeod, A J, King, B.

“…Abstract State-of-the-art numerical simulations of quantum electrodynamical (QED) processes in strong laser fields rely on a semiclassical combination of…”
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Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target by Ningarhari, Massih, Caruso, Stefano, Hirsch, Théo Z., Bayard, Quentin, Franconi, Andrea, Védie, Anne-Laure, Noblet, Bénédicte, Blanc, Jean-Frédéric, Amaddeo, Giuliana, Ganne, Nathalie, Ziol, Marianne, Paradis, Valérie, Guettier, Catherine, Calderaro, Julien, Morcrette, Guillaume, Kim, Youngsoo, MacLeod, A. Robert, Nault, Jean-Charles, Rebouissou, Sandra, Zucman-Rossi, Jessica

“…Telomerase activation is the earliest event in hepatocellular carcinoma (HCC) development. Thus, we aimed to elucidate the role of telomere length maintenance…”
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RNA Therapeutics in Oncology: Advances, Challenges, and Future Directions by MacLeod, A. Robert, Crooke, Stanley T.

“…RNA‐based therapeutic technologies represent a rapidly expanding class of therapeutic opportunities with the power to modulate cellular biology in ways never…”
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Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability by Heitger, Marcus H., Jones, Richard D., Macleod, A. D., Snell, Deborah L., Frampton, Chris M., Anderson, Tim J.

“…Post-concussion syndrome (PCS) can affect up to 20%–30% of patients with mild closed head injury (mCHI), comprising incomplete recovery and debilitating…”
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Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease by Baker, Sarah K., Chen, Zu-Lin, Norris, Erin H., Revenko, Alexey S., MacLeod, A. Robert, Strickland, Sidney

“…Two of the most predominant features of the Alzheimer’s disease (AD) brain are deposition of β-amyloid (Aβ) plaques and inflammation. The mechanism behind…”
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Targeting Long Noncoding RNA with Antisense Oligonucleotide Technology as Cancer Therapeutics by Zhou, Tianyuan, Kim, Youngsoo, MacLeod, A Robert

“…Recent annotation of the human transcriptome revealed that only 2 % of the genome encodes proteins while the majority of human genome is transcribed into…”
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RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk by MacLeod, David A., Rhinn, Herve, Kuwahara, Tomoki, Zolin, Ari, Di Paolo, Gilbert, McCabe, Brian D., Marder, Karen S., Honig, Lawrence S., Clark, Lorraine N., Small, Scott A., Abeliovich, Asa

“…Recent genome-wide association studies have linked common variants in the human genome to Parkinson’s disease (PD) risk. Here we show that the consequences of…”
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Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy by MacLeod, A Kenneth, Lin, De, Huang, Jeffrey T-J, McLaughlin, Lesley A, Henderson, Colin J, Wolf, C Roland

“…Osimertinib is a third-generation inhibitor of the epidermal growth factor receptor used in treatment of non-small cell lung cancer. A full understanding of…”
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Symonds on fear and Post Traumatic Stress Disorder (PTSD) by Sandy Macleod, A D

“…Prominent English neurologist Sir Charles Symonds, during World War II service with the Royal Air Force, published a series of articles emphasizing the role of…”
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A single fast radio burst localized to a massive galaxy at cosmological distance by Bannister, K W, Deller, A T, Phillips, C, Macquart, J-P, Prochaska, J X, Tejos, N, Ryder, S D, Sadler, E M, Shannon, R M, Simha, S, Day, C K, McQuinn, M, North-Hickey, F O, Bhandari, S, Arcus, W R, Bennert, V N, Burchett, J, Bouwhuis, M, Dodson, R, Ekers, R D, Farah, W, Flynn, C, James, C W, Kerr, M, Lenc, E, Mahony, E K, O'Meara, J, Osłowski, S, Qiu, H, Treu, T, U, V, Bateman, T J, Bock, D C-J, Bolton, R J, Brown, A, Bunton, J D, Chippendale, A P, Cooray, F R, Cornwell, T, Gupta, N, Hayman, D B, Kesteven, M, Koribalski, B S, MacLeod, A, McClure-Griffiths, N M, Neuhold, S, Norris, R P, Pilawa, M A, Qiao, R-Y, Reynolds, J, Roxby, D N, Shimwell, T W, Voronkov, M A, Wilson, C D

“…Fast radio bursts (FRBs) are brief radio emissions from distant astronomical sources. Some are known to repeat, but most are single bursts. Nonrepeating FRB…”
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Targeting nuclear RNA for in vivo correction of myotonic dystrophy by Wheeler, Thurman M., Leger, Andrew J., Pandey, Sanjay K., MacLeod, A. Robert, Nakamori, Masayuki, Cheng, Seng H., Wentworth, Bruce M., Bennett, C. Frank, Thornton, Charles A.

“…Nuclear-retained transcripts containing expanded repeats are shown to be sensitive to antisense silencing, and in a transgenic mouse model of myotonic…”
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Visual adaptation and face perception by Webster, Michael A., MacLeod, Donald I. A.

“…The appearance of faces can be strongly affected by the characteristics of faces viewed previously. These perceptual after-effects reflect processes of sensory…”
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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells by Shastri, Aditi, Choudhary, Gaurav, Teixeira, Margarida, Gordon-Mitchell, Shanisha, Ramachandra, Nandini, Bernard, Lumie, Bhattacharyya, Sanchari, Lopez, Robert, Pradhan, Kith, Giricz, Orsolya, Ravipati, Goutham, Wong, Li-Fan, Cole, Sally, Bhagat, Tushar D, Feld, Jonathan, Dhar, Yosman, Bartenstein, Matthias, Thiruthuvanathan, Victor J, Wickrema, Amittha, Ye, B Hilda, Frank, David A, Pellagatti, Andrea, Boultwood, Jacqueline, Zhou, Tianyuan, Kim, Youngsoo, MacLeod, A Robert, Epling-Burnette, P K, Ye, Minwei, McCoon, Patricia, Woessner, Richard, Steidl, Ulrich, Will, Britta, Verma, Amit

“…Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional…”
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Motor complications in an incident Parkinson's disease cohort by Scott, N. W., Macleod, A. D., Counsell, C. E.

“…Background and purpose Levodopa treatment in Parkinson's disease (PD) causes motor fluctuations and dyskinesias, but few data describe their development or…”
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The LL-100 panel: 100 cell lines for blood cancer studies by Quentmeier, Hilmar, Pommerenke, Claudia, Dirks, Wilhelm G., Eberth, Sonja, Koeppel, Max, MacLeod, Roderick A. F., Nagel, Stefan, Steube, Klaus, Uphoff, Cord C., Drexler, Hans G.

“…For many years, immortalized cell lines have been used as model systems for cancer research. Cell line panels were established for basic research and drug…”
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Detailing Köppen–Geiger climate zones at sub‐national to continental scale: a resource for pest risk analysis by MacLeod, A., Korycinska, A.

“…The widely used Köppen–Geiger climate classification system can inform judgements of establishment during pest categorizations and systems of simplified pest…”
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