Search Results - "MacLean P. Nasrallah"

Molecular and clinicopathologic features of gliomas harboring NTRK fusions by Torre, Matthew, Vasudevaraja, Varshini, Serrano, Jonathan, DeLorenzo, Michael, Malinowski, Seth, Blandin, Anne-Florence, Pages, Melanie, Ligon, Azra H, Dong, Fei, Meredith, David M, Nasrallah, MacLean P, Horbinski, Craig, Dahiya, Sonika, Ligon, Keith L, Santi, Mariarita, Ramkissoon, Shakti H, Filbin, Mariella G, Snuderl, Matija, Alexandrescu, Sanda

“…Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in ≤2% of gliomas and can promote gliomagenesis. The remarkable therapeutic…”
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Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma by Aubin, Rachael G., Troisi, Emma C., Montelongo, Javier, Alghalith, Adam N., Nasrallah, Maclean P., Santi, Mariarita, Camara, Pablo G.

“…Pediatric ependymoma is a devastating brain cancer marked by its relapsing pattern and lack of effective chemotherapies. This shortage of treatments is due to…”
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Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach by Guo, Jun, Fathi Kazerooni, Anahita, Toorens, Erik, Akbari, Hamed, Yu, Fanyang, Sako, Chiharu, Mamourian, Elizabeth, Shinohara, Russell T., Koumenis, Constantinos, Bagley, Stephen J., Morrissette, Jennifer J. D., Binder, Zev A., Brem, Steven, Mohan, Suyash, Lustig, Robert A., O’Rourke, Donald M., Ganguly, Tapan, Bakas, Spyridon, Nasrallah, MacLean P., Davatzikos, Christos

“…Glioblastoma is a highly heterogeneous disease, with variations observed at both phenotypical and molecular levels. Personalized therapies would be facilitated…”
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Validation of multiparametric MRI based prediction model in identification of pseudoprogression in glioblastomas by de Godoy, Laiz Laura, Mohan, Suyash, Wang, Sumei, Nasrallah, MacLean P, Sakai, Yu, O'Rourke, Donald M, Bagley, Stephen, Desai, Arati, Loevner, Laurie A, Poptani, Harish, Chawla, Sanjeev

“…Accurate differentiation of pseudoprogression (PsP) from tumor progression (TP) in glioblastomas (GBMs) is essential for appropriate clinical management and…”
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Intraoperative cytology of pituicytomas by Viaene, Angela N., Lee, Edward B., Nasrallah, MacLean P.

“…Background Pituicytoma is a rare tumor of the sella and suprasellar region. It is common for these tumors to be misdiagnosed radiographically as pituitary…”
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Clinical Evaluation of IDH Mutation Status in Formalin-Fixed Paraffin-Embedded Tissue in Gliomas by Nelson, Ernest J., Gubbiotti, Maria A., Carlin, Alicia M., Nasrallah, MacLean P., Van Deerlin, Vivianna M., Herlihy, Sarah E.

“…Background and Objective Determination of isocitrate dehydrogenase (IDH) 1/2 mutational status is crucial for a glioma diagnosis. It is common for IDH…”
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Histologic, immunohistochemical, and molecular features of pituicytomas and atypical pituicytomas by Viaene, Angela N, Lee, Edward B, Rosenbaum, Jason N, Nasrallah, Ilya M, Nasrallah, MacLean P

“…Pituicytoma is a rare, poorly characterized tumor of the sellar region that is thought to be derived from neurohypophyseal pituicytes. Resection of…”
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Accurate and Robust Alignment of Differently Stained Histologic Images Based on Greedy Diffeomorphic Registration by Venet, Ludovic, Pati, Sarthak, Feldman, Michael D, Nasrallah, MacLean P, Yushkevich, Paul, Bakas, Spyridon

“…Histopathologic assessment routinely provides rich microscopic information about tissue structure and disease process. However, the sections used are very…”
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SETD2 mutations in primary central nervous system tumors by Viaene, Angela N, Santi, Mariarita, Rosenbaum, Jason, Li, Marilyn M, Surrey, Lea F, Nasrallah, MacLean P

“…Mutations in SETD2 are found in many tumors, including central nervous system (CNS) tumors. Previous work has shown these mutations occur specifically in high…”
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Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR -mutant glioblastoma by Makhlin, Igor, Salinas, Ryan D, Zhang, Daniel, Jacob, Fadi, Ming, Gou-Li, Song, Hongjun, Saxena, Deeksha, Dorsey, Jay F, Nasrallah, MacLean P, Morrissette, Jennifer Jd, Binder, Zev A, O'Rourke, Donald M, Desai, Arati S, Brem, Steven, Bagley, Stephen J

“…Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and carries a dismal prognosis. The gene is among the most commonly deranged…”
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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma by O'Rourke, Donald M, Nasrallah, MacLean P, Desai, Arati, Melenhorst, Jan J, Mansfield, Keith, Morrissette, Jennifer J D, Martinez-Lage, Maria, Brem, Steven, Maloney, Eileen, Shen, Angela, Isaacs, Randi, Mohan, Suyash, Plesa, Gabriela, Lacey, Simon F, Navenot, Jean-Marc, Zheng, Zhaohui, Levine, Bruce L, Okada, Hideho, June, Carl H, Brogdon, Jennifer L, Maus, Marcela V

“…We conducted a first-in-human study of intravenous delivery of a single dose of autologous T cells redirected to the epidermal growth factor receptor variant…”
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Molecular classification and grading of meningioma by Nasrallah, MacLean P., Aldape, Kenneth D.

“…Purpose Meningiomas are the most common primary intracranial tumor in older adults (Ostrom et al. in Neuro Oncol 21(Suppl 5):v1–v100, 2019). Treatment is…”
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Glioma progression is shaped by genetic evolution and microenvironment interactions by Varn, Frederick S., Johnson, Kevin C., Martinek, Jan, Huse, Jason T., Wesseling, Pieter, Cooper, Lee A.D., Malta, Tathiane M., Wade, Taylor E., Brat, Daniel, Aldape, Kenneth, Ismail, Azzam, Kim, Hoon, White, Kieron, Pollock, Steven, Goldfarb, Christine, Lee, Ga-Hyun, Anderson, Kevin J., Nehar-Belaid, Djamel, Bakas, Spyridon, Byrne, Annette T., D’Angelo, Fulvio, Gan, Hui K., Khasraw, Mustafa, Migliozzi, Simona, Paek, Sun Ha, Walenkamp, Annemiek M.E., Weiss, Tobias, Poisson, Laila M., Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel G.W., Varn, Frederick S., Huse, Jason T., Nasrallah, MacLean P., Wesseling, Pieter, Cooper, Lee A.D., Malta, Tathiane M., Sabedot, Thais S., Brat, Daniel, Gould, Peter V., Aldape, Kenneth, Sivajothi, Santhosh K., Barthel, Floris P., Kocakavuk, Emre, Ahmed, Nazia, White, Kieron, Moon, Hyo-Eun, Pollock, Steven, Lee, Ga-Hyun, Garofano, Luciano, Anderson, Kevin J., Nehar-Belaid, Djamel, Barnholtz-Sloan, Jill S., Bakas, Spyridon, Byrne, Annette T., Gan, Hui K., Khasraw, Mustafa, Ryan Ormond, D., Ha Paek, Sun, Van Meir, Erwin G., Walenkamp, Annemiek M.E., Watts, Colin, Weiss, Tobias, Weller, Michael, Amin, Samirkumar B., Brodbelt, Andrew, Bulsara, Ketan R., Castro, Ana Valeria, Connelly, Jennifer M., Costello, Joseph F., Finocchiaro, Gaetano, French, Pim J., Hau, Ann C., Hong, Chibo, Horbinski, Craig, Kannan, Kasthuri S., Kouwenhoven, Mathilde CM, LaViolette, Peter S., Ligon, Keith L., Lowman, Allison K., Miletic, Hrvoje, Niers, Johanna M., Phillips, Joanna J., Rabadan, Raul, Rao, Ganesh, Reifenberger, Guido, Sanai, Nader, Short, Susan C., Suzuki, Hiromichi, Tabatabai, Ghazaleh, Tomaszewski, William H., Wells, Michael, Wheeler, Helen, Xie, Jichun, Alfred Yung, W.K., Zadeh, Gelareh, Poisson, Laila M., Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel GW

“…The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed…”
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Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma by Nasrallah, MacLean P., Binder, Zev A., Oldridge, Derek A., Zhao, Jianhua, Lieberman, David B., Roth, Jacquelyn J., Watt, Christopher D., Sukhadia, Shrey, Klinman, Eva, Daber, Robert D., Desai, Arati, Brem, Steven, O’Rourke, Donald M., Morrissette, Jennifer J. D.

“…Molecular profiling of glioblastoma has revealed complex cytogenetic, epigenetic, and molecular abnormalities that are necessary for diagnosis, prognosis, and…”
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Neuropathology associated with SARS-CoV-2 infection by Nasrallah, MacLean P, Mourelatos, Zissimos, Lee, Edward B

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Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1 by Rathore, Saima, Akbari, Hamed, Rozycki, Martin, Abdullah, Kalil G., Nasrallah, MacLean P., Binder, Zev A., Davuluri, Ramana V., Lustig, Robert A., Dahmane, Nadia, Bilello, Michel, O’Rourke, Donald M., Davatzikos, Christos

“…The remarkable heterogeneity of glioblastoma, across patients and over time, is one of the main challenges in precision diagnostics and treatment planning…”
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Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations by Cho, Ginam, Nasrallah, MacLean P., Lim, Youngshin, Golden, Jeffrey A.

“…Mutations in the Aristaless-related homeobox gene ( ARX ) are associated with a wide variety of neurologic disorders including lissencephaly, hydrocephaly,…”
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Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results by Bagley, Stephen J., Logun, Meghan, Fraietta, Joseph A., Wang, Xin, Desai, Arati S., Bagley, Linda J., Nabavizadeh, Ali, Jarocha, Danuta, Martins, Rene, Maloney, Eileen, Lledo, Lester, Stein, Carly, Marshall, Amy, Leskowitz, Rachel, Jadlowsky, Julie K., Christensen, Shannon, Oner, Bike Su, Plesa, Gabriela, Brennan, Andrea, Gonzalez, Vanessa, Chen, Fang, Sun, Yusha, Gladney, Whitney, Barrett, David, Nasrallah, MacLean P., Hwang, Wei-Ting, Ming, Guo-Li, Song, Hongjun, Siegel, Donald L., June, Carl H., Hexner, Elizabeth O., Binder, Zev A., O’Rourke, Donald M.

“…Recurrent glioblastoma (rGBM) remains a major unmet medical need, with a median overall survival of less than 1 year. Here we report the first six patients…”
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Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors by Yin, Yibo, Rodriguez, Jesse L., Li, Nannan, Thokala, Radhika, Nasrallah, MacLean P., Hu, Li, Zhang, Logan, Zhang, Jiasi Vicky, Logun, Meghan T., Kainth, Devneet, Haddad, Leila, Zhao, Yang, Wu, Tong, Johns, Emily X., Long, Yu, Liang, Hongsheng, Qi, Jiping, Zhang, Xiangtong, Binder, Zev A., Lin, Zhiguo, O’Rourke, Donald M.

“…Bispecific T cell engagers (BiTEs) are bispecific antibodies that redirect T cells to target antigen-expressing tumors. We hypothesized that BiTE-secreting…”
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Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development by Binder, Zev A., Thorne, Amy Haseley, Bakas, Spyridon, Wileyto, E. Paul, Bilello, Michel, Akbari, Hamed, Rathore, Saima, Ha, Sung Min, Zhang, Logan, Ferguson, Cole J., Dahiya, Sonika, Bi, Wenya Linda, Reardon, David A., Idbaih, Ahmed, Felsberg, Joerg, Hentschel, Bettina, Weller, Michael, Bagley, Stephen J., Morrissette, Jennifer J.D., Nasrallah, MacLean P., Ma, Jianhui, Zanca, Ciro, Scott, Andrew M., Orellana, Laura, Davatzikos, Christos, Furnari, Frank B., O'Rourke, Donald M.

“…We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment…”
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