Search Results - "MacLean, S."

NIH working group report: Innovative research to improve maintenance of weight loss by MacLean, Paul S., Wing, Rena R., Davidson, Terry, Epstein, Leonard, Goodpaster, Bret, Hall, Kevin D., Levin, Barry E., Perri, Michael G., Rolls, Barbara J., Rosenbaum, Michael, Rothman, Alexander J., Ryan, Donna

“…Objectives The National Institutes of Health, led by the National Heart, Lung, and Blood Institute, organized a working group of experts to discuss the problem…”
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role for adipose tissue in weight regain after weight loss by MacLean, P. S, Higgins, J. A, Giles, E. D, Sherk, V. D, Jackman, M. R

“…Weight regain after weight loss is a substantial challenge in obesity therapeutics. Dieting leads to significant adaptations in the homeostatic system that…”
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High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism by Lanaspa, Miguel A., Kuwabara, Masanari, Andres-Hernando, Ana, Li, Nancy, Cicerchi, Christina, Jensen, Thomas, Orlicky, David J., Roncal-Jimenez, Carlos A., Ishimoto, Takuji, Nakagawa, Takahiko, Rodriguez-Iturbe, Bernardo, MacLean, Paul S., Johnson, Richard J.

“…Dietary guidelines for obesity typically focus on three food groups (carbohydrates, fat, and protein) and caloric restriction. Intake of noncaloric nutrients,…”
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Biology's response to dieting: the impetus for weight regain by Maclean, Paul S, Bergouignan, Audrey, Cornier, Marc-Andre, Jackman, Matthew R

“…Dieting is the most common approach to losing weight for the majority of obese and overweight individuals. Restricting intake leads to weight loss in the short…”
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Biological control of appetite: A daunting complexity by MacLean, Paul S., Blundell, John E., Mennella, Julie A., Batterham, Rachel L.

“…Objective This review summarizes a portion of the discussions of an NIH Workshop (Bethesda, MD, 2015) titled “Self‐Regulation of Appetite—It's Complicated,”…”
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Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects by Kuwabara, Masanari, Kuwabara, Remi, Niwa, Koichiro, Hisatome, Ichiro, Smits, Gerard, Roncal-Jimenez, Carlos A, MacLean, Paul S, Yracheta, Joseph M, Ohno, Minoru, Lanaspa, Miguel A, Johnson, Richard J, Jalal, Diana I

“…Obesity is a risk factor for hypertension, diabetes mellitus (DM), dyslipidemia, and hyperuricemia. Here, we evaluated whether the same body mass index (BMI)…”
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Heritability estimates of methane emissions from sheep by Pinares-Patiño, C. S., Hickey, S. M., Young, E. A., Dodds, K. G., MacLean, S., Molano, G., Sandoval, E., Kjestrup, H., Harland, R., Hunt, C., Pickering, N. K., McEwan, J. C.

“…The objective of this study was to determine the genetic parameters of methane (CH4) emissions and their genetic correlations with key production traits. The…”
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Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease[S] by McManaman, James L., Bales, Elise S., Orlicky, David J., Jackman, Matthew, MacLean, Paul S., Cain, Shannon, Crunk, Amanda E., Mansur, Ayla, Graham, Christine E., Bowman, Thomas A., Greenberg, Andrew S.

“…The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple nonadipose tissues, where it is thought to play a role in regulating…”
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Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice by Ishimoto, Takuji, Lanaspa, Miguel A, Le, MyPhuong T, Garcia, Gabriela E, Diggle, Christine P, MacLean, Paul S, Jackman, Matthew R, Asipu, Aruna, Roncal-Jimenez, Carlos A, Kosugi, Tomoki, Rivard, Christopher J, Maruyama, Shoichi, Rodriguez-Iturbe, Bernardo, Sánchez-Lozada, Laura G, Bonthron, David T, Sautin, Yuri Y, Johnson, Richard J

“…Fructose intake from added sugars correlates with the epidemic rise in obesity, metabolic syndrome, and nonalcoholic fatty liver disease. Fructose intake also…”
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Tackling gambling harm to bingo players at a time of commercial, regulatory and technological change – towards a public health approach by Maltzahn, K., Whiteside, M., Lee, H., Cox, J., MacLean, S.

“…The aim of this paper is to identify possible regulatory, policy and program measures to address gambling harm to bingo players and their communities, and in…”
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Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer by Giles, Erin D, Jindal, Sonali, Wellberg, Elizabeth A, Schedin, Troy, Anderson, Steven M, Thor, Ann D, Edwards, Dean P, MacLean, Paul S, Schedin, Pepper

“…Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for…”
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Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI by Rudolph, M C, Young, B E, Lemas, D J, Palmer, C E, Hernandez, T L, Barbour, L A, Friedman, J E, Krebs, N F, MacLean, P S

“…Background/Objectives: Excessive infant weight gain in the first 6-month of life is a powerful predictor of childhood obesity and related health risks. In…”
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Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature by Strohacker, K, McCaffery, J M, MacLean, P S, Wing, R R

“…Numerous laboratory studies involving both animal and human models indicate that weight loss induces changes in leptin, ghrelin and insulin sensitivity, which…”
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The Gut Microbiota during a Behavioral Weight Loss Intervention by Stanislawski, Maggie A, Frank, Daniel N, Borengasser, Sarah J, Ostendorf, Danielle M, Ir, Diana, Jambal, Purevsuren, Bing, Kristen, Wayland, Liza, Siebert, Janet C, Bessesen, Daniel H, MacLean, Paul S, Melanson, Edward L, Catenacci, Victoria A

“…Altered gut microbiota has been linked to obesity and may influence weight loss. We are conducting an ongoing weight loss trial, comparing daily caloric…”
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Combination Nivolumab, CD137 Agonism, and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma by Hall, MacLean S, Mullinax, John E, Cox, Cheryl A, Hall, Amy M, Beatty, Matthew S, Blauvelt, Jamie, Innamarato, Patrick, Nagle, Luz, Branthoover, Holly, Wiener, Doris, Schachner, Benjamin, Martinez, Alberto J, Richards, Allison D, Rich, Carolyn J, Colón Colón, Marjorie, Schell, Michael J, Teer, Jamie K, Khushalani, Nikhil I, Weber, Jeffrey S, Mulé, James J, Sondak, Vernon K, Pilon-Thomas, Shari, Sarnaik, Amod A

“…Metastatic melanoma is a tumor amenable to immunotherapy in part due to the presence of antigen-specific tumor-infiltrating lymphocytes (TIL). These T cells…”
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Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer by Wellberg, Elizabeth A, Corleto, Karen A, Checkley, L Allyson, Jindal, Sonali, Johnson, Ginger, Higgins, Janine A, Obeid, Sarina, Anderson, Steven M, Thor, Ann D, Schedin, Pepper J, MacLean, Paul S, Giles, Erin D

“…Obesity and adult weight gain are linked to increased breast cancer risk and poorer clinical outcomes in postmenopausal women, particularly for…”
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Phase Ib trial of IRX-2 plus durvalumab in patients with recurrent and/or metastatic head and neck squamous cell carcinoma by Park, Robin, Li, Jiannong, Slebos, Robbert J.C., Chaudhary, Ritu, Poole, Maria I., Ferraris, Carina, Farinhas, Joaquim, Hernandez-Prera, Juan, Kirtane, Kedar, Teer, Jamie K., Song, Xiaofei, Hall, MacLean S., Tasoulas, Jason, Amelio, Antonio L., Chung, Christine H.

“…•Combined IRX-2 and durvalumab has manageable toxicities.•Combined IRX-2 and durvalumab increased PD-L1 expression and increased number of tumor-infiltrating…”
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Optimal Duration of Antibiotics Following Appendectomy for Patients With Complicated Appendicitis by Panshin, Maclean S, Alnachoukati, Omar K, Schroeppel, Thomas J, Metzler, Michael, McFann, Kim, Dunn, Julie A

“…Complicated appendicitis patients typically undergo appendectomy followed by antibiotics. The optimal course of antibiotics for complicated appendicitis is…”
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Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle by Perreault, Leigh, Newsom, Sean A, Strauss, Allison, Kerege, Anna, Kahn, Darcy E, Harrison, Kathleen A, Snell-Bergeon, Janet K, Nemkov, Travis, D'Alessandro, Angelo, Jackman, Matthew R, MacLean, Paul S, Bergman, Bryan C

“…Accumulation of diacylglycerol (DAG) and sphingolipids is thought to promote skeletal muscle insulin resistance by altering cellular signaling specific to…”
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Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice by Song 宋志林, Zhilin, Roncal-Jimenez, Carlos A, Lanaspa-Garcia, Miguel A, Oppelt, Sarah A, Kuwabara, Masanari, Jensen, Thomas, Milagres, Tamara, Andres-Hernando, Ana, Ishimoto, Takuji, Garcia, Gabriela E, Johnson, Ginger, MacLean, Paul S, Sanchez-Lozada, Laura-Gabriela, Tolan, Dean R, Johnson, Richard J

“…Fructose stimulates vasopressin in humans and can be generated endogenously by activation of the polyol pathway with hyperosmolarity. We hypothesized that…”
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