Search Results - "MacLaurin, Jason G."

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program by Khacho, Mireille, Clark, Alysen, Svoboda, Devon S., Azzi, Joelle, MacLaurin, Jason G., Meghaizel, Cynthia, Sesaki, Hiromi, Lagace, Diane C., Germain, Marc, Harper, Mary-Ellen, Park, David S., Slack, Ruth S.

“…Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion and aging. While mitochondrial morphology plays a fundamental role in…”
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OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand by Patten, David A, Wong, Jacob, Khacho, Mireille, Soubannier, Vincent, Mailloux, Ryan J, Pilon-Larose, Karine, MacLaurin, Jason G, Park, David S, McBride, Heidi M, Trinkle-Mulcahy, Laura, Harper, Mary-Ellen, Germain, Marc, Slack, Ruth S

“…Cristae, the organized invaginations of the mitochondrial inner membrane, respond structurally to the energetic demands of the cell. The mechanism by which…”
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The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity by Jahani-Asl, Arezu, Pilon-Larose, Karine, Xu, William, MacLaurin, Jason G., Park, David S., McBride, Heidi M., Slack, Ruth S.

“…Mitochondrial dynamics have been extensively studied in the context of classical cell death models involving Bax-mediated cytochrome c release. Excitotoxic…”
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Mitofusin 2 Protects Cerebellar Granule Neurons against Injury-induced Cell Death by Jahani-Asl, Arezu, Cheung, Eric C.C., Neuspiel, Margaret, MacLaurin, Jason G., Fortin, Andre, Park, David S., McBride, Heidi M., Slack, Ruth S.

“…Of the GTPases involved in the regulation of the fusion machinery, mitofusin 2 (Mfn2) plays an important role in the nervous system as point mutations of this…”
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Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis by Cheung, Eric CC, Joza, Nicholas, Steenaart, Nancy AE, McClellan, Kelly A, Neuspiel, Margaret, McNamara, Stephen, MacLaurin, Jason G, Rippstein, Peter, Park, David S, Shore, Gordon C, McBride, Heidi M, Penninger, Josef M, Slack, Ruth S

“…The mitochondrial protein apoptosis‐inducing factor (AIF) translocates to the nucleus and induces apoptosis. Recent studies, however, have indicated the…”
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Apoptosis-Inducing Factor Is Involved in the Regulation of Caspase-Independent Neuronal Cell Death by Cregan, Sean P., Fortin, Andre, MacLaurin, Jason G., Callaghan, Steven M., Cecconi, Francesco, Yu, Seong-Woon, Dawson, Ted M., Dawson, Valina L., Park, David S., Kroemer, Guido, Slack, Ruth S.

“…Caspase-independent death mechanisms have been shown to execute apoptosis in many types of neuronal injury. P53 has been identified as a key regulator of…”
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Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis by Khacho, Mireille, Clark, Alysen, Svoboda, Devon S, MacLaurin, Jason G, Lagace, Diane C, Park, David S, Slack, Ruth S

“…Mitochondrial dysfunction is a common feature of many genetic disorders that target the brain and cognition. However, the exact role these organelles play in…”
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Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons by Cregan, Sean P, MacLaurin, Jason G, Craig, Constance G, Robertson, George S, Nicholson, Donald W, Park, David S, Slack, Ruth S

“…p53 is a pivotal molecule regulating the death of neurons both after acute injury and during development. The molecular mechanisms by which p53 induces…”
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APAF1 Is a Key Transcriptional Target for p53 in the Regulation of Neuronal Cell Death by Fortin, Andre, Cregan, Sean P., MacLaurin, Jason G., Kushwaha, Neena, Hickman, Emma S., Thompson, Charlie S., Hakim, Antoine, Albert, Paul R., Cecconi, Francesco, Helin, Kristian, Park, David S., Slack, Ruth S.

“…p53 is a transcriptional activator which has been implicated as a key regulator of neuronal cell death after acute injury. We have shown previously that…”
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p53 Activation Domain 1 Is Essential for PUMA Upregulation and p53-Mediated Neuronal Cell Death by Cregan, Sean P, Arbour, Nicole A, MacLaurin, Jason G, Callaghan, Steven M, Fortin, Andre, Cheung, Eric C. C, Guberman, Daniel S, Park, David S, Slack, Ruth S

“…The p53 tumor suppressor gene has been implicated in the regulation of apoptosis in a number of different neuronal death paradigms. Because of the importance…”
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The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1 by Fortin, Andre, MacLaurin, Jason G, Arbour, Nicole, Cregan, Sean P, Kushwaha, Neena, Callaghan, Steven M, Park, David S, Albert, Paul R, Slack, Ruth S

“…The p53 tumor suppressor gene is believed to play an important role in neuronal cell death in acute neurological disease and in neurodegeneration. The p53…”
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Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival by Khacho, Mireille, Tarabay, Michelle, Patten, David, Khacho, Pamela, MacLaurin, Jason G., Guadagno, Jennifer, Bergeron, Richard, Cregan, Sean P., Harper, Mary-Ellen, Park, David S., Slack, Ruth S.

“…Sustained cellular function and viability of high-energy demanding post-mitotic cells rely on the continuous supply of ATP. The utilization of mitochondrial…”
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Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate by Vanderluit, Jacqueline L, Wylie, Crystal A, McClellan, Kelly A, Ghanem, Noel, Fortin, Andre, Callaghan, Steve, MacLaurin, Jason G, Park, David S, Slack, Ruth S

“…The Retinoblastoma protein p107 regulates the neural precursor pool in both the developing and adult brain. As p107-deficient mice exhibit enhanced levels of…”
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Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development by Ferguson, Kerry L., Vanderluit, Jacqueline L., Hébert, Jean M., McIntosh, W.C., Tibbo, Emma, MacLaurin, Jason G., Park, David S., Wallace, Valerie A., Vooijs, Marc, McConnell, Susan K., Slack, Ruth S.

“…Correct cell cycle regulation and terminal mitosis are critical for nervous system development. The retinoblastoma (Rb) protein is a key regulator of these…”
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Caspase 3 Deficiency Rescues Peripheral Nervous System Defect in Retinoblastoma Nullizygous Mice by Simpson, Matthew T. W, MacLaurin, Jason G, Xu, Daigen, Ferguson, Kerry L, Vanderluit, Jacqueline L, Davoli, Maria A, Roy, Sophie, Nicholson, Donald W, Robertson, George S, Park, David S, Slack, Ruth S

“…The retinoblastoma tumor suppressor protein, pRb, is a key regulator of cell cycle and has been implicated in the terminal differentiation of neuronal cells…”
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Apoptosis-inducing factor is involved in the regulation of captase-independent neuronal cell death by Cregan, Sean P, tin, Andre, MacLaurin, Jason G, Callaghan, Steven M

“…Research results indicate that p53 can induce neuronal cell death via a caspase-mediated process activated by apoptotic activating factor-1 and via a delayed…”
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