Search Results - "MacKinnon, Colin"

Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin‑2 Inducible T‑Cell Kinase (ITK) Inhibitors by Heifetz, Alexander, Trani, Giancarlo, Aldeghi, Matteo, MacKinnon, Colin H, McEwan, Paul A, Brookfield, Frederick A, Chudyk, Ewa I, Bodkin, Mike, Pei, Zhonghua, Burch, Jason D, Ortwine, Daniel F

“…Inhibition of inducible T-cell kinase (ITK), a nonreceptor tyrosine kinase, may represent a novel treatment for allergic asthma. In our previous reports, we…”
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Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors by Burch, Jason D, Lau, Kevin, Barker, John J, Brookfield, Fred, Chen, Yong, Chen, Yuan, Eigenbrot, Charles, Ellebrandt, Claire, Ismaili, M. Hicham A, Johnson, Adam, Kordt, Daniel, MacKinnon, Colin H, McEwan, Paul A, Ortwine, Daniel F, Stein, Daniel B, Wang, Xiaolu, Winkler, Dirk, Yuen, Po-Wai, Zhang, Yamin, Zarrin, Ali A, Pei, Zhonghua

“…Interleukin-2 inducible T-cell kinase (ITK), a member of the Tec family of tyrosine kinases, plays a major role in T-cell signaling downstream of the T-cell…”
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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK) by Trani, Giancarlo, Barker, John J, Bromidge, Steven M, Brookfield, Frederick A, Burch, Jason D, Chen, Yuan, Eigenbrot, Charles, Heifetz, Alexander, Ismaili, M Hicham A, Johnson, Adam, Krülle, Thomas M, MacKinnon, Colin H, Maghames, Rosemary, McEwan, Paul A, Montalbetti, Christian A G N, Ortwine, Daniel F, Pérez-Fuertes, Yolanda, Vaidya, Darshan G, Wang, Xiaolu, Zarrin, Ali A, Pei, Zhonghua

“…Starting from benzylpyrimidine 2, molecular modeling and X-ray crystallography were used to design highly potent inhibitors of Interleukin-2 inducible T-cell…”
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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK) by MacKinnon, Colin H., Lau, Kevin, Burch, Jason D., Chen, Yuan, Dines, Jonathon, Ding, Xiao, Eigenbrot, Charles, Heifetz, Alexander, Jaochico, Allan, Johnson, Adam, Kraemer, Joachim, Kruger, Susanne, Krülle, Thomas M., Liimatta, Marya, Ly, Justin, Maghames, Rosemary, Montalbetti, Christian A.G.N., Ortwine, Daniel F., Pérez-Fuertes, Yolanda, Shia, Steven, Stein, Daniel B., Trani, Giancarlo, Vaidya, Darshan G., Wang, Xiaolu, Bromidge, Steven M., Wu, Lawren C., Pei, Zhonghua

“…Inhibition of the non-receptor tyrosine kinase ITK, a component of the T-cell receptor signalling cascade, may represent a novel treatment for allergic asthma…”
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Acridine derivatives activate p53 and induce tumor cell death through bax by Wang, Wenge, Ho, William C., Dicker, David T., MacKinnon, Colin, Winkler, Jeffrey D., Marmorstein, Ronen, El-Deiry, Wafik S.

“…CP-31398 activates wild-type p53 by a novel mechanism that does not involve phosphorylation of the amino-terminus of p53 and disassociation of MDM2. To…”
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Potent agonists of the Hedgehog signaling pathway by Brunton, Shirley A., Stibbard, John H.A., Rubin, Lee L., Guicherit, Oivin M., Kruse, Lawrence I., Price, Stephen, di Lucrezia, Raffaella, MacKinnon, Colin H., Avery, Alaric, Park, Yvonne, Buxton, Danielle, Boyd, Edward A

“…An SAR study for a family of substituted biaryls which led to 21k (EC50=0.3nm) is reported. A family of biaryl substituted 1,4-diaminocyclohexanamides of…”
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HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives by Wang, Guangyi, Lei, Huoxing, Wang, Xiaofang, Das, Debasis, Hong, Jian, Mackinnon, Colin H., Coulter, Thomas S., Montalbetti, Christian A.G.N., Mears, Richard, Gai, Xinjie, Bailey, Sarah E., Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Rajagopalan, P.T. Ravi, Cheng, Robert K.Y., Barker, John J., Felicetti, Brunella, Schönfeld, Dorian L., Stoycheva, Antitsa, Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid

“…Synthesis of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives and in vitro anti-HCV activity are…”
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Tandem Diels−Alder/Fragmentation Approach to the Synthesis of Eleutherobin by Winkler, Jeffrey D, Quinn, Kevin J, MacKinnon, Colin H, Hiscock, Steven D, McLaughlin, Emily C

“…A synthesis of 28, the carbon framework of the eleutherobin aglycone, is reported in a 15-step sequence from readily available starting materials. The tandem…”
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Alexander Gordon Mackinnon by Mackinnon, Colin

“…During part of his national service in the Royal Army Medical Corps, he was medical officer on the troop ship Empire Test, making journeys between Liverpool…”
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Enzymatic Synthesis of Monocyclic β-Lactams by Sleeman, Mark C, MacKinnon, Colin H, Hewitson ∗, Kirsty S, Schofield, Christopher J

“…An Mg 2+ and ATP dependent β-lactam synthetase (BLS) catalyses formation of a β-lactam ring during the biosynthesis of clavulanic acid, an important…”
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Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-Coenzyme A by Kershaw, Nadia J, Mukherji, Mridul, MacKinnon, Colin H, Claridge, Timothy D.W, Odell, Barbara, Wierzbicki, Anthony S, Lloyd, Matthew D, Schofield, Christopher J

“…Phytanoyl-CoA 2-hydroxylase (PAHX), an iron(II) and 2-oxoglutarate-dependent oxygenase, catalyses an essential step in the mammalian metabolism of β-methylated…”
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Cloning, expression, and purification of mammalian 4-hydroxyphenylpyruvate dioxygenase/alpha-ketoisocaproate dioxygenase by Crouch, N P, Lee, M H, Iturriagagoitia-Bueno, T, MacKinnon, C H

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Is Empathy Effective for Customer Service? Evidence From Call Center Interactions by Clark, Colin Mackinnon, Murfett, Ulrike Marianne, Rogers, Priscilla S., Ang, Soon

“…This study examines the nature and value of empathic communication in call center dyads. Our research site was a multinational financial services call center…”
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William Friedman's Bletchley park diary: A new source for the history of Anglo-American intelligence cooperation by Mackinnon, Colin

“…The great American cryptologist William F. Friedman along with two other colleagues visited Bletchley Park and other British code-breaking facilities in the…”
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Palestinian and Israeli economies buffeted by war's destruction, lost revenue by MacKinnon, Colin

“…A look at the US and the Israeli-Palestinian conflict is offered. The economies of both Israel and Palestine have been buffeted severely by what began as the…”
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Iran Moves Hesitantly Toward Liberalization by MacKinnon, Colin

“…"In early May [2001] Iran's parliament passed two measures in fast succession that are steps of a sort toward opening the country's economy to the rest of the…”
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Economic Costs of the Intifada Grow by MacKinnon, Colin

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Will the New Administration Formulate New Iran, Caspian Policies? by MacKinnon, Colin

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A mechanistic rationalisation for the substrate specificity of recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) by Crouch, Nicholas P., Adlington, Robert M., Baldwin, Jack E., Lee, Meng -Huee, MacKinnon, Colin H.

“…The isolation and purification of α-ketoisocaproate dioxygenase [α-KICD] from rat liver is described. Sequence determination of the purified protein revealed…”
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Effects of two-dimensional and three-dimensional forcing on molecular mixing in a two-stream shear layer by MacKinnon, Colin Gregor

“…It is well known that external 2-D perturbations at frequencies low compared to the natural roll-up frequency lead to enhanced growth rates in a two-stream…”
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