Search Results - "MacKenzie, Gerardo G"

EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines by Wei, Ran, Wirkus, Joanna, Yang, Zixuan, Machuca, Jazmin, Esparza, Yasmin, Mackenzie, Gerardo G.

“…Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea, presents anticancer efficacy. However, its exact mechanism of action is not…”
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Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives by Cortez, Natalia E., Mackenzie, Gerardo G.

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and extremely therapy-resistant cancer. It is estimated that up to 80% of PDAC patients present with…”
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Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan by Rodriguez Lanzi, Cecilia, Wei, Ran, Luo, Dingyuan, Mackenzie, Gerardo G.

“…Novel therapeutic strategies are needed in the fight against pancreatic cancer. We have previously documented the chemopreventive effect of MDC-22 in…”
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Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine by Wei, Ran, Penso, Natalia E Cortez, Hackman, Robert M, Wang, Yuefei, Mackenzie, Gerardo G

“…Most pancreatic cancers are usually diagnosed at an advanced stage when they have already metastasized. Epigallocatechin-3-gallate (EGCG), a major polyphenolic…”
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A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice by Cortez, Natalia E, Pathak, Suraj, Rodriguez Lanzi, Cecilia, Hong, Brian V, Crone, Ryman, Sule, Rasheed, Wang, Fangyi, Chen, Shuai, Gomes, Aldrin V, Baar, Keith, Mackenzie, Gerardo G

“…Cancer-associated cachexia (CAC) is a critical contributor to pancreatic ductal adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new…”
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Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice by Mackenzie, Gerardo G, Huang, Liqun, Alston, Ninche, Ouyang, Nengtai, Vrankova, Kvetoslava, Mattheolabakis, George, Constantinides, Panayiotis P, Rigas, Basil

“…New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid…”
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Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox‐regulated mechanisms by Queisser, Nina, Schupp, Nicole, Schwarz, Eva, Hartmann, Christina, Mackenzie, Gerardo G., Oteiza, Patricia I.

“…Epidemiological studies found an increased risk for kidney cancer in hypertensive patients, of which a subgroup has high aldosterone (Ald) levels. We recently…”
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A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain by Mackenzie, Gerardo G., Salvador, Gabriela A., Romero, Carolina, Keen, Carl L., Oteiza, Patricia I.

“…Zinc (Zn) deficiency during early development can result in multiple brain abnormalities and altered neuronal functions. In rats, a gestational deficit of Zn…”
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Zinc, oxidant-triggered cell signaling, and human health by Oteiza, Patricia I., Mackenzie, Gerardo G.

“…Zinc (Zn) deficiency, a frequent condition in human populations, induces oxidative stress and subsequently activates/inhibits oxidant-sensitive transcription…”
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Liposomal Irinotecan in the Treatment of Refractory Pancreatic Cancer by Bien, Harold, Mackenzie, Gerardo G, Choi, Minsig

“…Effective therapies against metastatic pancreatic cancer remain limited, and despite treatment, many will ultimately progress. Previously, few options were…”
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The Role of Zinc in the Modulation of Neuronal Proliferation and Apoptosis by Adamo, Ana M., Zago, Maria P., Mackenzie, Gerardo G., Aimo, Lucila, Keen, Carl L., Keenan, Alison, Oteiza, Patricia I.

“…Although a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis…”
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A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice by Mackenzie, Gerardo G, Bartels, Lauren E, Xie, Gang, Papayannis, Ioannis, Alston, Ninche, Vrankova, Kvetoslava, Ouyang, Nengtai, Rigas, Basil

“…Pancreatic cancer has one of the poorest prognoses among all cancers partly because of its persistent resistance to chemotherapy. The currently limited…”
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Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice by Guorgui, Jacob, Wang, Ruixue, Mattheolabakis, George, Mackenzie, Gerardo G.

“…Curcumin reduces Hodgkin's lymphoma (HL) cell growth in vitro, but its unfavorable pharmacokinetics highlight the need for novel in vivo delivery systems…”
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Chlorogenic acid combined with epigallocatechin-3-gallate mitigates D-galactose-induced gut aging in mice by Wei, Ran, Su, Zhucheng, Mackenzie, Gerardo G

“…Chlorogenic acid (CGA) and epigallocatechin-3-gallate (EGCG) are major polyphenolic constituents of coffee and green tea with beneficial health properties. In…”
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A high-fat diet induces changes in mesenteric adipose tissue accelerating early-stage pancreatic carcinogenesis in mice by Ead, Aya S., Wirkus, Joanna, Matsukuma, Karen, Mackenzie, Gerardo G.

“…•A high-fat diet accelerates pancreatic carcinogenesis by activating ERK and STAT3.•A high-fat diet promotes immune cell infiltration in the pancreas.•A…”
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Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models by Wei, Ran, Mao, Limin, Xu, Ping, Zheng, Xinghai, Hackman, Robert M, Mackenzie, Gerardo G, Wang, Yuefei

“…Numerous studies propose that epigallocatechin-3-gallate (EGCG), an abundant polyphenol in green tea, has anti-cancer properties. However, its mechanism of…”
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The inhibitory effect of ECG and EGCG dimeric procyanidins on colorectal cancer cells growth is associated with their actions at lipid rafts and the inhibition of the epidermal growth factor receptor signaling by Zhu, Wei, Li, Mei C., Wang, Feng R., Mackenzie, Gerardo G., Oteiza, Patricia I.

“…[Display omitted] Colorectal cancer (CRC) is one of the most common cancers worldwide. Epidemiological studies indicate that consumption of fruits and…”
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Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice by Son, Joshua S, Khair, Shanawaj, Pettet, 3rd, Donald W, Ouyang, Nengtai, Tian, Xinyu, Zhang, Yuanhao, Zhu, Wei, Mackenzie, Gerardo G, Robertson, Charles E, Ir, Diana, Frank, Daniel N, Rigas, Basil, Li, Ellen

“…Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal…”
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Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts by Wei, Ran, Hackman, Robert M., Wang, Yuefei, Mackenzie, Gerardo G.

“…Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of…”
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Pancreatic cancer: A critical review of dietary risk by Salem, Asmaa A., Mackenzie, Gerardo G.

“…Pancreatic cancer is a deadly disease. It is estimated that about 90% of pancreatic cancer cases are due to environmental risk factors. Among these,…”
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