Search Results - "MacKenzie, Alex E."

Rare-disease genetics in the era of next-generation sequencing: discovery to translation by Boycott, Kym M., Vanstone, Megan R., Bulman, Dennis E., MacKenzie, Alex E.

“…Key Points Next-generation sequencing (NGS) and improved sequence analysis methods have markedly increased the rate of identification of genes that cause rare…”
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Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations by D'Aoust, Patrick M., Graber, Tyson E., Mercier, Elisabeth, Montpetit, Danika, Alexandrov, Ilya, Neault, Nafisa, Baig, Aiman Tariq, Mayne, Janice, Zhang, Xu, Alain, Tommy, Servos, Mark R., Srikanthan, Nivetha, MacKenzie, Malcolm, Figeys, Daniel, Manuel, Douglas, Jüni, Peter, MacKenzie, Alex E., Delatolla, Robert

“…Curtailing the Spring 2020 COVID-19 surge required sweeping and stringent interventions by governments across the world. Wastewater-based COVID-19 epidemiology…”
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Municipal and neighbourhood level wastewater surveillance and subtyping of an influenza virus outbreak by Mercier, Elisabeth, D’Aoust, Patrick M., Thakali, Ocean, Hegazy, Nada, Jia, Jian-Jun, Zhang, Zhihao, Eid, Walaa, Plaza-Diaz, Julio, Kabir, Md Pervez, Fang, Wanting, Cowan, Aaron, Stephenson, Sean E., Pisharody, Lakshmi, MacKenzie, Alex E., Graber, Tyson E., Wan, Shen, Delatolla, Robert

“…Recurrent influenza epidemics and pandemic potential are significant risks to global health. Public health authorities use clinical surveillance to locate and…”
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Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model by Neault, Nafisa, Ravel-Chapuis, Aymeric, Baird, Stephen D, Lunde, John A, Poirier, Mathieu, Staykov, Emiliyan, Plaza-Diaz, Julio, Medina, Gerardo, Abadía-Molina, Francisco, Jasmin, Bernard J, MacKenzie, Alex E

“…Myotonic dystrophy type 1 (DM1), the most common form of adult muscular dystrophy, is caused by an abnormal expansion of CTG repeats in the 3' untranslated…”
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Rapidly developed, optimized, and applied wastewater surveillance system for real-time monitoring of low-incidence, high-impact MPOX outbreak by Wong, Chandler H., Zhang, Zhihao, Eid, Walaa, Plaza-Diaz, Julio, Kabir, Pervez, Wan, Shen, Jia, Jian-Jun, Mercier, Elisabeth, Thakali, Ocean, Pisharody, Lakshmi, Hegazy, Nada, Stephenson, Sean E., Fang, Wanting, Nguyen, Tram B., Ramsay, Nathan T., McKay, R. Michael, Corchis-Scott, Ryland, MacKenzie, Alex E., Graber, Tyson E., D’ Aoust, Patrick M., Delatolla, Robert

“…Abstract Recent MPOX viral resurgences have mobilized public health agencies around the world. Recognizing the significant risk of MPOX outbreaks, large-scale…”
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Wastewater-based surveillance identifies start to the pediatric respiratory syncytial virus season in two cities in Ontario, Canada by Mercier, Elisabeth, Pisharody, Lakshmi, Guy, Fiona, Wan, Shen, Hegazy, Nada, D'Aoust, Patrick M, Kabir, Md Pervez, Nguyen, Tram Bich, Eid, Walaa, Harvey, Bart, Rodenburg, Erin, Rutherford, Candy, Mackenzie, Alex E, Willmore, Jacqueline, Hui, Charles, Paes, Bosco, Delatolla, Robert, Thampi, Nisha

“…Detection of community respiratory syncytial virus (RSV) infections informs the timing of immunoprophylaxis programs and hospital preparedness for surging…”
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Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder by Plaza-Diaz, Julio, Radar, Ana Mei, Baig, Aiman Tariq, Leyba, Marcos Federico, Costabel, Maria Macarena, Zavala-Crichton, Juan Pablo, Sanchez-Martinez, Javier, MacKenzie, Alex E, Solis-Urra, Patricio

“…It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut…”
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Corrigendum: Wastewater-based surveillance identifies start to the pediatric respiratory syncytial virus season in two cities in Ontario, Canada by Mercier, Elisabeth, Pisharody, Lakshmi, Guy, Fiona, Wan, Shen, Hegazy, Nada, D'Aoust, Patrick M, Kabir, Md Pervez, Nguyen, Tram Bich, Eid, Walaa, Harvey, Bart, Rodenburg, Erin, Rutherford, Candy, Mackenzie, Alex E, Willmore, Jacqueline, Hui, Charles, Paes, Bosco, Delatolla, Robert, Thampi, Nisha

“…[This corrects the article DOI: 10.3389/fpubh.2023.1261165.]…”
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Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence by D'Aoust, Patrick M., Mercier, Elisabeth, Montpetit, Danika, Jia, Jian-Jun, Alexandrov, Ilya, Neault, Nafisa, Baig, Aiman Tariq, Mayne, Janice, Zhang, Xu, Alain, Tommy, Langlois, Marc-André, Servos, Mark R., MacKenzie, Malcolm, Figeys, Daniel, MacKenzie, Alex E., Graber, Tyson E., Delatolla, Robert

“…•RT-ddPCR is more sensitive to inhibitors than RT-qPCR for primary clarified sludge.•Primary clarified sludge has elevated frequency of SARS-CoV-2 RNA…”
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A generalizable pre-clinical research approach for orphan disease therapy by Beaulieu, Chandree L, Samuels, Mark E, Ekins, Sean, McMaster, Christopher R, Edwards, Aled M, Krainer, Adrian R, Hicks, Geoffrey G, Frey, Brendan J, Boycott, Kym M, Mackenzie, Alex E

“…With the advent of next-generation DNA sequencing, the pace of inherited orphan disease gene identification has increased dramatically, a situation that will…”
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Quantitation of phosphatidylethanols in dried blood spots to determine rates of prenatal alcohol exposure in Ontario by DiBattista, Alicia, Ogrel, Svetlana, MacKenzie, Alex E., Chakraborty, Pranesh

“…Background Estimating rates of prenatal alcohol exposure (PAE) in a population is necessary to ensure that proper medical and social supports and interventions…”
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COVID-19 wastewater surveillance in rural communities: Comparison of lagoon and pumping station samples by D'Aoust, Patrick M., Towhid, Syeda Tasneem, Mercier, Élisabeth, Hegazy, Nada, Tian, Xin, Bhatnagar, Kamya, Zhang, Zhihao, Naughton, Colleen C., MacKenzie, Alex E., Graber, Tyson E., Delatolla, Robert

“…Wastewater-based epidemiology/wastewater surveillance has been a topic of significant interest over the last year due to its application in SARS-CoV-2…”
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The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7 by Maier, Johannes K. X, Lahoua, Zahia, Gendron, Nathalie H, Fetni, Raouf, Johnston, Anne, Davoodi, Jamshid, Rasper, Dita, Roy, Sophie, Slack, Ruth S, Nicholson, Donald W, MacKenzie, Alex E

“…The neuronal apoptosis inhibitory protein (NAIP) was identified as a candidate gene for the inherited neurodegenerative disorder spinal muscular atrophy. NAIP…”
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Understanding the dynamic relation between wastewater SARS-CoV-2 signal and clinical metrics throughout the pandemic by Hegazy, Nada, Cowan, Aaron, D'Aoust, Patrick M., Mercier, Élisabeth, Towhid, Syeda Tasneem, Jia, Jian-Jun, Wan, Shen, Zhang, Zhihao, Kabir, Md Pervez, Fang, Wanting, Graber, Tyson E., MacKenzie, Alex E., Guilherme, Stéphanie, Delatolla, Robert

“…Wastewater surveillance (WWS) of SARS-CoV-2 was proven to be a reliable and complementary tool for population-wide monitoring of COVID-19 disease incidence but…”
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Effective method to mitigate impact of rain or snowmelt sewer flushing events on wastewater-based surveillance measurements by Mercier, Elisabeth, D'Aoust, Patrick M., Renouf, Elizabeth, Tomalty, Emma, Addo, Felix G., Nguyen, Tram Bich, Wong, Chandler H., Ramsay, Nathan T., Tian, Xin, Hegazy, Nada, Kabir, Md Pervez, Jia, Jian-Jun, Wan, Shen, Pisharody, Lakshmi, Szulc, Pawel, MacKenzie, Alex E., Delatolla, Robert

“…Wastewater-based surveillance (WBS) is increasingly used for monitoring disease targets in wastewaters around the world. This study, performed in Ottawa,…”
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Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communities by D'Aoust, Patrick M., Tian, Xin, Towhid, Syeda Tasneem, Xiao, Amy, Mercier, Elisabeth, Hegazy, Nada, Jia, Jian-Jun, Wan, Shen, Kabir, Md Pervez, Fang, Wanting, Fuzzen, Meghan, Hasing, Maria, Yang, Minqing Ivy, Sun, Jianxian, Plaza-Diaz, Julio, Zhang, Zhihao, Cowan, Aaron, Eid, Walaa, Stephenson, Sean, Servos, Mark R., Wade, Matthew J., MacKenzie, Alex E., Peng, Hui, Edwards, Elizabeth A., Pang, Xiao-Li, Alm, Eric J., Graber, Tyson E., Delatolla, Robert

“…Clinical testing has been the cornerstone of public health monitoring and infection control efforts in communities throughout the COVID-19 pandemic. With the…”
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Sewer transport conditions and their role in the decay of endogenous SARS-CoV-2 and pepper mild mottle virus from source to collection by Mercier, Élisabeth, D'Aoust, Patrick M., Eid, Walaa, Hegazy, Nada, Kabir, Pervez, Wan, Shen, Pisharody, Lakshmi, Renouf, Elizabeth, Stephenson, Sean, Graber, Tyson E., MacKenzie, Alex E., Delatolla, Robert

“…This study presents a comprehensive analysis of the decay patterns of endogenous SARS-CoV-2 and Pepper mild mottle virus (PMMoV) within wastewaters spiked with…”
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Distribution of Neuronal Apoptosis Inhibitory Protein in Human Tissues by Maier, Johannes K.X, Balabanian, Sylvia, Coffill, Cynthia R, Stewart, Alexandra, Pelletier, Louise, Franks, Douglas J, Gendron, Nathalie H, MacKenzie, Alex E

“…The neuronal apoptosis inhibitory protein (NAIP) gene, also known as the baculovirus inhibitor of apoptosis repeat-containing protein 1 (BIRC1) gene, is a…”
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Impact of coagulation on SARS-CoV-2 and PMMoV viral signal in wastewater solids by Hegazy, Nada, Tian, Xin, D’Aoust, Patrick M., Pisharody, Lakshmi, Towhid, Syeda Tasneem, Mercier, Élisabeth, Zhang, Zhihao, Wan, Shen, Thakali, Ocean, Kabir, Md Pervez, Fang, Wanting, Nguyen, Tram B., Ramsay, Nathan T., MacKenzie, Alex E., Graber, Tyson E., Guilherme, Stéphanie, Delatolla, Robert

“…Wastewater surveillance (WWS) of SARS-CoV-2 has become a crucial tool for monitoring COVID-19 cases and outbreaks. Previous studies have indicated that…”
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Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome by Dyment, David A, Schock, Sarah C, Deloughery, Kristen, Tran, Minh Hieu, Ure, Kerstin, Nutter, Lauryl M J, Creighton, Amie, Yuan, Julie, Banderali, Umberto, Comas, Tanya, Baumann, Ewa, Jezierski, Anna, Boycott, Kym M, Mackenzie, Alex E, Martina, Marzia

“…Abstract Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A. To characterize the pathogenic substitution…”
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